Ashley Bush
Ashley Bush
Massachusetts General Hospital, Florey Institute of Neuroscience & Mental Health
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Cited by
Cited by
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
BR Stockwell, JPF Angeli, H Bayir, AI Bush, M Conrad, SJ Dixon, S Fulda, ...
Cell 171 (2), 273-285, 2017
Neurodegenerative diseases and oxidative stress
KJ Barnham, CL Masters, AI Bush
Nature reviews Drug discovery 3 (3), 205-214, 2004
Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
CA McLean, RA Cherny, FW Fraser, SJ Fuller, MJ Smith, K Vbeyreuther, ...
Annals of neurology 46 (6), 860-866, 1999
The neurobiology of zinc in health and disease
CJ Frederickson, JY Koh, AI Bush
Nature Reviews Neuroscience 6 (6), 449-462, 2005
Rapid induction of Alzheimer Aβ amyloid formation by zinc
AI Bush, WH Pettingell, G Multhaup, M d Paradis, JP Vonsattel, JF Gusella, ...
Science 265 (5177), 1464-1467, 1994
Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
RA Cherny, CS Atwood, ME Xilinas, DN Gray, WD Jones, CA McLean, ...
Neuron 30 (3), 665-676, 2001
The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene
RE Tanzi, K Petrukhin, I Chernov, JL Pellequer, W Wasco, B Ross, ...
Nature genetics 5 (4), 344-350, 1993
The metallobiology of Alzheimer's disease
AI Bush
Trends in neurosciences 26 (4), 207-214, 2003
The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
X Huang, CS Atwood, MA Hartshorn, G Multhaup, LE Goldstein, ...
Biochemistry 38 (24), 7609-7616, 1999
Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
F Ng, M Berk, O Dean, AI Bush
International Journal of Neuropsychopharmacology 11 (6), 851-876, 2008
Dramatic aggregation of Alzheimer Aβ by Cu (II) is induced by conditions representing physiological acidosis
CS Atwood, RD Moir, X Huang, RC Scarpa, NME Bacarra, DM Romano, ...
Journal of Biological Chemistry 273 (21), 12817-12826, 1998
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Aβ amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
CW Ritchie, AI Bush, A Mackinnon, S Macfarlane, M Mastwyk, ...
Archives of neurology 60 (12), 1685-1691, 2003
Cu (II) potentiation of Alzheimer Aβ neurotoxicity: correlation with cell-free hydrogen peroxide production and metal reduction
X Huang, MP Cuajungco, CS Atwood, MA Hartshorn, JDA Tyndall, ...
Journal of Biological Chemistry 274 (52), 37111-37116, 1999
Metals and neuroscience
AI Bush
Current opinion in chemical biology 4 (2), 184-191, 2000
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of …
KA Ellis, AI Bush, D Darby, D De Fazio, J Foster, P Hudson, ...
International psychogeriatrics 21 (4), 672-687, 2009
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
L Lannfelt, K Blennow, H Zetterberg, S Batsman, D Ames, J Harrison, ...
The Lancet Neurology 7 (9), 779-786, 2008
Alzheimer's disease amyloid-β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
CC Curtain, F Ali, I Volitakis, RA Cherny, RS Norton, K Beyreuther, ...
Journal of Biological Chemistry 276 (23), 20466-20473, 2001
Zinc in the physiology and pathology of the CNS
SL Sensi, P Paoletti, AI Bush, I Sekler
Nature reviews neuroscience 10 (11), 780-791, 2009
Characterization of copper interactions with Alzheimer amyloid β peptides: identification of an attomolar‐affinity copper binding site on amyloid β1‐42
CS Atwood, RC Scarpa, X Huang, RD Moir, WD Jones, DP Fairlie, ...
Journal of neurochemistry 75 (3), 1219-1233, 2000
Metals in Alzheimer's and Parkinson's diseases
KJ Barnham, AI Bush
Current opinion in chemical biology 12 (2), 222-228, 2008
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