Per-Johan Jakobsson
Per-Johan Jakobsson
Professor in translational medicine, Karolinska University
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Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
PJ Jakobsson, S Thorén, R Morgenstern, B Samuelsson
Proceedings of the National Academy of Sciences 96 (13), 7220-7225, 1999
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
U Harre, D Georgess, H Bang, A Bozec, R Axmann, E Ossipova, ...
The Journal of clinical investigation 122 (5), 1791-1802, 2012
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase
CE Trebino, JL Stock, CP Gibbons, BM Naiman, TS Wachtmann, ...
Proceedings of the National Academy of Sciences 100 (15), 9044-9049, 2003
Membrane prostaglandin E synthase-1: a novel therapeutic target
B Samuelsson, R Morgenstern, PJ Jakobsson
Pharmacological reviews 59 (3), 207-224, 2007
Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis
WL Smith, Y Urade, PJ Jakobsson
Chemical reviews 111 (10), 5821-5865, 2011
Common structural features of MAPEG—a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism
PJ Jakobsson, R Morgenstern, J Mancini, A Ford-Hutchinson, B Persson
Protein Science 8 (3), 689-692, 1999
Pathway across the blood–brain barrier
M Ek, D Engblom, S Saha, A Blomqvist, PJ Jakobsson, ...
Nature 410 (6827), 430-431, 2001
Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides
KR Kozak, BC Crews, JD Morrow, LH Wang, YH Ma, R Weinander, ...
Journal of Biological Chemistry 277 (47), 44877-44885, 2002
Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss
A Krishnamurthy, V Joshua, AH Hensvold, T Jin, M Sun, N Vivar, ...
Annals of the rheumatic diseases 75 (4), 721-729, 2016
Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells
DO Stichtenoth, S Thorén, H Bian, M Peters-Golden, PJ Jakobsson, ...
The Journal of Immunology 167 (1), 469-474, 2001
Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis
D Engblom, S Saha, L Engström, M Westman, LP Audoly, PJ Jakobsson, ...
Nature neuroscience 6 (11), 1137-1138, 2003
Coordinate up‐and down‐regulation of glutathione‐dependent prostaglandin E synthase and cyclooxygenase‐2 in A549 cells: inhibition by NS‐398 and leukotriene C4
S Thorén, PJ Jakobsson
European journal of biochemistry 267 (21), 6428-6434, 2000
Autoantibodies to citrullinated proteins may induce joint pain independent of inflammation
G Wigerblad, DB Bas, C Fernades-Cerqueira, A Krishnamurthy, ...
Annals of the rheumatic diseases 75 (4), 730-738, 2016
Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer
K Yoshimatsu, D Golijanin, PB Paty, RA Soslow, PJ Jakobsson, ...
Clinical Cancer Research 7 (12), 3971-3976, 2001
Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5 …
PJ Jakobsson, JA Mancini, AW Ford-Hutchinson
Journal of Biological Chemistry 271 (36), 22203-22210, 1996
Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer
K Yoshimatsu, NK Altorki, D Golijanin, F Zhang, PJ Jakobsson, ...
Clinical Cancer Research 7 (9), 2669-2674, 2001
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
H Zirath, A Frenzel, G Oliynyk, L Segerström, UK Westermark, K Larsson, ...
Proceedings of the National Academy of Sciences 110 (25), 10258-10263, 2013
Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) a widespread protein superfamily
PJ Jakobsson, R Morgenstern, J Mancini, A Ford-Hutchinson, B Persson
American journal of respiratory and critical care medicine 161 (supplement_1 …, 2000
Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis
M Brink, M Hansson, L Mathsson, PJ Jakobsson, R Holmdahl, ...
Arthritis & Rheumatism 65 (4), 899-910, 2013
Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination
S Thorén, R Weinander, S Saha, C Jegerschöld, PL Pettersson, ...
Journal of Biological Chemistry 278 (25), 22199-22209, 2003
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