|Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B|
DAE Cross, DR Alessi, P Cohen, M Andjelkovich, BA Hemmings
Nature 378 (6559), 785-789, 1995
|Specificity and mechanism of action of some commonly used protein kinase inhibitors|
SP Davies, H Reddy, M Caivano, P Cohen
Biochemical Journal 351 (1), 95-105, 2000
|PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo|
DR Alessi, A Cuenda, P Cohen, DT Dudley, AR Saltiel
Journal of Biological Chemistry 270 (46), 27489-27494, 1995
|Mechanism of activation of protein kinase B by insulin and IGF‐1.|
DR Alessi, M Andjelkovic, B Caudwell, P Cron, N Morrice, P Cohen, ...
The EMBO journal 15 (23), 6541-6551, 1996
|Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα|
DR Alessi, SR James, CP Downes, AB Holmes, PRJ Gaffney, CB Reese, ...
Current biology 7 (4), 261-269, 1997
|The ground state of embryonic stem cell self-renewal|
QL Ying, J Wray, J Nichols, L Batlle-Morera, B Doble, J Woodgett, ...
Nature 453 (7194), 519-523, 2008
|The structure and regulation of protein phosphatases|
Annual review of biochemistry 58 (1), 453-508, 1989
|The selectivity of protein kinase inhibitors: a further update|
J Bain, L Plater, M Elliott, N Shpiro, CJ Hastie, H Mclauchlan, I Klevernic, ...
Biochemical Journal 408 (3), 297-315, 2007
|Protein kinases—the major drug targets of the twenty-first century?|
Nature reviews Drug discovery 1 (4), 309-315, 2002
|SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1|
A Cuenda, J Rouse, YN Doza, R Meier, P Cohen, TF Gallagher, ...
FEBS letters 364 (2), 229-233, 1995
|A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins|
J Rouse, P Cohen, S Trigon, M Morange, A Alonso-Llamazares, ...
Cell 78 (6), 1027-1037, 1994
|Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants|
C MacKintosh, KA Beattie, S Klumpp, P Cohen, GA Codd
FEBS letters 264 (2), 187-192, 1990
|GSK3 takes centre stage more than 20 years after its discovery|
S Frame, P Cohen
Biochemical Journal 359 (1), 1-16, 2001
|The renaissance of GSK3|
P Cohen, S Frame
Nature reviews Molecular cell biology 2 (10), 769-776, 2001
|The specificities of protein kinase inhibitors: an update|
J Bain, H McLauchlan, M Elliott, P Cohen
Biochemical Journal 371 (1), 199-204, 2003
|Okadaic acid: a new probe for the study of cellular regulation|
P Cohen, CFB Holmes, Y Tsukitani
Trends in biochemical sciences 15 (3), 98-102, 1990
|The role of protein phosphorylation in neural and hormonal control of cellular activity|
Nature 296 (5858), 613-620, 1982
|Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1|
JA Le Good, WH Ziegler, DB Parekh, DR Alessi, P Cohen, PJ Parker
Science 281 (5385), 2042-2045, 1998
|Role of translocation in the activation and function of protein kinase B|
M Andjelkovic, DR Alessi, R Meier, A Fernandez, NJC Lamb, M Frech, ...
Journal of Biological Chemistry 272 (50), 31515-31524, 1997
|The regulation of protein function by multisite phosphorylation–a 25 year update|
Trends in biochemical sciences 25 (12), 596-601, 2000