| Natural products in drug discovery: advances and opportunities AG Atanasov, SB Zotchev, VM Dirsch, CT Supuran Nature reviews Drug discovery 20 (3), 200-216, 2021 | 2569 | 2021 |
| Production of reactive oxygen species, alteration of cytosolic ascorbate peroxidase, and impairment of mitochondrial metabolism are early events in heat shock-induced … RA Vacca, MC de Pinto, D Valenti, S Passarella, E Marra, L De Gara Plant physiology 134 (3), 1100-1112, 2004 | 460 | 2004 |
| Cytochrome c Is Released in a Reactive Oxygen Species-Dependent Manner and Is Degraded via Caspase-Like Proteases in Tobacco Bright-Yellow 2 Cells en … RA Vacca, D Valenti, A Bobba, RS Merafina, S Passarella, E Marra Plant physiology 141 (1), 208-219, 2006 | 229 | 2006 |
| Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: an overview of Down syndrome, autism, Fragile X and Rett syndrome D Valenti, L de Bari, B De Filippis, A Henrion-Caude, RA Vacca Neuroscience & Biobehavioral Reviews 46, 202-217, 2014 | 199 | 2014 |
| Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention D Tewari, SF Nabavi, SM Nabavi, A Sureda, AA Farooqi, AG Atanasov, ... Pharmacological Research 128, 366-375, 2018 | 182 | 2018 |
| Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome D Valenti, D De Rasmo, A Signorile, L Rossi, L de Bari, I Scala, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (4), 542-552, 2013 | 152 | 2013 |
| Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of cAMP/PKA … D Valenti, GA Manente, L Moro, E Marra, RA Vacca Portland Press Limited, 2011 | 150 | 2011 |
| The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model D Valenti, L de Bari, D de Rasmo, A Signorile, A Henrion-Caude, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1862 (6 …, 2016 | 129 | 2016 |
| Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols M Ajami, H Pazoki-Toroudi, H Amani, SF Nabavi, N Braidy, RA Vacca, ... Neuroscience & Biobehavioral Reviews 73, 39-47, 2017 | 106 | 2017 |
| Role of nitric oxide in neurodegeneration: function, regulation, and inhibition D Tewari, AN Sah, S Bawari, SF Nabavi, AR Dehpour, S Shirooie, ... Current neuropharmacology 19 (2), 114-126, 2021 | 93 | 2021 |
| Mitochondria as pharmacological targets in Down syndrome D Valenti, N Braidy, D De Rasmo, A Signorile, L Rossi, AG Atanasov, ... Free Radical Biology and Medicine 114, 69-83, 2018 | 92 | 2018 |
| Impairment of ATPase, adenine nucleotide translocator, and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy D Valenti, A Tullo, MF Caratozzolo, RS Merafina, P Scartezzini, E Marra, ... Portland Press Limited, 2010 | 92 | 2010 |
| Down syndrome: Neurobiological alterations and therapeutic targets RA Vacca, S Bawari, D Valenti, D Tewari, SF Nabavi, S Shirooie, AN Sah, ... Neuroscience & Biobehavioral Reviews 98, 234-255, 2019 | 87 | 2019 |
| Mitochondrial free radical overproduction due to respiratory chain impairment in the brain of a mouse model of Rett syndrome: protective effect of CNF1 B De Filippis, D Valenti, L de Bari, D De Rasmo, M Musto, A Fabbri, ... Free Radical Biology and Medicine 83, 167-177, 2015 | 80 | 2015 |
| Helium‐Neon laser irradiation of hepatocytes can trigger increase of the mitochondrial membrane potential and can stimulate c‐fos expression in a Ca2+‐dependent manner M Greco, RA Vacca, L Moro, E Perlino, VA Petragallo, E Marra, ... Lasers in Surgery and Medicine: The Official Journal of the American Society …, 2001 | 78 | 2001 |
| Plant polyphenols as natural drugs for the management of Down syndrome and related disorders RA Vacca, D Valenti, S Caccamese, M Daglia, N Braidy, SM Nabavi Neuroscience & Biobehavioral Reviews 71, 865-877, 2016 | 77 | 2016 |
| Negative modulation of mitochondrial oxidative phosphorylation by epigallocatechin-3 gallate leads to growth arrest and apoptosis in human malignant pleural mesothelioma cells D Valenti, L De Bari, GA Manente, L Rossi, L Mutti, L Moro, RA Vacca Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (12 …, 2013 | 71 | 2013 |
| Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration SF Nabavi, A Sureda, AR Dehpour, S Shirooie, AS Silva, KP Devi, ... Biotechnology advances 36 (6), 1768-1778, 2018 | 70 | 2018 |
| Mitochondria can cross cell boundaries: An overview of the biological relevance, pathophysiological implications and therapeutic perspectives of intercellular mitochondrial … D Valenti, RA Vacca, L Moro, A Atlante International journal of molecular sciences 22 (15), 8312, 2021 | 69 | 2021 |
| Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism M Caracausi, V Ghini, C Locatelli, M Mericio, A Piovesan, F Antonaros, ... Scientific reports 8 (1), 2977, 2018 | 67 | 2018 |
