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Akul Singhania
Akul Singhania
Senior Scientist, Computational Biology at Kronos Bio
Verifierad e-postadress på kronosbio.com
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An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients
CA Spina, J Anderson, NM Archin, A Bosque, J Chan, M Famiglietti, ...
PLoS pathogens 9 (12), e1003834, 2013
4472013
A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection
A Singhania, R Verma, CM Graham, J Lee, T Tran, M Richardson, ...
Nature communications 9 (1), 2308, 2018
1772018
Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Z Jevnikar, J Östling, E Ax, J Calvén, K Thörn, E Israelsson, L Öberg, ...
Journal of allergy and clinical immunology 143 (2), 577-590, 2019
1532019
Multitissue transcriptomics delineates the diversity of airway T cell functions in asthma
A Singhania, JC Wallington, CG Smith, D Horowitz, KJ Staples, ...
American journal of respiratory cell and molecular biology 58 (2), 261-270, 2018
972018
The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis
A Singhania, RJ Wilkinson, M Rodrigue, P Haldar, A O’Garra
Nature immunology 19 (11), 1159-1168, 2018
932018
CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition
D Gallo, JTF Young, J Fourtounis, G Martino, A Álvarez-Quilón, C Bernier, ...
Nature 604 (7907), 749-756, 2022
812022
Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis
L Moreira-Teixeira, O Tabone, CM Graham, A Singhania, E Stavropoulos, ...
Nature immunology 21 (4), 464-476, 2020
752020
Whole Serum 3D LC-nESI-FTMS Quantitative Proteomics Reveals Sexual Dimorphism in the Milieu Intérieur of Overweight and Obese Adults
NM Al-Daghri, OS Al-Attas, HE Johnston, A Singhania, MS Alokail, ...
Journal of proteome research 13 (11), 5094-5105, 2014
732014
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases
A Singhania, CM Graham, L Gabryšová, L Moreira-Teixeira, ...
Nature communications 10 (1), 2887, 2019
642019
Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models
SY Wu, A Singhania, M Burgess, LN Putral, C Kirkpatrick, NM Davies, ...
Gene therapy 18 (1), 14-22, 2011
582011
Altered epithelial gene expression in peripheral airways of severe asthma
A Singhania, H Rupani, N Jayasekera, S Lumb, P Hales, N Gozzard, ...
PloS one 12 (1), e0168680, 2017
562017
Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis
O Tabone, R Verma, A Singhania, P Chakravarty, WJ Branchett, ...
Journal of Experimental Medicine 218 (10), e20210915, 2021
472021
Differential gene expression in HIV-infected individuals following ART
M Massanella, A Singhania, N Beliakova-Bethell, R Pier, SM Lada, ...
Antiviral research 100 (2), 420-428, 2013
452013
Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis
T Sathyamoorthy, G Sandhu, LB Tezera, R Thomas, A Singhania, ...
PloS one 10 (1), e0117605, 2015
422015
Gene expression in human fungal pathogen Coccidioides immitis changes as arthroconidia differentiate into spherules and mature
S Viriyakosol, A Singhania, J Fierer, J Goldberg, TN Kirkland, CH Woelk
BMC microbiology 13, 1-15, 2013
422013
Vitamin D metabolites inhibit hepatitis C virus and modulate cellular gene expression
JA Gutierrez, KA Jones, R Flores, A Singhania, CH Woelk, RT Schooley, ...
Journal of virology & antiviral research 3 (3), 2014
382014
HLA-DR marks recently divided antigen-specific effector CD4 T cells in active tuberculosis patients
R Tippalagama, A Singhania, P Dubelko, CS Lindestam Arlehamn, ...
The Journal of Immunology 207 (2), 523-533, 2021
362021
OnPLS-based multi-block data integration: a multivariate approach to interrogating biological interactions in asthma
SN Reinke, B Galindo-Prieto, T Skotare, DI Broadhurst, A Singhania, ...
Analytical chemistry 90 (22), 13400-13408, 2018
332018
The TCR repertoire of α-synuclein-specific T cells in Parkinson's disease is surprisingly diverse
A Singhania, J Pham, R Dhanwani, A Frazier, JR Dutra, KS Marder, ...
Scientific reports 11 (1), 302, 2021
322021
Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4+ T cells
N Beliakova-Bethell, JX Zhang, A Singhania, V Lee, VH Terry, ...
AIDS 27 (1), 29-37, 2013
312013
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Artiklar 1–20