| Dimerization and domain swapping in G-protein-coupled receptors: a computational study PR Gouldson, C Higgs, RE Smith, MK Dean, GV Gkoutos, CA Reynolds Neuropsychopharmacology 23 (4), S60-S77, 2000 | 183 | 2000 |
| Dimerization of G-protein-coupled receptors MK Dean, C Higgs, RE Smith, RP Bywater, CR Snell, PD Scott, ... Journal of medicinal chemistry 44 (26), 4595-4614, 2001 | 175 | 2001 |
| Domain swapping in G-protein coupled receptor dimers. PR Gouldson, CR Snell, RP Bywater, C Higgs, CA Reynolds Protein engineering 11 (12), 1181-1193, 1998 | 157 | 1998 |
| A role for a specific cholesterol interaction in stabilizing the Apo configuration of the human A2A adenosine receptor E Lyman, C Higgs, B Kim, D Lupyan, JC Shelley, R Farid, GA Voth Structure 17 (12), 1660-1668, 2009 | 124 | 2009 |
| Hydration site thermodynamics explain SARs for triazolylpurines analogues binding to the A2A receptor C Higgs, T Beuming, W Sherman ACS medicinal chemistry letters 1 (4), 160-164, 2010 | 117 | 2010 |
| A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor DE Clark, C Higgs, SP Wren, HJ Dyke, M Wong, D Norman, PM Lockey, ... Journal of medicinal chemistry 47 (16), 3962-3971, 2004 | 102 | 2004 |
| Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes JM Sutton, DE Clark, SJ Dunsdon, G Fenton, A Fillmore, NV Harris, ... Bioorganic & medicinal chemistry letters 22 (3), 1464-1468, 2012 | 86 | 2012 |
| Benchmarking refined and unrefined AlphaFold2 structures for hit discovery Y Zhang, M Vass, D Shi, E Abualrous, JM Chambers, N Chopra, C Higgs, ... Journal of Chemical Information and Modeling 63 (6), 1656-1667, 2023 | 47 | 2023 |
| Discovery of potent, selective, and orally bioavailable inhibitors of USP7 with in vivo antitumor activity PR Leger, DX Hu, B Biannic, M Bui, X Han, E Karbarz, J Maung, A Okano, ... Journal of Medicinal Chemistry 63 (10), 5398-5420, 2020 | 45 | 2020 |
| Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists S Cramp, HJ Dyke, C Higgs, DE Clark, M Gill, P Savy, N Jennings, S Price, ... Bioorganic & Medicinal Chemistry Letters 20 (8), 2516-2519, 2010 | 36 | 2010 |
| Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors SA Ramachandran, PS Jadhavar, SK Miglani, MP Singh, DP Kalane, ... Bioorganic & Medicinal Chemistry Letters 27 (10), 2153-2160, 2017 | 22 | 2017 |
| Evidence for dimerization in the β2‐adrenergic receptor from the evolutionary trace method GV Gkoutos, C Higgs, RP Bywater, PR Gouldson, CA Reynolds International journal of quantum chemistry 74 (3), 371-379, 1999 | 15 | 1999 |
| Pyrimidine Compounds as Histamine Modulators N Harris, C Higgs, S Wren, H Dyke, S Price, S Cramp US Patent App. 11/667,301, 2008 | 11 | 2008 |
| Modelling G-protein coupled receptors C Higgs, CA Reynolds Theoretical biochemistry-processes and properties of biological systems 9 …, 2001 | 9 | 2001 |
| From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor J Sutton, DE Clark, C Higgs, MJ de Groot, NV Harris, A Taylor, PM Lockey, ... Bioorganic & Medicinal Chemistry Letters 24 (9), 2212-2221, 2014 | 8 | 2014 |
| Pyrimidine compounds as histamine modulators N Harris, C Higgs, S Wren, HJ Dyke, S Price, S Cramp | 6 | 2006 |
| Silicon Diols: Effective Inhibitors of Human Leukocyte Elastase GA Showell, JG Montana, JA Chadwick, C Higgs, HJ Hunt, RE MacKenzie, ... ChemInform 40 (9), no-no, 2009 | 5 | 2009 |
| G; Howe, TJ; Reynolds, С. A MK Dean, C Higgs, RE Smith, RP Bywater, СR Snell, PD Scott, GJ Upton J. Med. Chem 44, 4595-4614, 2001 | 3 | 2001 |
| Neuropsychopharmacology23, s60− s77 PR Gouldson, C Higgs, RE Smith, MK Dean, GV Gkoutos, CA Reynolds Google Scholar There is no corresponding record for this reference, 2000 | 2 | 2000 |
| Ligand‐based Rational Design: Virtual Screening DE Clark, C Higgs Ligand Design for G Protein‐coupled Receptors, 165-182, 2006 | 1 | 2006 |
