Della C. David
Della C. David
Group Leader, Babraham Institute
Verified email at - Homepage
Cited by
Cited by
Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans
DC David, N Ollikainen, JC Trinidad, MP Cary, AL Burlingame, C Kenyon
PLoS biology 8 (8), e1000450, 2010
Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice
DC David, S Hauptmann, I Scherping, K Schuessel, U Keil, P Rizzu, ...
Journal of Biological Chemistry 280 (25), 23802-23814, 2005
Proteasomal degradation of tau protein
DC David, R Layfield, L Serpell, Y Narain, M Goedert, MG Spillantini
Journal of neurochemistry 83 (1), 176-185, 2002
Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy
J Götz, JR Streffer, D David, A Schild, F Hoerndli, L Pennanen, ...
Molecular psychiatry 9 (7), 664-683, 2004
Posttranslational modifications of tau-Role in human tauopathies and modeling in transgenic animals
F Chen, D David, A Ferrari, J Gotz
Current drug targets 5 (6), 503-515, 2004
Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing
IE Jansen, H Ye, S Heetveld, MC Lechler, H Michels, RI Seinstra, ...
Genome biology 18, 1-26, 2017
Animal models reveal role for tau phosphorylation in human disease
J Götz, A Gladbach, L Pennanen, J van Eersel, A Schild, D David, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1802 (10 …, 2010
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease
RJ Wheeler, HO Lee, I Poser, A Pal, T Doeleman, S Kishigami, S Kour, ...
Aging and the aggregating proteome
DC David
Frontiers in genetics 3, 32817, 2012
Reduced insulin/IGF-1 signaling restores the dynamic properties of key stress granule proteins during aging
MC Lechler, ED Crawford, N Groh, K Widmaier, R Jung, J Kirstein, ...
Cell reports 18 (2), 454-467, 2017
β‐Amyloid treatment of two complementary P301L tau‐expressing Alzheimer's disease models reveals similar deregulated cellular processes
DC David, LM Ittner, P Gehrig, D Nergenau, C Shepherd, G Halliday, ...
Proteomics 6 (24), 6566-6577, 2006
Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis
ED Crawford, JE Seaman, AE Barber, DC David, PC Babbitt, ...
Cell Death & Differentiation 19 (12), 2040-2048, 2012
Age-dependent protein aggregation initiates amyloid-β aggregation
N Groh, A Bühler, C Huang, KW Li, P van Nierop, AB Smit, M Fändrich, ...
Frontiers in aging neuroscience 9, 138, 2017
Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans
C Huang, S Wagner-Valladolid, AD Stephens, R Jung, C Poudel, ...
Elife 8, e43059, 2019
Extracellular proteostasis prevents aggregation during pathogenic attack
I Gallotta, A Sandhu, M Peters, M Haslbeck, R Jung, S Agilkaya, ...
Nature 584 (7821), 410-414, 2020
Functional Genomics meets neurodegenerative disorders: part II: application and data integration
F Hoerndli, DC David, J Götz
Progress in neurobiology 76 (3), 169-188, 2005
Functional Genomics meets neurodegenerative disorders: part I: transcriptomic and proteomic technology
DC David, F Hoerndli, J Götz
Progress in neurobiology 76 (3), 153-168, 2005
More stressed out with age? Check your RNA granule aggregation
MC Lechler, DC David
Prion 11 (5), 313-322, 2017
Functional genomics dissects pathomechanisms in tauopathies: Mitosis failure and unfolded protein response
J Götz, D David, F Hoerndli, YD Ke, N Schonrock, A Wiesner, T Fath, ...
Neurodegenerative Diseases 5 (3-4), 179-181, 2008
Methods to study changes in inherent protein aggregation with age in Caenorhabditis elegans
N Groh, I Gallotta, MC Lechler, C Huang, R Jung, DC David
JoVE (Journal of Visualized Experiments), e56464, 2017
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