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| Structural insight into the autoinhibition mechanism of AMP-activated protein kinase L Chen, ZH Jiao, LS Zheng, YY Zhang, ST Xie, ZX Wang, JW Wu Nature 459 (7250), 1146-1149, 2009 | 225 | 2009 |
| Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states KL Dürr, L Chen, RA Stein, R De Zorzi, IM Folea, T Walz, HS Mchaourab, ... Cell 158 (4), 778-792, 2014 | 224 | 2014 |
| Structure of the receptor-activated human TRPC6 and TRPC3 ion channels Q Tang, W Guo, L Zheng, JX Wu, M Liu, X Zhou, X Zhang, L Chen Cell research 28 (7), 746-755, 2018 | 179 | 2018 |
| Structure of the mechanosensitive OSCA channels M Zhang, D Wang, Y Kang, JX Wu, F Yao, C Pan, Z Yan, C Song, L Chen Nature structural & molecular biology 25 (9), 850-858, 2018 | 158 | 2018 |
| AMP-activated protein kinase undergoes nucleotide-dependent conformational changes L Chen, J Wang, YY Zhang, SF Yan, D Neumann, U Schlattner, ZX Wang, ... Nature structural & molecular biology 19 (7), 716-718, 2012 | 137 | 2012 |
| X-ray structures of AMPA receptor–cone snail toxin complexes illuminate activation mechanism L Chen, KL Dürr, E Gouaux Science 345 (6200), 1021-1026, 2014 | 125 | 2014 |
| Structural insights into the mechanism of human soluble guanylate cyclase Y Kang, R Liu, JX Wu, L Chen Nature 574 (7777), 206-210, 2019 | 117 | 2019 |
| Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels JX Wu, D Ding, M Wang, Y Kang, X Zeng, L Chen Protein & cell 9 (6), 553-567, 2018 | 93 | 2018 |
| Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1 J Wang, J Jiang, J Wang, L Chen, SL Fan, JW Wu, X Wang, ZX Wang Cell research 24 (11), 1328-1341, 2014 | 80 | 2014 |
| The structural basis for the binding of repaglinide to the pancreatic KATP channel D Ding, M Wang, JX Wu, Y Kang, L Chen Cell reports 27 (6), 1848-1857. e4, 2019 | 72 | 2019 |
| Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP) L Wang, YT Liu, R Hao, L Chen, Z Chang, HR Wang, ZX Wang, JW Wu Journal of Biological Chemistry 286 (18), 15883-15894, 2011 | 70 | 2011 |
| Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter Y Niu, R Liu, C Guan, Y Zhang, Z Chen, S Hoerer, H Nar, L Chen Nature 601 (7892), 280-284, 2022 | 68 | 2022 |
| Structural basis for human TRPC5 channel inhibition by two distinct inhibitors K Song, M Wei, W Guo, L Quan, Y Kang, JX Wu, L Chen Elife 10, e63429, 2021 | 56 | 2021 |
| Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor C Guan, Y Niu, SC Chen, Y Kang, JX Wu, K Nishi, CCY Chang, TY Chang, ... Nature communications 11 (1), 2478, 2020 | 54 | 2020 |
| Molecular basis of Wnt activation via the DIX domain protein Ccd1 YT Liu, QJ Dan, J Wang, Y Feng, L Chen, J Liang, Q Li, SC Lin, ZX Wang, ... Journal of Biological Chemistry 286 (10), 8597-8608, 2011 | 49 | 2011 |
| Structures of human dual oxidase 1 complex in low-calcium and high-calcium states JX Wu, R Liu, K Song, L Chen Nature Communications 12 (1), 155, 2021 | 43 | 2021 |
| Structural insights into the architecture and allostery of full-length AMP-activated protein kinase L Zhu, L Chen, XM Zhou, YY Zhang, YJ Zhang, J Zhao, SR Ji, JW Wu, ... Structure 19 (4), 515-522, 2011 | 41 | 2011 |
| Activation mechanism of human soluble guanylate cyclase by stimulators and activators R Liu, Y Kang, L Chen Nature Communications 12 (1), 5492, 2021 | 32 | 2021 |
| Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites W Guo, Q Tang, M Wei, Y Kang, JX Wu, L Chen Neuron 110 (6), 1023-1035. e5, 2022 | 29 | 2022 |
