| The role of kinetic context in apparent biased agonism at GPCRs C Klein Herenbrink, DA Sykes, P Donthamsetti, M Canals, T Coudrat, ... Nature communications 7 (1), 10842, 2016 | 320 | 2016 |
| Molecular determinants of selectivity and efficacy at the dopamine D3 receptor AH Newman, T Beuming, AK Banala, P Donthamsetti, K Pongetti, ... Journal of medicinal chemistry 55 (15), 6689-6699, 2012 | 186 | 2012 |
| A new mechanism of allostery in a G protein–coupled receptor dimer JR Lane, P Donthamsetti, J Shonberg, CJ Draper-Joyce, S Dentry, ... Nature chemical biology 10 (9), 745-752, 2014 | 125 | 2014 |
| What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands? M Michino, T Beuming, P Donthamsetti, AH Newman, JA Javitch, L Shi Pharmacological Reviews 67 (1), 198-213, 2015 | 120 | 2015 |
| Optical control of dopamine receptors using a photoswitchable tethered inverse agonist PC Donthamsetti, N Winter, M Schönberger, J Levitz, C Stanley, ... Journal of the American Chemical Society 139 (51), 18522-18535, 2017 | 75 | 2017 |
| Optical control of sphingosine-1-phosphate formation and function J Morstein, RZ Hill, AJE Novak, S Feng, DD Norman, PC Donthamsetti, ... Nature chemical biology 15 (6), 623-631, 2019 | 73 | 2019 |
| New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion ZJ Farino, TJ Morgenstern, A Maffei, M Quick, AJ De Solis, ... Molecular psychiatry 25 (9), 2070-2085, 2020 | 70 | 2020 |
| Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens PF Marcott, S Gong, P Donthamsetti, SG Grinnell, MN Nelson, ... Neuron 98 (3), 575-587. e4, 2018 | 64 | 2018 |
| A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors M Michino, P Donthamsetti, T Beuming, A Banala, L Duan, T Roux, Y Han, ... Molecular pharmacology 84 (6), 854-864, 2013 | 64 | 2013 |
| Using Bioluminescence Resonance Energy Transfer (BRET) to characterize agonist‐induced arrestin recruitment to modified and unmodified G protein‐coupled receptors P Donthamsetti, JR Quejada, JA Javitch, VV Gurevich, NA Lambert Current protocols in pharmacology 70 (1), 2.14. 1-2.14. 14, 2015 | 61 | 2015 |
| Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation P Donthamsetti, EF Gallo, DC Buck, EL Stahl, Y Zhu, JR Lane, LM Bohn, ... Molecular psychiatry 25 (9), 2086-2100, 2020 | 59 | 2020 |
| Genetically targeted optical control of an endogenous G protein-coupled receptor PC Donthamsetti, J Broichhagen, V Vyklicky, C Stanley, Z Fu, M Visel, ... Journal of the American Chemical Society 141 (29), 11522-11530, 2019 | 59 | 2019 |
| High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice CA Boateng, OM Bakare, J Zhan, AK Banala, C Burzynski, E Pommier, ... Journal of medicinal chemistry 58 (15), 6195-6213, 2015 | 57 | 2015 |
| Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor M Michino, CA Boateng, P Donthamsetti, H Yano, OM Bakare, A Bonifazi, ... Journal of medicinal chemistry 60 (2), 580-593, 2017 | 53 | 2017 |
| Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor CC Clayton, P Donthamsetti, NA Lambert, JA Javitch, KA Neve Journal of Biological Chemistry 289 (48), 33663-33675, 2014 | 46 | 2014 |
| Optical control of lysophosphatidic acid signaling J Morstein, MA Dacheux, DD Norman, A Shemet, PC Donthamsetti, ... Journal of the American Chemical Society 142 (24), 10612-10616, 2020 | 37 | 2020 |
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor … MF Zou, TM Keck, V Kumar, P Donthamsetti, M Michino, C Burzynski, ... Journal of medicinal chemistry 59 (7), 2973-2988, 2016 | 36 | 2016 |
| Selective photoswitchable allosteric agonist of a G protein-coupled receptor P Donthamsetti, DB Konrad, B Hetzler, Z Fu, D Trauner, EY Isacoff Journal of the American Chemical Society 143 (24), 8951-8956, 2021 | 32 | 2021 |
| Development of a rapid insulin assay by homogenous time-resolved fluorescence ZJ Farino, TJ Morgenstern, J Vallaghe, N Gregor, P Donthamsetti, ... PLoS One 11 (2), e0148684, 2016 | 31 | 2016 |
| Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors P Donthamsetti, N Winter, A Hoagland, C Stanley, M Visel, S Lammel, ... Nature communications 12 (1), 4775, 2021 | 21 | 2021 |
