Alex Sigal
Alex Sigal
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Dynamics of the p53-Mdm2 feedback loop in individual cells
G Lahav, N Rosenfeld, A Sigal, N Geva-Zatorsky, AJ Levine, MB Elowitz, ...
Nature genetics 36 (2), 147-150, 2004
Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome
A Sigal, V Rotter
Cancer research 60 (24), 6788-6793, 2000
Oscillations and variability in the p53 system
N Geva‐Zatorsky, N Rosenfeld, S Itzkovitz, R Milo, A Sigal, E Dekel, ...
Molecular systems biology 2 (1), 2006.0033, 2006
Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa
H Tegally, E Wilkinson, M Giovanetti, A Iranzadeh, V Fonseca, ...
MedRxiv, 2020
Dynamic proteomics of individual cancer cells in response to a drug
AA Cohen, N Geva-Zatorsky, E Eden, M Frenkel-Morgenstern, I Issaeva, ...
science 322 (5907), 1511-1516, 2008
Variability and memory of protein levels in human cells
A Sigal, R Milo, A Cohen, N Geva-Zatorsky, Y Klein, Y Liron, N Rosenfeld, ...
Nature 444 (7119), 643-646, 2006
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
A Sigal, JT Kim, AB Balazs, E Dekel, A Mayo, R Milo, D Baltimore
Nature 477 (7362), 95-98, 2011
Efficacy of the ChAdOx1 nCoV-19 Covid-19 vaccine against the B. 1.351 variant
SA Madhi, V Baillie, CL Cutland, M Voysey, AL Koen, L Fairlie, ...
New England Journal of Medicine 384 (20), 1885-1898, 2021
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
WF Garcia-Beltran, EC Lam, KS Denis, AD Nitido, ZH Garcia, BM Hauser, ...
Cell 184 (9), 2372-2383. e9, 2021
Collective and single cell behavior in epithelial contact inhibition
A Puliafito, L Hufnagel, P Neveu, S Streichan, A Sigal, DK Fygenson, ...
Proceedings of the National Academy of Sciences 109 (3), 739-744, 2012
Escape of SARS-CoV-2 501Y. V2 from neutralization by convalescent plasma
S Cele, I Gazy, L Jackson, SH Hwa, H Tegally, G Lustig, J Giandhari, ...
Nature 593 (7857), 142-146, 2021
Detection of a SARS-CoV-2 variant of concern in South Africa
H Tegally, E Wilkinson, M Giovanetti, A Iranzadeh, V Fonseca, ...
Nature 592 (7854), 438-443, 2021
Dynamics and variability of ERK2 response to EGF in individual living cells
C Cohen-Saidon, AA Cohen, A Sigal, Y Liron, U Alon
Molecular cell 36 (5), 885-893, 2009
Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53
A Seluanov, V Gorbunova, A Falcovitz, A Sigal, M Milyavsky, I Zurer, ...
Molecular and cellular biology 21 (5), 1552-1564, 2001
The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment
A Sigal, DA Bleijs, V Grabovsky, SJ van Vliet, O Dwir, CG Figdor, ...
The Journal of Immunology 165 (1), 442-452, 2000
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins
A Sigal, R Milo, A Cohen, N Geva-Zatorsky, Y Klein, I Alaluf, N Swerdlin, ...
Nature methods 3 (7), 525-531, 2006
Sixteen novel lineages of SARS-CoV-2 in South Africa
H Tegally, E Wilkinson, RJ Lessells, J Giandhari, S Pillay, N Msomi, ...
Nature Medicine 27 (3), 440-446, 2021
Integrity of the N‐terminal transcription domain of p53 is required for mutant p53 interference with drug‐induced apoptosis
D Matas, A Sigal, P Stambolsky, M Milyavsky, L Weisz, D Schwartz, ...
The EMBO journal 20 (15), 4163-4172, 2001
Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein.
H Tegally, E Wilkinson, M Giovanetti, A Iranzadeh, V Fonseca, ...
Nature, 2021
Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells
D Mahamed, M Boulle, Y Ganga, C Mc Arthur, S Skroch, L Oom, ...
Elife 6, e22028, 2017
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