| KDM5B regulates embryonic stem cell self‐renewal and represses cryptic intragenic transcription L Xie, C Pelz, W Wang, A Bashar, O Varlamova, S Shadle, S Impey The EMBO journal 30 (8), 1473-1484, 2011 | 178 | 2011 |
| Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells S Jagannathan, SC Shadle, R Resnick, L Snider, RN Tawil, ... Human Molecular Genetics 25 (20), 4419-4431, 2016 | 99 | 2016 |
| DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy SC Shadle, JW Zhong, AE Campbell, ML Conerly, S Jagannathan, ... PLoS Genetics 13 (3), e1006658, 2017 | 96 | 2017 |
| DUX4 suppresses MHC class I to promote cancer immune evasion and resistance to checkpoint blockade GL Chew, AE Campbell, E De Neef, NA Sutliff, SC Shadle, SJ Tapscott, ... Developmental cell 50 (5), 658-671. e7, 2019 | 92 | 2019 |
| p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models EJ Grow, BD Weaver, CM Smith, J Guo, P Stein, SC Shadle, ... Nature genetics 53 (8), 1207-1220, 2021 | 64 | 2021 |
| Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4 J Balog, PE Thijssen, S Shadle, KR Straasheijm, PJ van der Vliet, ... Epigenetics 10 (12), 1133-1142, 2015 | 63 | 2015 |
| NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins AE Campbell, SC Shadle, S Jagannathan, JW Lim, R Resnick, R Tawil, ... Elife 7, e31023, 2018 | 60 | 2018 |
| BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells AE Campbell, J Oliva, MP Yates, JW Zhong, SC Shadle, L Snider, ... Skeletal muscle 7, 1-18, 2017 | 58 | 2017 |
| Facioscapulohumeral dystrophy: activating an early embryonic transcriptional program in human skeletal muscle AE Campbell, AE Belleville, R Resnick, SC Shadle, SJ Tapscott Human molecular genetics 27 (R2), R153-R162, 2018 | 48 | 2018 |
| DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double-stranded RNA foci in human cell models of FSHD SC Shadle, SR Bennett, CJ Wong, NA Karreman, AE Campbell, ... Human molecular genetics 28 (23), 3997-4011, 2019 | 35 | 2019 |
| Multiple repeat regions within mouse DUX recruit chromatin regulators to facilitate an embryonic gene expression program CM Smith, EJ Grow, SC Shadle, BR Cairns bioRxiv, 2023 | 3 | 2023 |
| Chromatin Reprogramming of In Vitro Fertilized and Somatic Cell Nuclear Transfer Bovine Embryos During Embryonic Genome Activation EJ Grow, Y Liu, Z Fan, IV Perisse, T Patrick, M Regouski, S Shadle, ... bioRxiv, 2023.04. 10.536281, 2023 | | 2023 |
| Methods for treating facioscapulohumeral muscular dystrophy SJ Tapscott, S Shadle, A Campbell US Patent App. 16/966,823, 2021 | | 2021 |
| Mechanisms of toxicity in cell models of FSHD S Shadle | | 2018 |
