Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection FS Heldt, SY Kupke, S Dorl, U Reichl, T Frensing Nature communications 6 (1), 8938, 2015 | 150 | 2015 |
Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells T Frensing, SY Kupke, M Bachmann, S Fritzsche, LE Gallo-Ramirez, ... Applied microbiology and biotechnology 100, 7181-7192, 2016 | 77 | 2016 |
A novel type of influenza A virus-derived defective interfering particle with nucleotide substitutions in its genome SY Kupke, D Riedel, T Frensing, P Zmora, U Reichl Journal of Virology 93 (4), 10.1128/jvi. 01786-18, 2019 | 42 | 2019 |
Multiscale modeling of influenza A virus replication in cell cultures predicts infection dynamics for highly different infection conditions D Rüdiger, SY Kupke, T Laske, P Zmora, U Reichl PLOS Computational Biology 15 (2), e1006819, 2019 | 35 | 2019 |
Cell culture–based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration system MD Hein, A Chawla, M Cattaneo, SY Kupke, Y Genzel, U Reichl Applied microbiology and biotechnology 105, 7251-7264, 2021 | 26 | 2021 |
OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potential MD Hein, H Kollmus, P Marichal-Gallardo, S Püttker, D Benndorf, ... Applied microbiology and biotechnology 105, 129-146, 2021 | 24 | 2021 |
Antiviral activity of influenza A virus defective interfering particles against SARS-CoV-2 replication in vitro through stimulation of innate immunity U Rand, SY Kupke, H Shkarlet, MD Hein, T Hirsch, P Marichal-Gallardo, ... Cells 10 (7), 1756, 2021 | 23 | 2021 |
Semi-continuous propagation of influenza A virus and its defective interfering particles: analyzing the dynamic competition to select candidates for antiviral therapy L Pelz, D Rüdiger, T Dogra, FG Alnaji, Y Genzel, CB Brooke, SY Kupke, ... Journal of Virology 95 (24), 10.1128/jvi. 01174-21, 2021 | 22 | 2021 |
Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles MD Hein, P Arora, P Marichal-Gallardo, M Winkler, Y Genzel, S Pöhlmann, ... BMC biology 19 (1), 91, 2021 | 22 | 2021 |
Single-cell analysis uncovers a vast diversity in intracellular viral defective interfering RNA content affecting the large cell-to-cell heterogeneity in influenza A virus … SY Kupke, LH Ly, ST Börno, A Ruff, B Timmermann, M Vingron, S Haas, ... Viruses 12 (1), 71, 2020 | 19 | 2020 |
Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culture D Rüdiger, L Pelz, MD Hein, SY Kupke, U Reichl PLoS Computational Biology 17 (9), e1009357, 2021 | 10 | 2021 |
Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection. Nat Commun. 2015; 6: 8938 FS Heldt, SY Kupke, S Dorl, U Reichl, T Frensing Epub 2015/11/21. https://doi. org/10.1038/ncomms9938 PMID: 26586423, 0 | 9 | |
Absolute quantification of viral proteins during single-round replication of MDCK suspension cells J Küchler, S Püttker, P Lahmann, Y Genzel, S Kupke, D Benndorf, ... Journal of Proteomics 259, 104544, 2022 | 6 | 2022 |
Broad-spectrum antiviral activity of Influenza A defective interfering particles against respiratory syncytial, Yellow Fever, and Zika Virus replication in vitro L Pelz, E Piagnani, P Marsall, N Wynserski, MD Hein, P Marichal-Gallardo, ... Viruses 15 (9), 1872, 2023 | 4 | 2023 |
Generation of “OP7 chimera” defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice T Dogra, L Pelz, JD Boehme, J Kuechler, O Kershaw, P Marichal-Gallardo, ... Scientific Reports 13 (1), 20936, 2023 | 2 | 2023 |
Production of retroviral vectors in continuous high cell density culture MD Hein, D Kazenmaier, Y van Heuvel, T Dogra, M Cattaneo, SY Kupke, ... Applied Microbiology and Biotechnology 107 (19), 5947-5961, 2023 | 2 | 2023 |
Antiviral activity of influenza A virus defective interfering particles against SARS-CoV-2 replication in vitro through stimulation of innate immunity. Cells. 2021; 10 (7): 1756 U Rand, SY Kupke, H Shkarlet, MD Hein, T Hirsch, P Marichal-Gallardo, ... s Note: MDPI stays neutral with regard to jurisdictional claims in published …, 2021 | 1 | 2021 |
Production of antiviral “OP7 chimera” defective interfering particles free of infectious virus L Pelz, T Dogra, P Marichal-Gallardo, MD Hein, G Hemissi, SY Kupke, ... Applied Microbiology and Biotechnology 108 (1), 1-15, 2024 | | 2024 |
Influenza virus defective interfering particles for use in the prophylactic or therapeutic treatment of coronaviridae infection S Kupke, U Reichl, MD Hein, D Bruder US Patent App. 18/546,690, 2024 | | 2024 |
Mathematical model calibrated to in vitro data predicts mechanisms of antiviral action of the influenza defective interfering particle “OP7” D Rüdiger, J Piasecka, J Küchler, C Pontes, T Laske, SY Kupke, U Reichl Iscience 27 (4), 2024 | | 2024 |