Christopher Hindley
Christopher Hindley
Associate Director, Insmed Innovation UK Ltd
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Cited by
Cited by
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
L Broutier, A Andersson-Rolf, CJ Hindley, SF Boj, H Clevers, BK Koo, ...
Nature Protocols 11 (9), 1724-1743, 2016
iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis
DC Schöndorf, M Aureli, FE McAllister, CJ Hindley, F Mayer, B Schmid, ...
Nature communications 5 (1), 1-17, 2014
Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis
F Ali, C Hindley, G McDowell, R Deibler, A Jones, M Kirschner, ...
Development 138 (19), 4267-4277, 2011
Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse
PA Coelho, L Bury, MN Shahbazi, K Liakath-Ali, PH Tate, S Wormald, ...
Open biology 5 (12), 150209, 2015
The cell cycle and pluripotency
C Hindley, A Philpott
Biochemical Journal 451 (2), 135-143, 2013
Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation
C Hindley, F Ali, G McDowell, K Cheng, A Jones, F Guillemot, A Philpott
Development 139 (10), 1718-1723, 2012
The Hippo pathway member YAP enhances human neural crest cell fate and migration
CJ Hindley, AL Condurat, V Menon, R Thomas, LM Azmitia, JA Davis, ...
Scientific reports 6 (1), 1-9, 2016
Ubiquitylation on canonical and non-canonical sites targets the transcription factor neurogenin for ubiquitin-mediated proteolysis
JMD Vosper, GS McDowell, CJ Hindley, CS Fiore-Heriche, R Kucerova, ...
Journal of Biological Chemistry 284 (23), 15458-15468, 2009
Co-ordination of cell cycle and differentiation in the developing nervous system
C Hindley, A Philpott
Biochemical Journal 444 (3), 375-382, 2012
Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids
N Georgakopoulos, N Prior, B Angres, G Mastrogiovanni, A Cagan, ...
BMC Developmental Biology 20 (1), 1-20, 2020
Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation
R Azzarelli, C Hurley, MK Sznurkowska, S Rulands, L Hardwick, I Gamper, ...
Developmental cell 41 (3), 274-286. e5, 2017
Organoids from adult liver and pancreas: Stem cell biology and biomedical utility
CJ Hindley, L Cordero-Espinoza, M Huch
Developmental Biology 420 (2), 251-261, 2016
Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool
N Prior, CJ Hindley, F Rost, E Meléndez, WWY Lau, B Göttgens, ...
Development 146 (12), 2019
Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool
N Prior, CJ Hindley, F Rost, E Meléndez, WWY Lau, B Göttgens, ...
Development 146 (12), 2019
Combined flow cytometric analysis of surface and intracellular antigens reveals surface molecule markers of human neuropoiesis
G Turaç, CJ Hindley, R Thomas, JA Davis, M Deleidi, T Gasser, E Karaöz, ...
PLoS One 8 (6), e68519, 2013
Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development
MK Sznurkowska, E Hannezo, R Azzarelli, S Rulands, S Nestorowa, ...
Developmental cell 46 (3), 360-375. e5, 2018
The plastic liver: differentiated cells, stem cells, every cell?
CJ Hindley, G Mastrogiovanni, M Huch
The Journal of clinical investigation 124 (12), 5099-5102, 2014
Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2
GS McDowell, CJ Hindley, G Lippens, I Landrieu, A Philpott
BMC biochemistry 15 (1), 1-14, 2014
Regulation of cell fate determination by Skp1-Cullin1-F-box (SCF) E3 ubiquitin ligases
CJ Hindley, GS McDowell, H Wise, A Philpott
International Journal of Developmental Biology 55 (3), 249-260, 2011
ASTX029, a Novel Dual-Mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK
JM Munck, V Berdini, L Bevan, JL Brothwood, J Castro, A Courtin, C East, ...
Molecular Cancer Therapeutics, 2021
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