Zhan Yao
Zhan Yao
Loxo oncology at Lilly
Verifierad e-postadress på loxooncology.com
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TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
Z Yao, S Fenoglio, DC Gao, M Camiolo, B Stiles, T Lindsted, ...
Proceedings of the National Academy of Sciences 107 (35), 15535-15540, 2010
BRAF mutants evade ERK-dependent feedback by different mechanisms that determine their sensitivity to pharmacologic inhibition
Z Yao, NM Torres, A Tao, Y Gao, L Luo, Q Li, E de Stanchina, ...
Cancer cell 28 (3), 370-383, 2015
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
VS Rodrik-Outmezguine, M Okaniwa, Z Yao, CJ Novotny, C McWhirter, ...
Nature 534 (7606), 272-276, 2016
Diverse and targetable kinase alterations drive histiocytic neoplasms
EL Diamond, BH Durham, J Haroche, Z Yao, J Ma, SA Parikh, Z Wang, ...
Cancer discovery 6 (2), 154-165, 2016
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
Z Yao, R Yaeger, VS Rodrik-Outmezguine, A Tao, NM Torres, MT Chang, ...
Nature 548 (7666), 234-238, 2017
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence
MH Nissan, CA Pratilas, AM Jones, R Ramirez, H Won, C Liu, S Tiwari, ...
Cancer research 74 (8), 2340-2350, 2014
Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS–ERK signaling
M Will, ACR Qin, W Toy, Z Yao, V Rodrik-Outmezguine, C Schneider, ...
Cancer discovery 4 (3), 334-347, 2014
Extreme outlier analysis identifies occult mitogen-activated protein kinase pathway mutations in patients with low-grade serous ovarian cancer
RN Grisham, BE Sylvester, H Won, G McDermott, D DeLair, R Ramirez, ...
Journal of Clinical Oncology 33 (34), 4099, 2015
A Braf kinase-inactive mutant induces lung adenocarcinoma
P Nieto, C Ambrogio, L Esteban-Burgos, G Gómez-López, MT Blasco, ...
Nature 548 (7666), 239-243, 2017
Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin
J Xu, CG Pham, SK Albanese, Y Dong, T Oyama, CH Lee, ...
The Journal of clinical investigation 126 (9), 3526-3540, 2016
p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state
S Senturk, Z Yao, M Camiolo, B Stiles, T Rathod, AM Walsh, ...
Proceedings of the National Academy of Sciences 111 (32), E3287-E3296, 2014
RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling
Z Yao, Y Gao, W Su, R Yaeger, J Tao, N Na, Y Zhang, C Zhang, A Rymar, ...
Nature medicine 25 (2), 284-291, 2019
B23 acts as a nucleolar stress sensor and promotes cell survival through its dynamic interaction with hnRNPU and hnRNPA1
Z Yao, S Duan, D Hou, W Wang, G Wang, Y Liu, L Wen, M Wu
Oncogene 29 (12), 1821-1834, 2010
Phosphorylation of Pirh2 by Calmodulin‐dependent kinase II impairs its ability to ubiquitinate p53
S Duan, Z Yao, D Hou, Z Wu, W Zhu, M Wu
The EMBO journal 26 (13), 3062-3074, 2007
Allele-specific mechanisms of activation of MEK1 mutants determine their properties
Y Gao, MT Chang, D McKay, N Na, B Zhou, R Yaeger, NM Torres, ...
Cancer discovery 8 (5), 648-661, 2018
A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas
Y Sun, JA Alberta, C Pilarz, D Calligaris, EJ Chadwick, SH Ramkissoon, ...
Neuro-oncology 19 (6), 774-785, 2017
Mechanisms of acquired resistance to BRAF V600E inhibition in colon cancers converge on RAF dimerization and are sensitive to its inhibition
R Yaeger, Z Yao, DM Hyman, JF Hechtman, E Vakiani, HY Zhao, W Su, ...
Cancer research 77 (23), 6513-6523, 2017
Death effector domain DEDa, a self‐cleaved product of caspase‐8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase‐8 expression via a p53 …
Z Yao, S Duan, D Hou, K Heese, M Wu
The EMBO journal 26 (4), 1068-1080, 2007
A secondary mutation in BRAF confers resistance to RAF inhibition in a BRAF V600E-mutant brain tumor
J Wang, Z Yao, P Jonsson, AN Allen, ACR Qin, S Uddin, IJ Dunkel, ...
Cancer discovery 8 (9), 1130-1141, 2018
The Pirh2–keratin 8/18 interaction modulates the cellular distribution of mitochondria and UV-induced apoptosis
S Duan, Z Yao, Y Zhu, G Wang, D Hou, L Wen, M Wu
Cell Death & Differentiation 16 (6), 826-837, 2009
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