BRAF mutants evade ERK-dependent feedback by different mechanisms that determine their sensitivity to pharmacologic inhibition Z Yao, NM Torres, A Tao, Y Gao, L Luo, Q Li, E de Stanchina, ... Cancer cell 28 (3), 370-383, 2015 | 468 | 2015 |
Diverse and targetable kinase alterations drive histiocytic neoplasms EL Diamond, BH Durham, J Haroche, Z Yao, J Ma, SA Parikh, Z Wang, ... Cancer discovery 6 (2), 154-165, 2016 | 449 | 2016 |
VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex W Zhang, Y Gao, P Li, Z Shi, T Guo, F Li, X Han, Y Feng, C Zheng, ... Cell research 24 (3), 331-343, 2014 | 314 | 2014 |
MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene R Fang, T Xiao, Z Fang, Y Sun, F Li, Y Gao, Y Feng, L Li, Y Wang, X Liu, ... Journal of Biological Chemistry 287 (27), 23227-23235, 2012 | 292 | 2012 |
LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling Y Gao, Q Xiao, HM Ma, L Li, J Liu, Y Feng, Z Fang, J Wu, X Han, J Zhang, ... Proceedings of the National Academy of Sciences 107 (44), 18892-18897, 2010 | 209 | 2010 |
RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling Z Yao, Y Gao, W Su, R Yaeger, J Tao, N Na, Y Zhang, C Zhang, A Rymar, ... Nature medicine 25 (2), 284-291, 2019 | 157 | 2019 |
Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma X Han, F Li, Z Fang, Y Gao, F Li, R Fang, S Yao, Y Sun, L Li, W Zhang, ... Nature communications 5 (1), 1-13, 2014 | 157 | 2014 |
LKB1 inactivation elicits a redox imbalance to modulate non-small cell lung cancer plasticity and therapeutic response F Li, X Han, F Li, R Wang, H Wang, Y Gao, X Wang, Z Fang, W Zhang, ... Cancer cell 27 (5), 698-711, 2015 | 141 | 2015 |
Allele-specific mechanisms of activation of MEK1 mutants determine their properties Y Gao, MT Chang, D McKay, N Na, B Zhou, R Yaeger, NM Torres, ... Cancer discovery 8 (5), 648-661, 2018 | 117 | 2018 |
YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression Y Gao, W Zhang, X Han, F Li, X Wang, R Wang, Z Fang, X Tong, S Yao, ... Nature communications 5 (1), 1-15, 2014 | 114 | 2014 |
Mutant-selective degradation by BRAF-targeting PROTACs S Alabi, S Jaime-Figueroa, Z Yao, Y Gao, J Hines, KTG Samarasinghe, ... Nature communications 12 (1), 1-11, 2021 | 92 | 2021 |
YAP promotes malignant progression of Lkb1-deficient lung adenocarcinoma through downstream regulation of survivin W Zhang, Y Gao, F Li, X Tong, Y Ren, X Han, S Yao, F Long, Z Yang, ... Cancer research 75 (21), 4450-4457, 2015 | 88 | 2015 |
YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63–GPX2 Axis and ROS Accumulation H Huang, W Zhang, Y Pan, Y Gao, L Deng, F Li, F Li, X Ma, S Hou, J Xu, ... Cancer research 77 (21), 5769-5781, 2017 | 82 | 2017 |
Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector J Xu, PX Li, J Wu, YJ Gao, MX Yin, Y Lin, M Yang, DP Chen, HP Sun, ... Clinical Science 130 (5), 349-363, 2016 | 73 | 2016 |
LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor Y Gao, G Ge, H Ji Protein & cell 2 (2), 99-107, 2011 | 59 | 2011 |
The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss Y Feng, Y Wang, Z Wang, Z Fang, F Li, Y Gao, H Liu, T Xiao, F Li, Y Zhou, ... Cancer research 72 (24), 6502-6511, 2012 | 52 | 2012 |
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Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer R Yaeger, R Mezzadra, J Sinopoli, Y Bian, M Marasco, E Kaplun, Y Gao, ... Cancer discovery 13 (1), 41-55, 2023 | 34 | 2023 |
V211D mutation in MEK1 causes resistance to MEK inhibitors in colon cancer Y Gao, A Maria, N Na, A da Cruz Paula, AN Gorelick, JF Hechtman, ... Cancer discovery 9 (9), 1182-1191, 2019 | 34 | 2019 |
Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK mutants in cancer AJ Hanrahan, BE Sylvester, MT Chang, A Elzein, J Gao, W Han, Y Liu, ... Cancer Research 80 (19), 4233-4243, 2020 | 30 | 2020 |