Följ
Sarah Meehan
Sarah Meehan
Andra namnSarah Yorke-Smith
Erasmus Medical Centre
Verifierad e-postadress på erasmusmc.nl
Titel
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Role of intermolecular forces in defining material properties of protein nanofibrils
TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, ...
science 318 (5858), 1900-1903, 2007
8482007
Metastability of native proteins and the phenomenon of amyloid formation
AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, ...
Journal of the American Chemical Society 133 (36), 14160-14163, 2011
4962011
The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures
JJ Yerbury, S Poon, S Meehan, B Thompson, JR Kumita, CM Dobson, ...
The FASEB Journal 21 (10), 2312-2322, 2007
3602007
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide
P Narayan, A Orte, RW Clarke, B Bolognesi, S Hook, KA Ganzinger, ...
Nature structural & molecular biology 19 (1), 79-83, 2012
2982012
Iron promotes the toxicity of amyloid β peptide by impeding its ordered aggregation
B Liu, A Moloney, S Meehan, K Morris, SE Thomas, LC Serpell, R Hider, ...
Journal of Biological Chemistry 286 (6), 4248-4256, 2011
2542011
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass
TPJ Knowles, W Shu, GL Devlin, S Meehan, S Auer, CM Dobson, ...
Proceedings of the National Academy of Sciences 104 (24), 10016-10021, 2007
2352007
Amyloid Fibril Formation by Bovine Milk κ-Casein and Its Inhibition by the Molecular Chaperones αS- and β-Casein
DC Thorn, S Meehan, M Sunde, A Rekas, SL Gras, CE MacPhee, ...
Biochemistry 44 (51), 17027-17036, 2005
2272005
Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation
S Meehan, Y Berry, B Luisi, CM Dobson, JA Carver, CE MacPhee
Journal of Biological Chemistry 279 (5), 3413-3419, 2004
2182004
Small heat-shock proteins: important players in regulating cellular proteostasis
TM Treweek, S Meehan, H Ecroyd, JA Carver
Cellular and molecular life sciences 72, 429-451, 2015
2122015
Structure and properties of a complex of α-synuclein and a single-domain camelid antibody
EJ De Genst, T Guilliams, J Wellens, EM O'day, CA Waudby, S Meehan, ...
Journal of molecular biology 402 (2), 326-343, 2010
2042010
Mimicking phosphorylation of αB-crystallin affects its chaperone activity
H Ecroyd, S Meehan, J Horwitz, JA Aquilina, JLP Benesch, CV Robinson, ...
Biochemical journal 401 (1), 129-141, 2007
2002007
Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation
SL Shammas, CA Waudby, S Wang, AK Buell, TPJ Knowles, H Ecroyd, ...
Biophysical journal 101 (7), 1681-1689, 2011
1822011
The interaction of αB-crystallin with mature α-synuclein amyloid fibrils inhibits their elongation
CA Waudby, TPJ Knowles, GL Devlin, JN Skepper, H Ecroyd, JA Carver, ...
Biophysical journal 98 (5), 843-851, 2010
1702010
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
B Mannini, R Cascella, M Zampagni, M van Waarde-Verhagen, S Meehan, ...
Proceedings of the National Academy of Sciences 109 (31), 12479-12484, 2012
1682012
Hsp90 inhibits α-synuclein aggregation by interacting with soluble oligomers
S Daturpalli, CA Waudby, S Meehan, SE Jackson
Journal of molecular biology 425 (22), 4614-4628, 2013
1232013
Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human αA-, αB-and R120G αB-crystallins
S Meehan, TPJ Knowles, AJ Baldwin, JF Smith, AM Squires, P Clements, ...
Journal of molecular biology 372 (2), 470-484, 2007
1122007
α2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species
JJ Yerbury, JR Kumita, S Meehan, CM Dobson, MR Wilson
Journal of biological chemistry 284 (7), 4246-4254, 2009
1052009
Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells
P Narayan, KA Ganzinger, J McColl, L Weimann, S Meehan, S Qamar, ...
Journal of the American Chemical Society 135 (4), 1491-1498, 2013
942013
Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones
P Narayan, S Meehan, JA Carver, MR Wilson, CM Dobson, D Klenerman
Biochemistry 51 (46), 9270-9276, 2012
922012
The Aggregation and Neurotoxicity of TDP-43 and Its ALS-Associated 25 kDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila
JM Gregory, TP Barros, S Meehan, CM Dobson, LM Luheshi
PloS one 7 (2), e31899, 2012
782012
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Artiklar 1–20