Bret Sellman
Bret Sellman
Director, Discovery Microbiome, AstraZeneca
Verified email at
Cited by
Cited by
Designing a polyvalent inhibitor of anthrax toxin
M Mourez, RS Kane, J Mogridge, S Metallo, P Deschatelets, BR Sellman, ...
Nature biotechnology 19 (10), 958-961, 2001
Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax
BR Sellman, M Mourez, RJ Collier
Science 292 (5517), 695-697, 2001
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa
A DiGiandomenico, AE Keller, C Gao, GJ Rainey, P Warrener, ...
Science Translational Medicine 6 (262), 262ra155-262ra155, 2014
Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia
L Hua, JJ Hilliard, Y Shi, C Tkaczyk, LI Cheng, X Yu, V Datta, S Ren, ...
Antimicrobial agents and chemotherapy 58 (2), 1108-1117, 2014
Differential expression and roles of Staphylococcus aureus virulence determinants during colonization and disease
A Jenkins, BA Diep, TT Mai, NH Vo, P Warrener, J Suzich, CK Stover, ...
MBio 6 (1), 2015
Point mutations in anthrax protective antigen that block translocation
BR Sellman, S Nassi, RJ Collier
Journal of biological chemistry 276 (11), 8371-8376, 2001
Identification of anti-alpha toxin monoclonal antibodies that reduce the severity of Staphylococcus aureus dermonecrosis and exhibit a correlation between affinity and potency
C Tkaczyk, L Hua, R Varkey, Y Shi, L Dettinger, R Woods, A Barnes, ...
Clinical and Vaccine Immunology 19 (3), 377-385, 2012
A novel anti-PcrV antibody providing enhanced protection against Pseudomonas aeruginosa in multiple animal infection models
P Warrener, R Varkey, JC Bonnell, A DiGiandomenico, M Camara, ...
Antimicrobial agents and chemotherapy 58 (8), 4384-4391, 2014
Moving toward endotypes in atopic dermatitis: identification of patient clusters based on serum biomarker analysis
JL Thijs, I Strickland, CAFM Bruijnzeel-Koomen, S Nierkens, ...
Journal of Allergy and Clinical Immunology 140 (3), 730-737, 2017
Generation of a membrane‐bound, oligomerized pre‐pore complex is necessary for pore formation by Clostridium septicum alpha toxin
BR Sellman, BL Kagan, RK Tweten
Molecular microbiology 23 (3), 551-558, 1997
Identification of immunogenic and serum binding proteins of Staphylococcus epidermidis
BR Sellman, AP Howell, C Kelly-Boyd, SM Baker
Infection and immunity 73 (10), 6591-6600, 2005
Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections
TS Cohen, JJ Hilliard, O Jones-Nelson, AE Keller, T O’Day, C Tkaczyk, ...
Science Translational Medicine 8 (329), 329ra31-329ra31, 2016
Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model
C Tkaczyk, MM Hamilton, V Datta, XP Yang, JJ Hilliard, GL Stephens, ...
PLoS One 8 (10), e75103, 2013
2001: a year of major advances in anthrax toxin research
M Mourez, DB Lacy, K Cunningham, R Legmann, BR Sellman, ...
TRENDS in Microbiology 10 (6), 287-293, 2002
Antibacterial monoclonal antibodies: the next generation?
A DiGiandomenico, BR Sellman
Current opinion in microbiology 27, 78-85, 2015
Mechanisms of neutralization of a human anti-α-toxin antibody
V Oganesyan, L Peng, MM Damschroder, L Cheng, A Sadowska, ...
Journal of Biological Chemistry 289 (43), 29874-29880, 2014
Effects of linezolid on suppressing in vivo production of staphylococcal toxins and improving survival outcomes in a rabbit model of methicillin-resistant Staphylococcus aureus …
BA Diep, A Afasizheva, HN Le, O Kajikawa, G Matute-Bello, C Tkaczyk, ...
The Journal of infectious diseases 208 (1), 75-82, 2013
α-Toxin induces platelet aggregation and liver injury during Staphylococcus aureus sepsis
BGJ Surewaard, A Thanabalasuriar, Z Zeng, C Tkaczyk, TS Cohen, ...
Cell host & microbe 24 (2), 271-284. e3, 2018
IVIG-mediated protection against necrotizing pneumonia caused by MRSA
BA Diep, VTM Le, C Badiou, HN Le, MG Pinheiro, AH Duong, X Wang, ...
Science translational medicine 8 (357), 357ra124-357ra124, 2016
Heterogeneous in vivo expression of clumping factor A and capsular polysaccharide by Staphylococcus aureus: implications for vaccine design
JS Nanra, Y Timofeyeva, SM Buitrago, BR Sellman, DA Dilts, P Fink, ...
Vaccine 27 (25-26), 3276-3280, 2009
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