| Synthetic genetic polymers capable of heredity and evolution VB Pinheiro, AI Taylor, C Cozens, M Abramov, M Renders, S Zhang, ... Science 336 (6079), 341-344, 2012 | 766 | 2012 |
| Analysis of aptamer discovery and technology MR Dunn, RM Jimenez, JC Chaput Nature Reviews Chemistry 1 (10), 0076, 2017 | 671 | 2017 |
| Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor H Yu, S Zhang, JC Chaput Nature chemistry 4 (3), 183-187, 2012 | 286 | 2012 |
| Random mutagenesis by error-prone PCR EO McCullum, BAR Williams, J Zhang, JC Chaput In Vitro Mutagenesis Protocols: Third Edition, 103-109, 2010 | 234 | 2010 |
| Self-assembled peptide nanoarrays: a new approach to studying protein-protein interactions BAR Williams, K Lund, Y Liu, H Yan, JC Chaput Angew. Chem. Int. Ed 46 (17), 3051-3054, 2007 | 183 | 2007 |
| TNA synthesis by DNA polymerases JC Chaput, JW Szostak Journal of the American Chemical Society 125 (31), 9274-9275, 2003 | 177 | 2003 |
| The structural diversity of artificial genetic polymers I Anosova, EA Kowal, MR Dunn, JC Chaput, WD Van Horn, M Egli Nucleic acids research 44 (3), 1007-1021, 2015 | 169 | 2015 |
| A general strategy for expanding polymerase function by droplet microfluidics AC Larsen, MR Dunn, A Hatch, SP Sau, C Youngbull, JC Chaput Nature Communications 7 (1), 11235, 2016 | 167 | 2016 |
| DNA polymerase-mediated DNA synthesis on a TNA template JC Chaput, JK Ichida, JW Szostak Journal of the American Chemical Society 125 (4), 856-857, 2003 | 159 | 2003 |
| A DNA pentaplex incorporating nucleobase quintets JC Chaput, C Switzer Proceedings of the National Academy of Sciences 96 (19), 10614-10619, 1999 | 153 | 1999 |
| Creating protein affinity reagents by combining peptide ligands on synthetic DNA scaffolds BAR Williams, CW Diehnelt, P Belcher, M Greving, NW Woodbury, ... Journal of the American Chemical Society 131 (47), 17233-17241, 2009 | 135 | 2009 |
| Kinetic analysis of an efficient DNA-dependent TNA polymerase A Horhota, K Zou, JK Ichida, B Yu, LW McLaughlin, JW Szostak, ... Journal of the American Chemical Society 127 (20), 7427-7434, 2005 | 123 | 2005 |
| A biologically stable DNAzyme that efficiently silences gene expression in cells Y Wang, K Nguyen, RC Spitale, JC Chaput Nature Chemistry 13 (4), 319-326, 2021 | 121 | 2021 |
| The emerging world of synthetic genetics JC Chaput, H Yu, S Zhang Chemistry & biology 19 (11), 1360-1371, 2012 | 103 | 2012 |
| Template-directed nucleation and growth of inorganic nanoparticles on DNA scaffolds LA Stearns, R Chhabra, J Sharma, Y Liu, W Petuskey, H Yan, JC Chaput Angewandte Chemie-International Edition 48 (45), 8494-8496, 2009 | 102 | 2009 |
| Fluorescence-activated droplet sorting for single-cell directed evolution D Vallejo, A Nikoomanzar, BM Paegel, JC Chaput ACS synthetic biology 8 (6), 1430-1440, 2019 | 100 | 2019 |
| An efficient and faithful in vitro replication system for threose nucleic acid H Yu, S Zhang, MR Dunn, JC Chaput Journal of the American Chemical Society 135 (9), 3583-3591, 2013 | 99 | 2013 |
| Synthesis and evolution of a threose nucleic acid aptamer bearing 7-deaza-7-substituted guanosine residues H Mei, JY Liao, RM Jimenez, Y Wang, S Bala, C McCloskey, C Switzer, ... Journal of the American Chemical Society 140 (17), 5706-5713, 2018 | 87 | 2018 |
| Generating biologically stable TNA aptamers that function with high affinity and thermal stability MR Dunn, CM McCloskey, P Buckley, K Rhea, JC Chaput Journal of the American Chemical Society 142 (17), 7721-7724, 2020 | 85 | 2020 |
| Improving polymerase activity with unnatural substrates by sampling mutations in homologous protein architectures MR Dunn, C Otto, KE Fenton, JC Chaput ACS chemical biology 11 (5), 1210-1219, 2016 | 84 | 2016 |
