| Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases M Steger, F Tonelli, G Ito, P Davies, M Trost, M Vetter, S Wachter, ... elife 5, e12813, 2016 | 868 | 2016 |
| GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease G Ito, T Okai, GO Fujino, K Takeda, H Ichijo, T Katada, T Iwatsubo Biochemistry 46 (5), 1380-1388, 2007 | 332 | 2007 |
| LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis T Eguchi, T Kuwahara, M Sakurai, T Komori, T Fujimoto, G Ito, ... Proceedings of the National Academy of Sciences 115 (39), E9115-E9124, 2018 | 246 | 2018 |
| Lewy body pathology involves cutaneous nerves M Ikemura, Y Saito, R Sengoku, Y Sakiyama, H Hatsuta, K Kanemaru, ... Journal of Neuropathology & Experimental Neurology 67 (10), 945-953, 2008 | 232 | 2008 |
| Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors G Ito, K Katsemonova, F Tonelli, P Lis, MAS Baptista, N Shpiro, G Duddy, ... Biochemical Journal 473 (17), 2671-2685, 2016 | 159 | 2016 |
| Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils Y Fan, AJM Howden, AR Sarhan, P Lis, G Ito, TN Martinez, K Brockmann, ... Biochemical Journal 475 (1), 23-44, 2018 | 151 | 2018 |
| Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in lewy body disease Y Fumimura, M Ikemura, Y Saito, R Sengoku, K Kanemaru, M Sawabe, ... Journal of neuropathology and experimental neurology 66 (5), 354-362, 2007 | 147 | 2007 |
| Identification of the autophosphorylation sites of LRRK2 S Kamikawaji, G Ito, T Iwatsubo Biochemistry 48 (46), 10963-10975, 2009 | 138 | 2009 |
| Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1 S Takatori, G Ito, T Iwatsubo Neuroscience letters 430 (1), 13-17, 2008 | 135 | 2008 |
| Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans T Kuwahara, R Tonegawa, G Ito, S Mitani, T Iwatsubo Journal of Biological Chemistry 287 (10), 7098-7109, 2012 | 102 | 2012 |
| Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1 G Ito, H Ariga, Y Nakagawa, T Iwatsubo Biochemical and biophysical research communications 339 (2), 667-672, 2006 | 84 | 2006 |
| LRRK2 in Parkinson's disease and dementia with Lewy bodies X Zhu, A Babar, SL Siedlak, Q Yang, G Ito, T Iwatsubo, MA Smith, G Perry, ... Molecular Neurodegeneration 1, 1-9, 2006 | 68 | 2006 |
| Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor JM Hatcher, J Zhang, HG Choi, G Ito, DR Alessi, NS Gray ACS medicinal chemistry letters 6 (5), 584-589, 2015 | 60 | 2015 |
| Enhanced accumulation of phosphorylated α-synuclein and elevated β-amyloid 42/40 ratio caused by expression of the presenilin-1 ΔT440 mutant associated with familial Lewy body … H Kaneko, A Kakita, K Kasuga, H Nozaki, A Ishikawa, A Miyashita, ... Journal of Neuroscience 27 (48), 13092-13097, 2007 | 51 | 2007 |
| Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form G Ito, T Iwatsubo Biochemical Journal 441 (3), 987-998, 2012 | 50 | 2012 |
| Leucine-rich repeat kinase 2 colocalizes with α-synuclein in Parkinson’s disease, but not tau-containing deposits in tauopathies G Perry, X Zhu, AK Babar, SL Siedlak, Q Yang, G Ito, T Iwatsubo, ... Neurodegenerative Diseases 5 (3-4), 222-224, 2008 | 47 | 2008 |
| Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases. eLife 5 M Steger, F Tonelli, G Ito, P Davies, M Trost, M Vetter, S Wachter, ... JANUARY2016, 2016 | 39 | 2016 |
| Structural characterization of LRRK2 inhibitors BK Gilsbach, AC Messias, G Ito, M Sattler, DR Alessi, A Wittinghofer, ... Journal of medicinal chemistry 58 (9), 3751-3756, 2015 | 38 | 2015 |
| Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955 G Ito, T Fujimoto, S Kamikawaji, T Kuwahara, T Iwatsubo PLoS One 9 (5), e97988, 2014 | 37 | 2014 |
| Physiological and pathological functions of LRRK2: implications from substrate proteins M Araki, G Ito, T Tomita Neuronal Signaling 2 (4), NS20180005, 2018 | 27 | 2018 |
Takeshi IwatsuboProfessor of Neuropathology, The University of TokyoVerified email at m.u-tokyo.ac.jp
