Caroline L. Benn
Caroline L. Benn
LoQus23 Therapeutics
Verifierad e-postadress på ddfdiscovery.com
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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
M Björkqvist, EJ Wild, J Thiele, A Silvestroni, R Andre, N Lahiri, ...
The Journal of experimental medicine 205 (8), 1869-1877, 2008
Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner
CL Benn, T Sun, G Sadri-Vakili, KN McFarland, DP DiRocco, GJ Yohrling, ...
Journal of Neuroscience 28 (42), 10720-10733, 2008
Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models
G Sadri-Vakili, B Bouzou, CL Benn, MO Kim, P Chawla, RP Overland, ...
Human molecular genetics 16 (11), 1293-1306, 2007
SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease
M Mielcarek, CL Benn, SA Franklin, DL Smith, B Woodman, PA Marks, ...
PloS one 6 (11), e27746, 2011
Molecular and functional variation in iPSC-derived sensory neurons
J Schwartzentruber, S Foskolou, H Kilpinen, J Rodrigues, K Alasoo, ...
Nature genetics 50 (1), 54-61, 2018
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
D Barsyte-Lovejoy, F Li, MJ Oudhoff, JH Tatlock, A Dong, H Zeng, H Wu, ...
Proceedings of the National Academy of Sciences 111 (35), 12853-12858, 2014
Physiology of hyperuricemia and urate-lowering treatments
CL Benn, P Dua, R Gurrell, P Loudon, A Pike, RI Storer, C Vangjeli
Frontiers in medicine, 160, 2018
Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease
AS Chen-Plotkin, G Sadri-Vakili, GJ Yohrling, MW Braveman, CL Benn, ...
Neurobiology of disease 22 (2), 233-241, 2006
Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease
CL Benn, C Landles, H Li, AD Strand, B Woodman, K Sathasivam, SH Li, ...
Human molecular genetics 14 (20), 3065-3078, 2005
Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective
Z Qiu, F Norflus, B Singh, MK Swindell, R Buzescu, M Bejarano, R Chopra, ...
Journal of Biological Chemistry 281 (24), 16672-16680, 2006
Characterizing human stem cell–derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research
GT Young, A Gutteridge, HDE Fox, AL Wilbrey, L Cao, LT Cho, AR Brown, ...
Molecular Therapy 22 (8), 1530-1543, 2014
Forebrain adenosine A2A receptors contribute to L-3, 4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice
D Xiao, E Bastia, YH Xu, CL Benn, JHJ Cha, TS Peterson, JF Chen, ...
Journal of Neuroscience 26 (52), 13548-13555, 2006
Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease
CL Benn, R Butler, L Mariner, J Nixon, H Moffitt, M Mielcarek, B Woodman, ...
PLoS One 4 (6), e5747, 2009
14 The polyglutamine diseases
GP Bates, C Benn
Huntington's disease, 429, 2002
Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease
CL Benn, H Fox, GP Bates
Molecular neurodegeneration 3 (1), 1-17, 2008
Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington’s disease
CL Benn, EJ Slow, LA Farrell, R Graham, Y Deng, MR Hayden, JHJ Cha
Neuroscience 147 (2), 354-372, 2007
A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development
MS Nahorski, L Al-Gazali, J Hertecant, DJ Owen, GHH Borner, YC Chen, ...
Brain 138 (8), 2147-2160, 2015
Mechanisms of distribution of mouse β-galactosidase in the adult GM1-gangliosidosis brain
MLD Broekman, LA Tierney, C Benn, P Chawla, JH Cha, M Sena-Esteves
Gene therapy 16 (2), 303-308, 2009
Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease
CL Benn, R Luthi-Carter, A Kuhn, G Sadri-Vakili, KL Blankson, SC Dalai, ...
Journal of Neuropathology & Experimental Neurology 69 (8), 817-827, 2010
The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease
JS Bett, CL Benn, KY Ryu, RR Kopito, GP Bates
Journal of cellular and molecular medicine 13 (8b), 2645-2657, 2009
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