Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding JF Scheid, H Mouquet, B Ueberheide, R Diskin, F Klein, TYK Oliveira, ... Science 333 (6049), 1633-1637, 2011 | 1369 | 2011 |
Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization F Klein, R Diskin, JF Scheid, C Gaebler, H Mouquet, IS Georgiev, ... Cell 153 (1), 126-138, 2013 | 647 | 2013 |
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice F Klein, A Halper-Stromberg, JA Horwitz, H Gruell, JF Scheid, ... Nature 492 (7427), 118-122, 2012 | 587 | 2012 |
Increasing the potency and breadth of an HIV antibody by using structure-based rational design R Diskin, JF Scheid, PM Marcovecchio, AP West Jr, F Klein, H Gao, ... Science 334 (6060), 1289-1293, 2011 | 439 | 2011 |
Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients C Kreer, M Zehner, T Weber, MS Ercanoglu, L Gieselmann, C Rohde, ... Cell 182 (4), 843-854. e12, 2020 | 379 | 2020 |
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques M Shingai, OK Donau, RJ Plishka, A Buckler-White, JR Mascola, ... Journal of Experimental Medicine 211 (10), 2061-2074, 2014 | 361 | 2014 |
Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120 AP West Jr, R Diskin, MC Nussenzweig, PJ Bjorkman Proceedings of the National Academy of Sciences 109 (30), E2083-E2090, 2012 | 266 | 2012 |
Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs S Hoot, AT McGuire, KW Cohen, RK Strong, L Hangartner, F Klein, ... PLoS pathogens 9 (1), e1003106, 2013 | 232 | 2013 |
Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity R Diskin, PM Marcovecchio, PJ Bjorkman Nature structural & molecular biology 17 (5), 608-613, 2010 | 132 | 2010 |
Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV SA Ehrhardt, M Zehner, V Krähling, H Cohen-Dvashi, C Kreer, N Elad, ... Nature medicine 25 (10), 1589-1600, 2019 | 115 | 2019 |
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces S Warszawski, A Borenstein Katz, R Lipsh, L Khmelnitsky, G Ben Nissan, ... PLoS computational biology 15 (8), e1007207, 2019 | 106 | 2019 |
Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies R Diskin, F Klein, JA Horwitz, A Halper-Stromberg, DN Sather, ... Journal of Experimental Medicine 210 (6), 1235-1249, 2013 | 105 | 2013 |
Assembly mechanism of mucin and von Willebrand factor polymers G Javitt, L Khmelnitsky, L Albert, LS Bigman, N Elad, D Morgenstern, ... Cell 183 (3), 717-729. e16, 2020 | 104 | 2020 |
Molecular mechanism for LAMP1 recognition by Lassa virus H Cohen-Dvashi, N Cohen, H Israeli, R Diskin Journal of virology 89 (15), 7584-7592, 2015 | 96 | 2015 |
A mouse model for HIV-1 entry J Pietzsch, H Gruell, S Bournazos, BM Donovan, F Klein, R Diskin, ... Proceedings of the National Academy of Sciences 109 (39), 15859-15864, 2012 | 90 | 2012 |
Structures of p38α active mutants reveal conformational changes in L16 loop that induce autophosphorylation and activation R Diskin, M Lebendiker, D Engelberg, O Livnah Journal of molecular biology 365 (1), 66-76, 2007 | 89 | 2007 |
Active mutants of the human p38α mitogen-activated protein kinase R Diskin, N Askari, R Capone, D Engelberg, O Livnah Journal of Biological Chemistry 279 (45), 47040-47049, 2004 | 84 | 2004 |
Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody L Scharf, AP West Jr, H Gao, T Lee, JF Scheid, MC Nussenzweig, ... Proceedings of the National Academy of Sciences 110 (15), 6049-6054, 2013 | 81 | 2013 |
Intrinsically active variants of all human p38 isoforms M Avitzour, R Diskin, B Raboy, N Askari, D Engelberg, O Livnah The FEBS journal 274 (4), 963-975, 2007 | 80 | 2007 |
Role of LAMP1 binding and pH sensing by the spike complex of Lassa virus H Cohen-Dvashi, H Israeli, O Shani, A Katz, R Diskin Journal of virology 90 (22), 10329-10338, 2016 | 71 | 2016 |