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Dennis SelkoeCo-Director, Ann Romney Center for Neurologic Disases, Brigham and Women's HospitalVerifierad e-postadress på bwh.harvard.edu
Ulf DettmerHarvard Medical School/Brigham and Women's HospitalVerifierad e-postadress på harvard.edu
Eric LuthSimmons UniversityVerifierad e-postadress på simmons.edu
Michael F. BrownProfessor of Chemistry, Physics, & Applied Mathematics, University of ArizonaVerifierad e-postadress på u.arizona.edu
Victoria von SauckenWeill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD ProgramVerifierad e-postadress på med.cornell.edu
Frits KampLudwig Maximilian University MunichVerifierad e-postadress på mail03.med.uni-muenchen.de
Matteo RovereUniversity of Turin, Department of Medical SciencesVerifierad e-postadress på edu.unito.it
Soyon HongVerifierad e-postadress på post.harvard.edu
Ming JinAnn Romney Center for Neurologic Diseases, BWH, HMSVerifierad e-postadress på partners.org
Avigdor LeftinStony Brook University School of MedicineVerifierad e-postadress på stonybrookmedicine.edu
Logan S AhlstromData Scientist, TD Ameritrade (Formerly, postdoc at U. Michigan and Howard Hughes Medical Institute)Verifierad e-postadress på tdameritrade.com
Armin GieseProfessor for Neuropathology, Ludwig-Maximilians-Universität München; CSO MODAG GmbHVerifierad e-postadress på modag.net
Konstanze WinklhoferRuhr University BochumVerifierad e-postadress på ruhr-uni-bochum.de
Stefan EimerVerifierad e-postadress på bio.uni-frankfurt.de
Xianjun Dong, PhDAssistant Professor, Harvard Medical School; Director of Genomics and Bioinformatics Hub, BWHVerifierad e-postadress på rics.bwh.harvard.edu
Birgitt SchueleAssociate Professor, Stanford University School of MedicineVerifierad e-postadress på stanford.edu
Peter HeutinkAlectorVerifierad e-postadress på alector.com
Bruce S. KristalJean Mayer USDA Human Nutrition Research Center on Aging at TuftsVerifierad e-postadress på Tufts.edu
Saranna FanningHarvard Medical School and Brigham & Women's HospitalVerifierad e-postadress på bwh.harvard.edu
Scott SaavedraProfessor Emeritus of Chemistry and Biochemistry, University of ArizonaVerifierad e-postadress på arizona.edu

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tim bartels

University College London, Dementia Research Institute

Verifierad e-postadress på ucl.ac.uk - Startsida

Biochemistry Neurodegeneration Protein folding


Titel Sortera efter citat Sortera efter år Sortera efter titel	Citeras av Citeras av	År
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation T Bartels, JG Choi, DJ Selkoe Nature 477 (7362), 107-110, 2011	1453	2011
Inhibition of mitochondrial fusion by α‐synuclein is rescued by PINK1, Parkin and DJ‐1 F Kamp, N Exner, AK Lutz, N Wender, J Hegermann, B Brunner, ... The EMBO journal 29 (20), 3571-3589, 2010	588	2010
β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease S Mittal, K Bjørnevik, DS Im, A Flierl, X Dong, JJ Locascio, KM Abo, ... Science 357 (6354), 891-898, 2017	423	2017
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation U Dettmer, AJ Newman, F Soldner, ES Luth, NC Kim, VE Von Saucken, ... Nature communications 6 (1), 7314, 2015	328	2015
Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction ES Luth, IG Stavrovskaya, T Bartels, BS Kristal, DJ Selkoe Journal of Biological Chemistry 289 (31), 21490-21507, 2014	315	2014
The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding T Bartels, LS Ahlstrom, A Leftin, F Kamp, C Haass, MF Brown, K Beyer Biophysical journal 99 (7), 2116-2124, 2010	305	2010
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells U Dettmer, AJ Newman, ES Luth, T Bartels, D Selkoe Journal of Biological Chemistry 288 (9), 6371-6385, 2013	278	2013
Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases T Bartels, S De Schepper, S Hong Science 370 (6512), 66-69, 2020	260	2020
Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes S Hong, BL Ostaszewski, T Yang, TT O’Malley, M Jin, K Yanagisawa, S Li, ... Neuron 82 (2), 308-319, 2014	232	2014
N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation T Bartels, NC Kim, ES Luth, DJ Selkoe PloS one 9 (7), e103727, 2014	191	2014
KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity U Dettmer, AJ Newman, VE von Saucken, T Bartels, D Selkoe Proceedings of the National Academy of Sciences 112 (31), 9596-9601, 2015	177	2015
Raftlike Mixtures of Sphingomyelin and Cholesterol Investigated by Solid-State ²H NMR Spectroscopy T Bartels, RS Lankalapalli, R Bittman, K Beyer, MF Brown Journal of the American Chemical Society 130 (44), 14521-14532, 2008	133	2008
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons J Schapansky, S Khasnavis, MP DeAndrade, JD Nardozzi, SR Falkson, ... Neurobiology of disease 111, 26-35, 2018	131	2018
New insights into cellular α-synuclein homeostasis in health and disease U Dettmer, D Selkoe, T Bartels Current opinion in neurobiology 36, 15-22, 2016	101	2016
Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity ES Luth, T Bartels, U Dettmer, NC Kim, DJ Selkoe Biochemistry 54 (2), 279-292, 2015	93	2015
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells U Dettmer, N Ramalingam, VE von Saucken, TE Kim, AJ Newman, ... Human Molecular Genetics 26 (18), 3466-3481, 2017	82	2017
Defining the native state of α-synuclein D Selkoe, U Dettmer, E Luth, N Kim, A Newman, T Bartels Neurodegenerative Diseases 13 (2-3), 114-117, 2014	56	2014
Refolding of helical soluble α‐synuclein through transient interaction with lipid interfaces M Rovere, JB Sanderson, L Fonseca‐Ornelas, DS Patel, T Bartels FEBS letters 592 (9), 1464-1472, 2018	45	2018
E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity M Rovere, AE Powers, H Jiang, JC Pitino, L Fonseca-Ornelas, DS Patel, ... Journal of Biological Chemistry 294 (25), 9799-9812, 2019	40	2019
Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies JB Sanderson, S De, H Jiang, M Rovere, M Jin, L Zaccagnini, ... Brain communications 2 (1), fcaa010, 2020	24	2020

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