| Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans DC David, N Ollikainen, JC Trinidad, MP Cary, AL Burlingame, C Kenyon PLoS biology 8 (8), e1000450, 2010 | 702 | 2010 |
| Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice DC David, S Hauptmann, I Scherping, K Schuessel, U Keil, P Rizzu, ... Journal of Biological Chemistry 280 (25), 23802-23814, 2005 | 470 | 2005 |
| Proteasomal degradation of tau protein DC David, R Layfield, L Serpell, Y Narain, M Goedert, MG Spillantini Journal of neurochemistry 83 (1), 176-185, 2002 | 412 | 2002 |
| Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy J Götz, JR Streffer, D David, A Schild, F Hoerndli, L Pennanen, ... Molecular psychiatry 9 (7), 664-683, 2004 | 378 | 2004 |
| Posttranslational modifications of tau-Role in human tauopathies and modeling in transgenic animals F Chen, D David, A Ferrari, J Gotz Current drug targets 5 (6), 503-515, 2004 | 133 | 2004 |
| Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing IE Jansen, H Ye, S Heetveld, MC Lechler, H Michels, RI Seinstra, ... Genome biology 18, 1-26, 2017 | 120 | 2017 |
| Animal models reveal role for tau phosphorylation in human disease J Götz, A Gladbach, L Pennanen, J van Eersel, A Schild, D David, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1802 (10 …, 2010 | 107 | 2010 |
| Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease RJ Wheeler, HO Lee, I Poser, A Pal, T Doeleman, S Kishigami, S Kour, ... | 93 | 2019 |
| Aging and the aggregating proteome DC David Frontiers in genetics 3, 247, 2012 | 90 | 2012 |
| Reduced insulin/IGF-1 signaling restores the dynamic properties of key stress granule proteins during aging MC Lechler, ED Crawford, N Groh, K Widmaier, R Jung, J Kirstein, ... Cell reports 18 (2), 454-467, 2017 | 79 | 2017 |
| β‐Amyloid treatment of two complementary P301L tau‐expressing Alzheimer's disease models reveals similar deregulated cellular processes DC David, LM Ittner, P Gehrig, D Nergenau, C Shepherd, G Halliday, ... Proteomics 6 (24), 6566-6577, 2006 | 76 | 2006 |
| Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis ED Crawford, JE Seaman, AE Barber, DC David, PC Babbitt, ... Cell Death & Differentiation 19 (12), 2040-2048, 2012 | 65 | 2012 |
| Age-dependent protein aggregation initiates amyloid-β aggregation N Groh, A Bühler, C Huang, KW Li, P van Nierop, AB Smit, M Fändrich, ... Frontiers in aging neuroscience 9, 138, 2017 | 64 | 2017 |
| Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans C Huang, S Wagner-Valladolid, AD Stephens, R Jung, C Poudel, ... Elife 8, e43059, 2019 | 57 | 2019 |
| Extracellular proteostasis prevents aggregation during pathogenic attack I Gallotta, A Sandhu, M Peters, M Haslbeck, R Jung, S Agilkaya, ... Nature 584 (7821), 410-414, 2020 | 53 | 2020 |
| Functional Genomics meets neurodegenerative disorders: part II: application and data integration F Hoerndli, DC David, J Götz Progress in neurobiology 76 (3), 169-188, 2005 | 49 | 2005 |
| Functional Genomics meets neurodegenerative disorders: part I: transcriptomic and proteomic technology DC David, F Hoerndli, J Götz Progress in neurobiology 76 (3), 153-168, 2005 | 44 | 2005 |
| More stressed out with age? Check your RNA granule aggregation MC Lechler, DC David Prion 11 (5), 313-322, 2017 | 26 | 2017 |
| Functional genomics dissects pathomechanisms in tauopathies: Mitosis failure and unfolded protein response J Götz, D David, F Hoerndli, YD Ke, N Schonrock, A Wiesner, T Fath, ... Neurodegenerative Diseases 5 (3-4), 179-181, 2008 | 11 | 2008 |
| Methods to study changes in inherent protein aggregation with age in Caenorhabditis elegans N Groh, I Gallotta, MC Lechler, C Huang, R Jung, DC David JoVE (Journal of Visualized Experiments), e56464, 2017 | 9 | 2017 |
