Nadeem Siddiqui
Nadeem Siddiqui
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Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin
MR Fabian, F Frank, C Rouya, N Siddiqui, WS Lai, A Karetnikov, ...
Nature structural & molecular biology 20 (6), 735, 2013
Signalling to eIF4E in cancer
N Siddiqui, N Sonenberg
Biochemical Society Transactions 43 (5), 763-772, 2015
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies
T Alain, M Morita, BD Fonseca, A Yanagiya, N Siddiqui, M Bhat, D Zammit, ...
Cancer research 72 (24), 6468-6476, 2012
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development
M Morita, LW Ler, MR Fabian, N Siddiqui, M Mullin, VC Henderson, ...
Molecular and cellular biology 32 (17), 3585-3593, 2012
Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export‐competent RNP
I Topisirovic, N Siddiqui, VL Lapointe, M Trost, P Thibault, C Bangeranye, ...
The EMBO journal 28 (8), 1087-1098, 2009
Structural basis of ligand recognition by PABC, a highly specific peptide‐binding domain found in poly (A)‐binding protein and a HECT ubiquitin ligase
G Kozlov, G De Crescenzo, NS Lim, N Siddiqui, D Fantus, A Kahvejian, ...
The EMBO journal 23 (2), 272-281, 2004
mTOR controls mitochondrial dynamics and cell survival via MTFP1
M Morita, J Prudent, K Basu, V Goyon, S Katsumura, L Hulea, D Pearl, ...
Molecular cell 67 (6), 922-935. e5, 2017
Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1
C Rouya, N Siddiqui, M Morita, TF Duchaine, MR Fabian, N Sonenberg
Rna 20 (9), 1398-1409, 2014
mRNA export and cancer
N Siddiqui, KLB Borden
Wiley Interdisciplinary Reviews: RNA 3 (1), 13-25, 2012
Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer
I Topisirovic, N Siddiqui, S Orolicki, LA Skrabanek, M Tremblay, T Hoang, ...
Molecular and cellular biology 29 (5), 1152-1162, 2009
Cap‐free structure of eIF4E suggests a basis for conformational regulation by its ligands
L Volpon, MJ Osborne, I Topisirovic, N Siddiqui, KLB Borden
The EMBO journal 25 (21), 5138-5149, 2006
Poly (A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly (A)-binding protein
N Siddiqui, DA Mangus, TC Chang, JM Palermino, AB Shyu, K Gehring
Journal of Biological Chemistry 282 (34), 25067-25075, 2007
Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly (A)-binding protein: implications for HYD function
NS Lim, G Kozlov, TC Chang, O Groover, N Siddiqui, L Volpon, ...
Journal of Biological Chemistry 281 (20), 14376-14382, 2006
Structural insights into the allosteric effects of 4EBP1 on the eukaryotic translation initiation factor eIF4E
N Siddiqui, W Tempel, L Nedyalkova, L Volpon, AK Wernimont, ...
Journal of molecular biology 415 (5), 781-792, 2012
Solution Structure of the Orphan PABC Domain fromSaccharomyces cerevisiae Poly (A)-binding Protein
G Kozlov, N Siddiqui, S Coillet-Matillon, JF Trempe, I Ekiel, T Sprules, ...
Journal of Biological Chemistry 277 (25), 22822-22828, 2002
Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex
MA Roy, N Siddiqui, D D'Amours
Cell Cycle 10 (4), 690-700, 2011
Structure of the archaeal translation initiation factor aIF2β from Methanobacterium thermoautotrophicum: Implications for translation initiation
P Gutiérrez, MJ Osborne, N Siddiqui, JF Trempe, C Arrowsmith, K Gehring
Protein Science 13 (3), 659-667, 2004
Conformation change in a self-recognizing autotransporter modulates bacterial cell-cell interaction
V Girard, JP Côté, MÈ Charbonneau, M Campos, F Berthiaume, ...
Journal of Biological Chemistry 285 (14), 10616-10626, 2010
Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster
G Hernández, M Miron, H Han, N Liu, J Magescas, G Tettweiler, F Frank, ...
Molecular and cellular biology 33 (15), 2854-2864, 2013
The eukaryotic translation initiation factor 4E (eIF4E) and HuR RNA operons collaboratively regulate the expression of survival and proliferative genes
I Topisirovic, N Siddiqui, KLB Borden
Cell Cycle 8 (7), 959-964, 2009
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