Garrett M Frampton
Garrett M Frampton
Foundation Medicine Inc.
Verifierad e-postadress på foundationmedicine.com
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Histone H3K27ac separates active from poised enhancers and predicts developmental state
MP Creyghton, AW Cheng, GG Welstead, T Kooistra, BW Carey, ...
Proceedings of the National Academy of Sciences 107 (50), 21931-21936, 2010
27892010
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm …
JE Rosenberg, J Hoffman-Censits, T Powles, MS Van Der Heijden, ...
The Lancet 387 (10031), 1909-1920, 2016
22182016
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
A Marson, SS Levine, MF Cole, GM Frampton, T Brambrink, S Johnstone, ...
Cell 134 (3), 521-533, 2008
15892008
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing
GM Frampton, A Fichtenholtz, GA Otto, K Wang, SR Downing, J He, ...
Nature biotechnology 31 (11), 1023-1031, 2013
13402013
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
ZR Chalmers, CF Connelly, D Fabrizio, L Gay, SM Ali, R Ennis, A Schrock, ...
Genome medicine 9 (1), 34, 2017
10402017
Tumor mutational burden as an independent predictor of response to immunotherapy in diverse cancers
AM Goodman, S Kato, L Bazhenova, SP Patel, GM Frampton, V Miller, ...
Molecular cancer therapeutics 16 (11), 2598-2608, 2017
8612017
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
D Lipson, M Capelletti, R Yelensky, G Otto, A Parker, M Jarosz, JA Curran, ...
Nature medicine 18 (3), 382-384, 2012
8122012
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
A Marson, K Kretschmer, GM Frampton, ES Jacobsen, JK Polansky, ...
Nature 445 (7130), 931-935, 2007
8082007
Densely interconnected transcriptional circuits control cell states in human hematopoiesis
N Novershtern, A Subramanian, LN Lawton, RH Mak, WN Haining, ...
Cell 144 (2), 296-309, 2011
7722011
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation
WA Whyte, S Bilodeau, DA Orlando, HA Hoke, GM Frampton, CT Foster, ...
Nature 482 (7384), 221-225, 2012
4852012
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells
MG Guenther, GM Frampton, F Soldner, D Hockemeyer, M Mitalipova, ...
Cell stem cell 7 (2), 249-257, 2010
4642010
Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors
GM Frampton, SM Ali, M Rosenzweig, J Chmielecki, X Lu, TM Bauer, ...
Cancer discovery 5 (8), 850-859, 2015
4232015
Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor–positive breast cancer
R Jeselsohn, R Yelensky, G Buchwalter, G Frampton, F Meric-Bernstam, ...
Clinical cancer research 20 (7), 1757-1767, 2014
4122014
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
CJ Lengner, AA Gimelbrant, JA Erwin, AW Cheng, MG Guenther, ...
Cell 141 (5), 872-883, 2010
3902010
Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity
H Beltran, R Yelensky, GM Frampton, K Park, SR Downing, ...
European urology 63 (5), 920-926, 2013
3762013
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns
T Tchkonia, M Lenburg, T Thomou, N Giorgadze, G Frampton, ...
American Journal of Physiology-Endocrinology and Metabolism 292 (1), E298-E307, 2007
3562007
STK11/LKB1 mutations and PD-1 inhibitor resistance in KRAS-mutant lung adenocarcinoma
F Skoulidis, ME Goldberg, DM Greenawalt, MD Hellmann, MM Awad, ...
Cancer discovery 8 (7), 822-835, 2018
3492018
Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities
F Skoulidis, LA Byers, L Diao, VA Papadimitrakopoulou, P Tong, J Izzo, ...
Cancer discovery 5 (8), 860-877, 2015
3382015
SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state
S Bilodeau, MH Kagey, GM Frampton, PB Rahl, RA Young
Genes & development 23 (21), 2484-2489, 2009
2902009
Targeted next generation sequencing identifies markers of response to PD-1 blockade
DB Johnson, GM Frampton, MJ Rioth, E Yusko, Y Xu, X Guo, RC Ennis, ...
Cancer immunology research 4 (11), 959-967, 2016
2612016
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