| Batch versus flow photochemistry: a revealing comparison of yield and productivity LD Elliott, JP Knowles, PJ Koovits, KG Maskill, MJ Ralph, G Lejeune, ... Chemistry–A European Journal 20 (46), 15226-15232, 2014 | 223 | 2014 |
| Photons as a 21st century reagent HE Bonfield, T Knauber, F Lévesque, EG Moschetta, F Susanne, ... Nature Communications 11 (1), 804, 2020 | 140 | 2020 |
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: A Potent, Orally Bioavailable Human CB1/CB2 Dual Agonist with Antihyperalgesic Properties and … EK Dziadulewicz, SJ Bevan, CT Brain, PR Coote, AJ Culshaw, AJ Davis, ... Journal of medicinal chemistry 50 (16), 3851-3856, 2007 | 120 | 2007 |
| Photocatalytic α‐Tertiary Amine Synthesis via C− H Alkylation of Unmasked Primary Amines ASH Ryder, WB Cunningham, G Ballantyne, T Mules, AG Kinsella, ... Angewandte Chemie 132 (35), 15096-15101, 2020 | 108 | 2020 |
| Pyridine and pyrazine derivative for the treatment of CF U Baettig, KJ Bala, E Budd, L Edwards, C Howsham, G Hughes, ... US Patent 8,247,436, 2012 | 82 | 2012 |
| Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain AJ Culshaw, S Bevan, M Christiansen, P Copp, A Davis, C Davis, ... Journal of medicinal chemistry 49 (2), 471-474, 2006 | 73 | 2006 |
| The right light: de novo design of a robust modular photochemical reactor for optimum batch and flow chemistry HE Bonfield, K Mercer, A Diaz‐Rodriguez, GC Cook, BSJ McKay, P Slade, ... ChemPhotoChem 4 (1), 45-51, 2020 | 58 | 2020 |
| Chromoselective photocatalysis enables stereocomplementary biocatalytic pathways L Schmermund, S Reischauer, S Bierbaumer, CK Winkler, ... Angewandte Chemie 133 (13), 7041-7045, 2021 | 57 | 2021 |
| An organophotocatalytic late-stage N–CH 3 oxidation of trialkylamines to N-formamides with O 2 in continuous flow MJP Mandigma, J Žurauskas, CI MacGregor, LJ Edwards, A Shahin, ... Chemical Science 13 (7), 1912-1924, 2022 | 32 | 2022 |
| Development and scale-up of continuous electrocatalytic hydrogenation of functionalized nitro arenes, nitriles, and unsaturated aldehydes JD Egbert, EC Thomsen, SA O’Neill-Slawecki, DM Mans, DC Leitch, ... Organic Process Research & Development 23 (9), 1803-1812, 2019 | 29 | 2019 |
| Pyridine and pyrazine derivative for the treatment of CF U Baettig, KJ Bala, E Budd, L Edwards, C Howsham, GA Hughes, ... US Patent 8,476,269, 2013 | 29 | 2013 |
| A detailed study of irradiation requirements towards an efficient photochemical Wohl‐Ziegler procedure in flow HE Bonfield, JD Williams, WX Ooi, SG Leach, WJ Kerr, LJ Edwards ChemPhotoChem 2 (10), 938-944, 2018 | 28 | 2018 |
| Organic compounds I Bruce, E Budd, L Edwards, C Howsham US Patent App. 12/380,901, 2009 | 25 | 2009 |
| Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive … DL Grand, M Gosling, U Baettig, P Bahra, K Bala, C Brocklehurst, E Budd, ... Journal of Medicinal Chemistry 64 (11), 7241–7260, 2021 | 20 | 2021 |
| Evaluation and screening of spherical Pd/C for use as a catalyst in pharmaceutical-scale continuous hydrogenations E Fernandez-Puertas, AJ Robinson, H Robinson, S Sathiyalingam, ... Organic Process Research & Development 24 (10), 2147-2156, 2020 | 19 | 2020 |
| Fixed bed continuous hydrogenations in trickle flow mode: A pharmaceutical industry perspective E Masson, EM Maciejewski, KMP Wheelhouse, LJ Edwards Organic Process Research & Development 26 (8), 2190-2223, 2022 | 17 | 2022 |
| Evaluation of sponge metal catalysts in a trickle bed reactor for the continuous hydrogenation of an aliphatic nitro intermediate A Carangio, LJ Edwards, E Fernandez-Puertas, JF Hayes, MM Kucharski, ... Organic Process Research & Development 24 (10), 1909-1915, 2020 | 16 | 2020 |
| Pyrazine-2-carboxamide derivatives to treat diseases mediated by blockade of the epithelial sodium channel G Bhalay, E Budd, GC Bloomfield, SP Collingwood, A Dunstan, ... US Patent 8,039,472, 2011 | 13 | 2011 |
| Use of lithium diisopropylamide in flow: operability and safety challenges encountered on a multigram scale M Alonso, MC Garcia, C McKay, LR Thorp, M Webb, LJ Edwards Organic Process Research & Development 25 (4), 988-1000, 2021 | 9 | 2021 |
| Pyrazolo [3, 4-D] pyrimidine derivatives useful to treat respiratory disorders GC Bloomfield, I Bruce, B Cox, L Edwards, JF Hayler, C Howsham US Patent 8,901,134, 2014 | 7 | 2014 |
