SARM1 is a multi-functional NAD (P) ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites C Angeletti, A Amici, J Gilley, A Loreto, AG Trapanotto, C Antoniou, ... Iscience 25 (2), 2022 | 56 | 2022 |
Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration A Pristerà, C Blomeley, E Lopes, S Threlfell, E Merlini, D Burdakov, ... Proceedings of the National Academy of Sciences 116 (9), 3817-3826, 2019 | 55 | 2019 |
Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain HC Feldman, E Merlini, C Guijas, KE DeMeester, E Njomen, EM Kozina, ... Proceedings of the National Academy of Sciences 119 (35), e2208457119, 2022 | 40 | 2022 |
Mitochondrial dysfunction as a trigger of programmed axon death E Merlini, MP Coleman, A Loreto Trends in Neurosciences 45 (1), 53-63, 2022 | 38 | 2022 |
Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1 A Loreto, C Angeletti, W Gu, A Osborne, B Nieuwenhuis, J Gilley, ... Elife 10, e72823, 2021 | 29 | 2021 |
Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity A Loreto, C Angeletti, W Gu, A Osborne, B Nieuwenhuis, J Gilley, ... BioRxiv, 2020.09. 18.304261, 2020 | 15 | 2020 |
NMN: The NAD precursor at the intersection between axon degeneration and anti-ageing therapies A Loreto, C Antoniou, E Merlini, J Gilley, MP Coleman Neuroscience Research 197, 18-24, 2023 | 10 | 2023 |
Social network dynamics throughout clinical training—Distance matters L Badawy, P Oza, R Shankarghatta, E Merlini Medical Education 55 (4), 541-541, 2021 | 3 | 2021 |
Programmed axon death: a promising target for treating retinal and optic nerve disorders A Loreto, E Merlini, MP Coleman Eye, 1-8, 2024 | | 2024 |
Programmed Axon Death: A Promising Target for Treating Retinal and Optic Nerve Disorders M Coleman, A Loreto, E Merlini Springer Nature [academic journals on nature. com], 2024 | | 2024 |
SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides A Loreto, KML Cramb, LA McDermott, C Antoniou, I Cirilli, MC Caiazza, ... bioRxiv, 2024.04. 02.587827, 2024 | | 2024 |
Chronically low NMNAT2 expression causes sub-lethal SARM1 activation and altered response to nicotinamide riboside in axons C Antoniou, A Loreto, J Gilley, E Merlini, G Orsomando, MP Coleman bioRxiv, 2024.03. 14.584798, 2024 | | 2024 |