| Visible‐Light‐Initiated Manganese Catalysis for C− H Alkylation of Heteroarenes: Applications and Mechanistic Studies P Nuhant, MS Oderinde, J Genovino, A Juneau, Y Gagné, C Allais, ... Angewandte Chemie International Edition 56 (48), 15309-15313, 2017 | 170 | 2017 |
| Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent … KL Lee, CM Ambler, DR Anderson, BP Boscoe, AG Bree, JI Brodfuehrer, ... Journal of medicinal chemistry 60 (13), 5521-5542, 2017 | 127 | 2017 |
| Covalent enzyme inhibition through fluorosulfate modification of a noncatalytic serine residue OO Fadeyi, LR Hoth, C Choi, X Feng, A Gopalsamy, EC Hett, RE Kyne Jr, ... ACS Chemical Biology 12 (8), 2015-2020, 2017 | 102 | 2017 |
| Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors JA Pfefferkorn, Y Song, KL Sun, SR Miller, BK Trivedi, C Choi, ... Bioorganic & medicinal chemistry letters 17 (16), 4538-4544, 2007 | 83 | 2007 |
| Designing glucokinase activators with reduced hypoglycemia risk: discovery of N, N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl) benzofuran-4-yloxy) pyrimidine-2 … JA Pfefferkorn, A Guzman-Perez, PJ Oates, J Litchfield, G Aspnes, ... MedChemComm 2 (9), 828-839, 2011 | 77 | 2011 |
| Substituted Pyrazoles as Hepatoselective HMG-CoA Reductase Inhibitors: Discovery of (3 R, 5 R)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2 H-pyrazol-3-yl … JA Pfefferkorn, C Choi, SD Larsen, B Auerbach, R Hutchings, W Park, ... Journal of medicinal chemistry 51 (1), 31-45, 2008 | 67 | 2008 |
| P2Y1 receptor antagonists as novel antithrombotic agents JA Pfefferkorn, C Choi, T Winters, R Kennedy, L Chi, LA Perrin, G Lu, ... Bioorganic & medicinal chemistry letters 18 (11), 3338-3343, 2008 | 56 | 2008 |
| Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors JA Pfefferkorn, C Choi, Y Song, BK Trivedi, SD Larsen, V Askew, L Dillon, ... Bioorganic & medicinal chemistry letters 17 (16), 4531-4537, 2007 | 48 | 2007 |
| Structurally Divergent Lithium Catalyzed Friedel–Crafts Reactions on Oxetan‐3‐ols: Synthesis of 3, 3‐Diaryloxetanes and 2, 3‐Dihydrobenzofurans RA Croft, JJ Mousseau, C Choi, JA Bull Chemistry–A European Journal 22 (45), 16271-16276, 2016 | 44 | 2016 |
| A formal catalytic asymmetric synthesis of (+)-biotin with modified cinchona alkaloids C Choi, SK Tian, L Deng Synthesis 2001 (11), 1737-1741, 2001 | 44 | 2001 |
| Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase LD Bratton, B Auerbach, C Choi, L Dillon, JC Hanselman, SD Larsen, ... Bioorganic & medicinal chemistry 15 (16), 5576-5589, 2007 | 43 | 2007 |
| Irradiation-induced palladium-catalyzed direct C–H alkylation of heteroarenes with tertiary and secondary alkyl bromides GZ Wang, R Shang, Y Fu Synthesis 50 (15), 2908-2914, 2018 | 42 | 2018 |
| Lithium‐Catalyzed Thiol Alkylation with Tertiary and Secondary Alcohols: Synthesis of 3‐Sulfanyl‐Oxetanes as Bioisosteres RA Croft, JJ Mousseau, C Choi, JA Bull Chemistry–A European Journal 24 (4), 818-821, 2018 | 34 | 2018 |
| Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors JA Pfefferkorn, DM Bowles, W Kissel, DC Boyles, C Choi, SD Larsen, ... Tetrahedron 63 (34), 8124-8134, 2007 | 34 | 2007 |
| PF-07059013: a noncovalent modulator of hemoglobin for treatment of sickle cell disease A Gopalsamy, AE Aulabaugh, A Barakat, KC Beaumont, S Cabral, ... Journal of Medicinal Chemistry 64 (1), 326-342, 2020 | 33 | 2020 |
| Design and evaluation of a 2-(2, 3, 6-trifluorophenyl) acetamide derivative as an agonist of the GPR119 receptor V Mascitti, BD Stevens, C Choi, KF McClure, CRW Guimarães, KA Farley, ... Bioorganic & medicinal chemistry letters 21 (5), 1306-1309, 2011 | 33 | 2011 |
| Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides JJ Rojas, RA Croft, AJ Sterling, EL Briggs, D Antermite, DC Schmitt, ... Nature chemistry 14 (2), 160-169, 2022 | 32 | 2022 |
| Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally … ME Schnute, M Wennerstål, J Alley, M Bengtsson, JR Blinn, CW Bolten, ... Journal of Medicinal Chemistry 61 (23), 10415-10439, 2018 | 31 | 2018 |
| Automated nanomole-scale reaction screening toward benzoate bioisosteres: a photocatalyzed approach to highly elaborated bicyclo [1.1. 1] pentanes JJ Mousseau, MA Perry, MW Bundesmann, GM Chinigo, C Choi, ... ACS Catalysis 12 (1), 600-606, 2021 | 26 | 2021 |
| Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors S Han, RM Czerwinski, NL Caspers, DC Limburg, WD Ding, H Wang, ... Biochemical Journal 460 (2), 211-222, 2014 | 25 | 2014 |
