James Shorter
James Shorter
Professor of Biochemistry and Biophysics, University of Pennsylvania
Verified email at pennmedicine.upenn.edu - Homepage
TitleCited byYear
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
HJ Kim, NC Kim, YD Wang, EA Scarborough, J Moore, Z Diaz, ...
Nature 495 (7442), 467, 2013
Stress granules as crucibles of ALS pathogenesis
YR Li, OD King, J Shorter, AD Gitler
J Cell Biol 201 (3), 361-372, 2013
TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity
BS Johnson, D Snead, JJ Lee, JM McCaffery, J Shorter, AD Gitler
Journal of Biological Chemistry 284 (30), 20329-20339, 2009
Prions as adaptive conduits of memory and inheritance
J Shorter, S Lindquist
Nature Reviews Genetics 6 (6), 435, 2005
A complex of mammalian ufd1 and npl4 links the AAA‐ATPase, p97, to ubiquitin and nuclear transport pathways
HH Meyer, JG Shorter, J Seemann, D Pappin, G Warren
The EMBO journal 19 (10), 2181-2192, 2000
The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis
AD Gitler, BJ Bevis, J Shorter, KE Strathearn, S Hamamichi, LJ Su, ...
Proceedings of the National Academy of Sciences 105 (1), 145-150, 2008
Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers
J Shorter, S Lindquist
Science 304 (5678), 1793-1797, 2004
The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
OD King, AD Gitler, J Shorter
Brain research 1462, 61-80, 2012
Golgi architecture and inheritance
J Shorter, G Warren
Annual review of cell and developmental biology 18 (1), 379-420, 2002
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS
Z Sun, Z Diaz, X Fang, MP Hart, A Chesi, J Shorter, AD Gitler
PLoS biology 9 (4), e1000614, 2011
A yeast functional screen predicts new candidate ALS disease genes
J Couthouis, MP Hart, J Shorter, M DeJesus-Hernandez, R Erion, ...
Proceedings of the National Academy of Sciences 108 (52), 20881-20890, 2011
GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell‐free system
J Shorter, R Watson, ME Giannakou, M Clarke, G Warren, FA Barr
The EMBO journal 18 (18), 4949-4960, 1999
Prion-like disorders: blurring the divide between transmissibility and infectivity
M Cushman, BS Johnson, OD King, AD Gitler, J Shorter
J Cell Sci 123 (8), 1191-1201, 2010
Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115
J Shorter, MB Beard, J Seemann, AB Dirac-Svejstrup, G Warren
The Journal of cell biology 157 (1), 45-62, 2002
Protein phase separation: a new phase in cell biology
S Boeynaems, S Alberti, NL Fawzi, T Mittag, M Polymenidou, F Rousseau, ...
Trends in cell biology 28 (6), 420-435, 2018
The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system
J Shorter
PloS one 6 (10), e26319, 2011
Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis
J Couthouis, MP Hart, R Erion, OD King, Z Diaz, T Nakaya, F Ibrahim, ...
Human molecular genetics 21 (13), 2899-2911, 2012
Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities
J Shorter, S Lindquist
Molecular cell 23 (3), 425-438, 2006
A direct role for GRASP65 as a mitotically regulated Golgi stacking factor
Y Wang, J Seemann, M Pypaert, J Shorter, G Warren
The EMBO journal 22 (13), 3279-3290, 2003
Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions
J Shorter, S Lindquist
The EMBO journal 27 (20), 2712-2724, 2008
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