| The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease E Rogaeva, Y Meng, JH Lee, Y Gu, T Kawarai, F Zou, T Katayama, ... Nature genetics 39 (2), 168-177, 2007 | 1401 | 2007 |
| Presenilin-dependent transcriptional control of the Aβ-degrading enzyme neprilysin by intracellular domains of βAPP and APLP R Pardossi-Piquard, A Petit, T Kawarai, C Sunyach, CA Da Costa, ... Neuron 46 (4), 541-554, 2005 | 424 | 2005 |
| TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity F Chen, H Hasegawa, G Schmitt-Ulms, T Kawarai, C Bohm, T Katayama, ... Nature 440 (7088), 1208-1212, 2006 | 400 | 2006 |
| Presenilin-dependent γ-secretase-mediated control of p53-associated cell death in Alzheimer's disease CA da Costa, C Sunyach, R Pardossi-Piquard, J Sévalle, B Vincent, ... Journal of Neuroscience 26 (23), 6377-6385, 2006 | 220 | 2006 |
| The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus I Lauritzen, R Pardossi-Piquard, C Bauer, E Brigham, JD Abraham, ... Journal of Neuroscience 32 (46), 16243-16255, 2012 | 202 | 2012 |
| The physiology of the β‐amyloid precursor protein intracellular domain AICD R Pardossi‐Piquard, F Checler Journal of neurochemistry 120, 109-124, 2012 | 200 | 2012 |
| Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology I Lauritzen, R Pardossi-Piquard, A Bourgeois, S Pagnotta, MG Biferi, ... Acta neuropathologica 132, 257-276, 2016 | 189 | 2016 |
| Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains L Vaillant-Beuchot, A Mary, R Pardossi-Piquard, A Bourgeois, I Lauritzen, ... Acta neuropathologica 141, 39-65, 2021 | 138 | 2021 |
| Evidence that the amyloid-β protein precursor intracellular domain, AICD, derives from β-secretase-generated C-terminal fragment B Flammang, R Pardossi-Piquard, J Sevalle, D Debayle, AS Dabert-Gay, ... Journal of Alzheimer's Disease 30 (1), 145-153, 2012 | 90 | 2012 |
| Palmitate is increased in the cerebrospinal fluid of humans with obesity and induces memory impairment in mice via pro-inflammatory TNF-α HM Melo, GSS da Silva, MR Sant’Ana, CVL Teixeira, JR Clarke, ... Cell Reports 30 (7), 2180-2194. e8, 2020 | 89 | 2020 |
| Neprilysin activity and expression are controlled by nicastrin R Pardossi‐Piquard, J Dunys, G Yu, P St. George‐Hyslop, ... Journal of neurochemistry 97 (4), 1052-1056, 2006 | 59 | 2006 |
| β-Amyloid precursor protein intracellular domain controls mitochondrial function by modulating phosphatase and tensin homolog–induced kinase 1 transcription in cells and in … T Goiran, E Duplan, M Chami, A Bourgeois, W El Manaa, L Rouland, ... Biological psychiatry 83 (5), 416-427, 2018 | 52 | 2018 |
| APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes R Pardossi-Piquard, SP Yang, S Kanemoto, Y Gu, F Chen, C Böhm, ... Journal of biological chemistry 284 (24), 16298-16307, 2009 | 50 | 2009 |
| γ-Secretase-mediated regulation of neprilysin: influence of cell density and aging and modulation by imatinib C Bauer, R Pardossi-Piquard, J Dunys, M Roy, F Checler Journal of Alzheimer's Disease 27 (3), 511-520, 2011 | 48 | 2011 |
| The γ/η-secretase-derived APP intracellular domain fragments regulate p53 F Checler, C Sunyach, R Pardossi-Piquard, J Sevalle, B Vincent, ... Current Alzheimer Research 4 (4), 423-426, 2007 | 47 | 2007 |
| Does intraneuronal accumulation of carboxyl-terminal fragments of the amyloid precursor protein trigger early neurotoxicity in Alzheimer’s disease? I Lauritzen, R Pardossi-Piquard, A Bourgeois, A Bécot, F Checler Current Alzheimer Research 16 (5), 453-457, 2019 | 46 | 2019 |
| Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3× TgAD and 2× TgAD mice A Bourgeois, I Lauritzen, T Lorivel, C Bauer, F Checler, ... Neurobiology of aging 71, 21-31, 2018 | 46 | 2018 |
| TMP21 transmembrane domain regulates γ-secretase cleavage R Pardossi-Piquard, C Böhm, F Chen, S Kanemoto, F Checler, ... Journal of biological chemistry 284 (42), 28634-28641, 2009 | 43 | 2009 |
| p53 is regulated by and regulates members of the γ-secretase complex F Checler, J Dunys, R Pardossi-Piquard, C Alves da Costa Neurodegenerative Diseases 7 (1-3), 50-55, 2010 | 41 | 2010 |
| Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99? F Checler, E Afram, R Pardossi-Piquard, I Lauritzen Journal of Biological Chemistry 296, 2021 | 40 | 2021 |
Frederic CheclerIPMC, UMR7275 CNRS-UNSVerified email at ipmc.cnrs.fr
