ke Ding
ke Ding
Verifierad e-postadress på jnu.edu.cn
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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
S Shangary, D Qin, D McEachern, M Liu, RS Miller, S Qiu, ...
Proceedings of the National Academy of Sciences 105 (10), 3933-3938, 2008
6962008
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2− p53 interaction
K Ding, Y Lu, Z Nikolovska-Coleska, G Wang, S Qiu, S Shangary, W Gao, ...
Journal of medicinal chemistry 49 (12), 3432-3435, 2006
6822006
Structure-based design of potent non-peptide MDM2 inhibitors
K Ding, Y Lu, Z Nikolovska-Coleska, S Qiu, Y Ding, W Gao, J Stuckey, ...
Journal of the American Chemical Society 127 (29), 10130-10131, 2005
6252005
Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-κB pathway and generation of reactive oxygen species
Y Jin, Z Lu, K Ding, J Li, X Du, C Chen, X Sun, Y Wu, J Zhou, J Pan
Cancer research 70 (6), 2516-2527, 2010
2572010
Potent and orally active small-molecule inhibitors of the MDM2− p53 interaction
S Yu, D Qin, S Shangary, J Chen, G Wang, K Ding, D McEachern, S Qiu, ...
Journal of medicinal chemistry 52 (24), 7970-7973, 2009
1742009
Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway
X Ren, L Duan, Q He, Z Zhang, Y Zhou, D Wu, J Pan, D Pei, K Ding
ACS medicinal chemistry letters 1 (9), 454-459, 2010
1512010
Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia
CP Guise, AM Mowday, A Ashoorzadeh, R Yuan, WH Lin, DH Wu, ...
Chinese journal of cancer 33 (2), 80, 2014
1372014
Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1
X Hui, H Li, Z Zhou, KSL Lam, Y Xiao, D Wu, K Ding, Y Wang, ...
Journal of Biological Chemistry 285 (14), 10273-10280, 2010
1372010
BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone
J Chen, J Liu, J Yang, Y Chen, J Chen, S Ni, H Song, L Zeng, K Ding, ...
Cell research 21 (1), 205-212, 2011
1352011
Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein
H Cheng, J Wan, MI Lin, Y Liu, X Lu, J Liu, Y Xu, J Chen, Z Tu, ...
Journal of medicinal chemistry 55 (5), 2144-2153, 2012
1282012
Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine790→ methionine790 mutant
S Chang, L Zhang, S Xu, J Luo, X Lu, Z Zhang, T Xu, Y Liu, Z Tu, Y Xu, ...
Journal of medicinal chemistry 55 (6), 2711-2723, 2012
1222012
(2-Pyridyl) acetone-promoted Cu-catalyzed O-arylation of phenols with aryl iodides, bromides, and chlorides
Q Zhang, D Wang, X Wang, K Ding
The Journal of Organic Chemistry 74 (18), 7187-7190, 2009
1192009
An Efficient Copper‐Catalyzed Amination of Aryl Halides by Aqueous Ammonia
D Wang, Q Cai, K Ding
Advanced Synthesis & Catalysis 351 (11‐12), 1722-1726, 2009
1192009
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma
C Ambrogio, G Gómez-López, M Falcone, A Vidal, E Nadal, N Crosetto, ...
Nature medicine 22 (3), 270-277, 2016
1112016
Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer
S Shangary, K Ding, S Qiu, Z Nikolovska-Coleska, JA Bauer, M Liu, ...
Molecular cancer therapeutics 7 (6), 1533-1542, 2008
1032008
Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells
JX Pan, K Ding, CY Wang
Chinese journal of cancer 31 (4), 178, 2012
1022012
Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 …
M Gao, L Duan, J Luo, L Zhang, X Lu, Y Zhang, Z Zhang, Z Tu, Y Xu, ...
Journal of medicinal chemistry 56 (8), 3281-3295, 2013
1002013
MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53
JA Canner, M Sobo, S Ball, B Hutzen, S DeAngelis, W Willis, ...
British journal of cancer 101 (5), 774-781, 2009
862009
Copper-catalyzed desymmetric intramolecular Ullmann C–N coupling: an enantioselective preparation of indolines
F Zhou, J Guo, J Liu, K Ding, S Yu, Q Cai
Journal of the American Chemical Society 134 (35), 14326-14329, 2012
832012
Palladium‐Catalyzed Amidation of N‐Tosylhydrazones with Isocyanides
F Zhou, K Ding, Q Cai
Chemistry–A European Journal 17 (44), 12268-12271, 2011
792011
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Artiklar 1–20