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Helena Thörn
Helena Thörn
Pharmaceutical Technology and Development, AstraZeneca
Verifierad e-postadress på astrazeneca.com
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In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models
E Sjögren, H Thorn, C Tannergren
Molecular pharmaceutics 13 (6), 1763-1778, 2016
852016
IMI–Oral biopharmaceutics tools project–Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results
A Margolskee, AS Darwich, X Pepin, L Aarons, A Galetin, ...
European Journal of Pharmaceutical Sciences 96, 610-625, 2017
642017
Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans
HA Thörn, A Lundahl, JA Schrickx, PA Dickinson, H Lennernäs
European journal of pharmaceutical sciences 43 (3), 89-98, 2011
622011
IMI–Oral biopharmaceutics tools project–Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across …
AS Darwich, A Margolskee, X Pepin, L Aarons, A Galetin, ...
European Journal of Pharmaceutical Sciences 96, 626-642, 2017
462017
Pulmonary absorption–estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis
J Eriksson, E Sjögren, H Thörn, K Rubin, P Bäckman, H Lennernäs
European Journal of Pharmaceutics and Biopharmaceutics 124, 1-12, 2018
402018
Ranking in vitro dissolution of inhaled micronized drug powders including a candidate drug with two different particle sizes
F Franek, R Fransson, H Thorn, P Backman, PU Andersson, U Tehler
Molecular pharmaceutics 15 (11), 5319-5326, 2018
292018
Pulmonary dissolution of poorly soluble compounds studied in an ex vivo rat lung model
J Eriksson, H Thörn, E Sjögren, L Holmstén, K Rubin, H Lennernäs
Molecular Pharmaceutics 16 (7), 3053-3064, 2019
262019
IMI–Oral biopharmaceutics tools project–Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling …
A Ahmad, X Pepin, L Aarons, Y Wang, AS Darwich, JM Wood, ...
European Journal of Pharmaceutics and Biopharmaceutics 156, 50-63, 2020
252020
Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of …
HA Thörn, M Hedeland, U Bondesson, L Knutson, M Yasin, P Dickinson, ...
Drug metabolism and disposition 37 (11), 2186-2196, 2009
232009
Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
J Eriksson, E Sjögren, H Lennernäs, H Thörn
The AAPS Journal 22, 1-12, 2020
172020
Pulmonary drug absorption and systemic exposure in human: predictions using physiologically based biopharmaceutics modeling
J Eriksson, H Thörn, H Lennernäs, E Sjögren
European Journal of Pharmaceutics and Biopharmaceutics 156, 191-202, 2020
162020
Extensive intestinal glucuronidation of raloxifene in vivo in pigs and impact for oral drug delivery
HA Thörn, M Yasin, PA Dickinson, H Lennernäs
Xenobiotica 42 (9), 917-928, 2012
142012
Lung-Sim: a physiologically based biopharmaceutical prediction tool
U Tehler, R Fransson, H Thorn, F Franek, J Westergren
Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2018
82018
Binding Processes Determine the Stereoselective Intestinal and Hepatic Extraction of Verapamil in Vivo
HA Thörn, E Sjögren, PA Dickinson, H Lennernäs
Molecular Pharmaceutics 9 (11), 3034-3045, 2012
72012
Reply to “Comment on ‘In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models’”
E Sjögren, H Thörn, C Tannergren
Molecular Pharmaceutics 14 (1), 340-343, 2017
62017
First-pass Intestinal Metabolism of Drugs: Experiences from in vitro, in vivo and simulation studies
HA Thörn
Acta Universitatis Upsaliensis, 2012
32012
Ranking in vitro dissolution of orally inhaled drug substance powders in a time-efficient manner
F Franek, L Nilsson, H Thörn, R Fransson, U Tehler
J. Aerosol Med. Pulm. Drug Delivery 32, A17, 2019
22019
Deposition modelling of inhaled aclidinium and budesonide and comparison to gamma scintigraphy measurement
H Thorn, T Loof, G Petersson, F Franek, R Fransson, U Tehler
Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2018
22018
Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption (vol 22, 71, 2020)
J Eriksson, E Sjogren, H Lennernas, H Thorn
AAPS JOURNAL 23 (1), 2021
12021
Experimental evidence of regional lung deposition differences effecting the systemic exposure in dog
S Oag, H Thorn, U Tehler
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY 33 (2), A27-A27, 2020
12020
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