Följ
Kieran F. Geoghegan
Kieran F. Geoghegan
Formerly Research Fellow, Pfizer Worldwide Research
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Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.
PG Mitchell, HA Magna, LM Reeves, LL Lopresti-Morrow, SA Yocum, ...
The Journal of clinical investigation 97 (3), 761-768, 1996
11891996
Identification, characterization, and crystal structure of the Omega class glutathione transferases
PG Board, M Coggan, G Chelvanayagam, S Easteal, LS Jermiin, ...
Journal of Biological Chemistry 275 (32), 24798-24806, 2000
9082000
Structural basis of latency in plasminogen activator inhibitor-1
J Mottonen, A Strand, J Symersky, RM Sweet, DE Danley, KF Geoghegan, ...
Nature 355 (6357), 270-273, 1992
6951992
Site-directed conjugation of nonpeptide groups to peptides and proteins via periodate oxidation of a 2-amino alcohol. Application to modification at N-terminal serine
KF Geoghegan, JG Stroh
Bioconjugate chemistry 3 (2), 138-146, 1992
6801992
X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes
R Lapatto, T Blundell, A Hemmings, J Overington, A Wilderspin, S Wood, ...
Nature 342 (6247), 299-302, 1989
6101989
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia
D Cunningham, DE Danley, KF Geoghegan, MC Griffor, JL Hawkins, ...
Nature structural & molecular biology 14 (5), 413-419, 2007
5582007
Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules
X Qiu, A Mistry, MJ Ammirati, BA Chrunyk, RW Clark, Y Cong, JS Culp, ...
Nature structural & molecular biology 14 (2), 106-113, 2007
3182007
Spontaneous α-N-6-Phosphogluconoylation of a “His Tag” inEscherichia coli: The Cause of Extra Mass of 258 or 178 Da in Fusion Proteins
KF Geoghegan, HBF Dixon, PJ Rosner, LR Hoth, AJ Lanzetti, ...
Analytical biochemistry 267 (1), 169-184, 1999
3051999
Kinetic analysis of estrogen receptor/ligand interactions
RL Rich, LR Hoth, KF Geoghegan, TA Brown, PK LeMotte, SP Simons, ...
Proceedings of the National Academy of Sciences 99 (13), 8562-8567, 2002
3012002
Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1औ Posttranslational Processing
RE Laliberte, DG Perregaux, LR Hoth, PJ Rosner, CK Jordan, KM Peese, ...
Journal of Biological Chemistry 278 (19), 16567-16578, 2003
2462003
Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties
KF Geoghegan
US Patent 5,362,852, 1994
1991994
IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin.
D Perregaux, J Barberia, AJ Lanzetti, KF Geoghegan, TJ Carty, CA Gabel
Journal of immunology (Baltimore, Md.: 1950) 149 (4), 1294-1303, 1992
1801992
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms
MF Calabrese, F Rajamohan, MS Harris, NL Caspers, R Magyar, ...
Structure 22 (8), 1161-1172, 2014
1792014
X-ray analyses of peptide–inhibitor complexes define the structural basis of specificity for human and mouse renins
V Dhanaraj, CG Dealwis, C Frazao, M Badasso, BL Sibanda, IJ Tickle, ...
Nature 357 (6378), 466-472, 1992
1741992
Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes
EC Hett, H Xu, KF Geoghegan, A Gopalsamy, RE Kyne Jr, CA Menard, ...
ACS Chemical Biology 10 (4), 1094-1098, 2015
1632015
Concentration-dependent modulation of amyloid-β in vivo and in vitro using the γ-secretase inhibitor, LY-450139
TA Lanz, MJ Karmilowicz, KM Wood, N Pozdnyakov, P Du, MA Piotrowski, ...
Journal of Pharmacology and Experimental Therapeutics 319 (2), 924-933, 2006
1572006
Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition
JB Telliez, ME Dowty, LU Wang, J Jussif, T Lin, L Li, E Moy, P Balbo, W Li, ...
ACS chemical biology 11 (12), 3442-3451, 2016
1482016
Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid …
JL Hawkins, MD Robbins, LC Warren, D Xia, SF Petras, JJ Valentine, ...
Journal of Pharmacology and Experimental Therapeutics 326 (3), 801-808, 2008
1462008
Prolonged delivery of peptides
Y Kim, WJ Lambert, H Qi, RA Gelfand, KF Geoghegan, DE Danley
US Patent 6,284,727, 2001
1432001
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
NG Lintner, KF McClure, D Petersen, AT Londregan, DW Piotrowski, ...
PLoS biology 15 (3), e2001882, 2017
1292017
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