Premature ageing in mice expressing defective mitochondrial DNA polymerase A Trifunovic, A Wredenberg, M Falkenberg, JN Spelbrink, AT Rovio, ... Nature 429 (6990), 417-423, 2004 | 3058 | 2004 |
Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA M Falkenberg, M Gaspari, A Rantanen, A Trifunovic, NG Larsson, ... Nature genetics 31 (3), 289-294, 2002 | 757 | 2002 |
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons MI Ekstrand, M Terzioglu, D Galter, S Zhu, C Hofstetter, E Lindqvist, ... Proceedings of the National Academy of Sciences 104 (4), 1325-1330, 2007 | 676 | 2007 |
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production A Trifunovic, A Hansson, A Wredenberg, AT Rovio, E Dufour, I Khvorostov, ... Proceedings of the National Academy of Sciences 102 (50), 17993-17998, 2005 | 645 | 2005 |
Obesity-induced CerS6-dependent C16: 0 ceramide production promotes weight gain and glucose intolerance SM Turpin, HT Nicholls, DM Willmes, A Mourier, S Brodesser, ... Cell metabolism 20 (4), 678-686, 2014 | 622 | 2014 |
Strong purifying selection in transmission of mammalian mitochondrial DNA JB Stewart, C Freyer, JL Elson, A Wredenberg, Z Cansu, A Trifunovic, ... PLoS biology 6 (1), e10, 2008 | 528 | 2008 |
Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology S Duvezin-Caubet, R Jagasia, J Wagener, S Hofmann, A Trifunovic, ... Journal of Biological Chemistry 281 (49), 37972-37979, 2006 | 495 | 2006 |
Mitochondrial dysfunction as a cause of ageing A Trifunovic, NG Larsson Journal of internal medicine 263 (2), 167-178, 2008 | 444 | 2008 |
Mitochondrial energy metabolism and ageing I Bratic, A Trifunovic Biochimica et Biophysica Acta (BBA)-Bioenergetics 1797 (6-7), 961-967, 2010 | 318 | 2010 |
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis N Hance, MI Ekstrand, A Trifunovic Human molecular genetics 14 (13), 1775-1783, 2005 | 298 | 2005 |
Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice D Edgar, I Shabalina, Y Camara, A Wredenberg, MA Calvaruso, ... Cell metabolism 10 (2), 131-138, 2009 | 286 | 2009 |
High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio JM Ross, J Öberg, S Brené, G Coppotelli, M Terzioglu, K Pernold, ... Proceedings of the National Academy of Sciences 107 (46), 20087-20092, 2010 | 277 | 2010 |
Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice KJ Ahlqvist, RH Hämäläinen, S Yatsuga, M Uutela, M Terzioglu, A Götz, ... Cell metabolism 15 (1), 100-109, 2012 | 263 | 2012 |
The CoQH2/CoQ ratio serves as a sensor of respiratory chain efficiency A Guaras, E Perales-Clemente, E Calvo, R Acín-Pérez, M Loureiro-Lopez, ... Cell reports 15 (1), 197-209, 2016 | 261 | 2016 |
Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart SA Dogan, C Pujol, P Maiti, A Kukat, S Wang, S Hermans, K Senft, ... Cell metabolism 19 (3), 458-469, 2014 | 214 | 2014 |
Mitochondrial DNA and ageing A Trifunovic Biochimica et Biophysica Acta (BBA)-Bioenergetics 1757 (5-6), 611-617, 2006 | 145 | 2006 |
CLPP coordinates mitoribosomal assembly through the regulation of ERAL 1 levels K Szczepanowska, P Maiti, A Kukat, E Hofsetz, H Nolte, K Senft, C Becker, ... The EMBO journal 35 (23), 2566-2583, 2016 | 141 | 2016 |
Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development I Bratic, J Hench, J Henriksson, A Antebi, TR Bürglin, A Trifunovic Nucleic acids research 37 (6), 1817-1828, 2009 | 123 | 2009 |
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing S Willenborg, DE Sanin, A Jais, X Ding, T Ulas, J Nüchel, M Popović, ... Cell metabolism 33 (12), 2398-2414. e9, 2021 | 106 | 2021 |
Spastin binds to lipid droplets and affects lipid metabolism C Papadopoulos, G Orso, G Mancuso, M Herholz, S Gumeni, N Tadepalle, ... PLoS genetics 11 (4), e1005149, 2015 | 104 | 2015 |