| Stochastic differential equations as a tool to regularize the parameter estimation problem for continuous time dynamical systems given discrete time measurements J Leander, T Lundh, M Jirstrand Mathematical Biosciences 251, 54-62, 2014 | 51 | 2014 |
| Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood J Almquist, J Leander, M Jirstrand Journal of pharmacokinetics and pharmacodynamics 42, 191-209, 2015 | 46 | 2015 |
| Mixed effects modeling using stochastic differential equations: illustrated by pharmacokinetic data of nicotinic acid in obese Zucker rats J Leander, J Almquist, C Ahlström, J Gabrielsson, M Jirstrand The AAPS journal 17, 586-596, 2015 | 46 | 2015 |
| Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials TH Myrbäck, S Prothon, K Edman, J Leander, M Hashemi, M Dearman, ... The Lancet Rheumatology 2 (1), e31-e41, 2020 | 17 | 2020 |
| Nonlinear mixed effects modeling of deterministic and stochastic dynamical systems in Wolfram Mathematica J Leander, J Almquist, A Johnning, J Larsson, M Jirstrand IFAC-PapersOnLine 54 (7), 409-414, 2021 | 16 | 2021 |
| Mathematical Modeling of Malaria: Methods for Simulation of Epidemics P Johansson, J Leander | 12* | 2010 |
| Joint feedback analysis modeling of nonesterified fatty acids in obese Zucker rats and normal Sprague–Dawley rats after different routes of administration of nicotinic acid S Tapani, J Almquist, J Leander, C Ahlström, LA Peletier, M Jirstrand, ... Journal of Pharmaceutical Sciences 103 (8), 2571-2584, 2014 | 11 | 2014 |
| Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics HK Olafsdottir, J Leander, J Almquist, M Jirstrand The AAPS journal 20 (5), 88, 2018 | 10 | 2018 |
| A semi-mechanistic exposure–response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated … J Leander, M Sunnåker, D Rekić, S Aksenov, UG Eriksson, S Johansson, ... Journal of Pharmacokinetics and Pharmacodynamics 48, 525-541, 2021 | 9 | 2021 |
| A stochastic mixed effects model to assess treatment effects and fluctuations in home‐measured peak expiratory flow and the association with exacerbation risk in asthma J Leander, M Jirstrand, UG Eriksson, R Palmér CPT: Pharmacometrics & Systems Pharmacology, 2021 | 8 | 2021 |
| Estimation of equipotent doses for anti‐inflammatory effects of prednisolone and AZD9567, an oral selective non‐steroidal glucocorticoid receptor modulator J Almquist, MW Sadiq, UG Eriksson, T Hegelund Myrbäck, S Prothon, ... CPT: Pharmacometrics & Systems Pharmacology 9, 444-455, 2020 | 7 | 2020 |
| Higher Febuxostat Exposure Observed in Asian Compared with Caucasian Subjects Independent of Bodyweight D Rekić, S Johansson, J Leander Clinical Pharmacokinetics 60 (3), 319-328, 2021 | 5 | 2021 |
| NLMEModeling: a wolfram mathematica package for nonlinear mixed effects modeling of dynamical systems J Leander, J Almquist, A Johnning, J Larsson, M Jirstrand arXiv preprint arXiv:2011.06879, 2020 | 4 | 2020 |
| SAT0245 Azd9567: a novel oral selective glucocorticoid receptor modulator, demonstrated to have an improved therapeutic ratio compared to prednisolone in pre-clinical studies … R Hendrickx, T Hegelund-Myrbäck, M Dearman, S Prothon, G Edenro, ... Annals of the Rheumatic Diseases 77 (Suppl 2), 984-985, 2018 | 2 | 2018 |
| P138 Urinary leukotriene E4 (uLTE4) pharmacodynamic biomarker for early decision making in the AZD9898 adaptive phase i study J Betts, B Larsson, A Jauhiainen, T Hegelund-Myrbäck, J Leander, ... Thorax 73 (Suppl 4), A177-A177, 2018 | 1 | 2018 |
| A machine learning approach to population pharmacokinetic modelling automation S Richardson, II Arana, A Nowojewski, D Zhou, J Leander, W Tang, ... | | 2024 |
| A streamlined, semi-automated workflow allows quick and efficient QTc and other ECG intervals modelling assessment, saving time and cost J Parkinson, A Ebrahimi, C Gottfridsson, J Leander, D Rupani, CD Dota, ... Population Approach Group Europe (PAGE), 2024 | | 2024 |
| Simulation-based comparison of MMRM and dose-response MMRM for Ph2b dose-finding design in rheumatoid arthritis J Leander, D Ramsay, E Molins, M Pilling, J Sánchez, S Tapani, ... Population Approach Group Europe (PAGE), 2024 | | 2024 |
| A frailty model for quantifying the association between CompEx risk and variation in lung function L Jakobsson, M Jirstrand, P Gerlee, J Cooper, J Leander Population Approach Group Europe (PAGE), 2024 | | 2024 |
| Stochastic Gate Neural Networks for Automatic Covariate Selection in Pharmacometrics Population Modeling M Kekic, O Stepanov, A Nowojewski, S Richardson, II Arana, J Leander, ... Population Approach Group Europe (PAGE), 2024 | | 2024 |
Mats JirstrandAssociate Professor, Head of Department, Fraunhofer-Chalmers CentreVerifierad e-postadress på fcc.chalmers.se
