David C Wedge

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Ludmil B. AlexandrovAssociate Professor, University of California San DiegoVerified email at ucsd.edu
Peter CampbellWellcome Sanger InstituteVerified email at sanger.ac.uk
Inigo MartincorenaWellcome Sanger InstituteVerified email at sanger.ac.uk
Moritz GerstungDivision Head, German Cancer Research Centre DKFZVerified email at dkfz.de
Douglas KellUniversity of LiverpoolVerified email at liv.ac.uk
Niccolo BolliUniversity of MilanVerified email at unimi.it
Roy GoodacreDepartment of Biochemistry and Systems Biology, ISMIB, University of LiverpoolVerified email at liverpool.ac.uk
Jose M. C. TubioMolecular Medicine and Chronic diseases Centre (CIMUS), University of Santiago de CompostelaVerified email at usc.es
Warwick DunnDepartment of Biochemistry and Systems Biology, ISMIB, University of LiverpoolVerified email at liverpool.ac.uk
Rebecca FitzgeraldProfessor of Cancer Prevention, Cambridge UniversityVerified email at cam.ac.uk
Ole-Christian LingjærdeDept of Computer Science, University of OsloVerified email at ifi.uio.no
Jyoti NangaliaWellcome Sanger Institute, Cambridge Stem Cell Institute, Cambridge University NHS TrustVerified email at sanger.ac.uk
Mark PlattDepartment of ChemistryVerified email at lboro.ac.uk
Elli PapaemmanuilMemorial Sloan Kettering Computational Oncology ServiceVerified email at sanger.ac.uk
Adam ButlerWellcome Trust Sanger InstituteVerified email at sanger.ac.uk
FRANCESCO MAURAUniversity of MiamiVerified email at med.miami.edu
Stian KnappskogProfessor, University of BergenVerified email at med.uib.no
Charlie MassieGroup Leader, Early Detection Programme, CRUK Cambridge CentreVerified email at cam.ac.uk
Mia PetljakBroad Institute of MIT and HarvardVerified email at broadinstitute.org
Dan J WoodcockUniversity of OxfordVerified email at well.ox.ac.uk

David C Wedge

Professor of Cancer Genomics and Data Science, University of Manchester

Verified email at manchester.ac.uk - Homepage

Cancer Genomics Cancer Evolution Data Science Biostatistics Artificial Intelligence


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Signatures of mutational processes in human cancer LB Alexandrov, S Nik-Zainal, DC Wedge, SAJR Aparicio, S Behjati, ... Nature 500 (7463), 415-421, 2013	7774	2013
Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2 J Nangalia, CE Massie, EJ Baxter, FL Nice, G Gundem, DC Wedge, ... New England Journal of Medicine 369 (25), 2391-2405, 2013	1820	2013
The landscape of cancer genes and mutational processes in breast cancer PJ Stephens, PS Tarpey, H Davies, P Van Loo, C Greenman, DC Wedge, ... Nature 486 (7403), 400-404, 2012	1696	2012
Mutational processes molding the genomes of 21 breast cancers S Nik-Zainal, LB Alexandrov, DC Wedge, P Van Loo, CD Greenman, ... Cell 149 (5), 979-993, 2012	1686	2012
Landscape of somatic mutations in 560 breast cancer whole-genome sequences S Nik-Zainal, H Davies, J Staaf, M Ramakrishna, D Glodzik, X Zou, ... Nature 534 (7605), 47-54, 2016	1621	2016
Clinical and biological implications of driver mutations in myelodysplastic syndromes E Papaemmanuil, M Gerstung, L Malcovati, S Tauro, G Gundem, ... Blood, The Journal of the American Society of Hematology 122 (22), 3616-3627, 2013	1609	2013
The life history of 21 breast cancers S Nik-Zainal, P Van Loo, DC Wedge, LB Alexandrov, CD Greenman, ... Cell 149 (5), 994-1007, 2012	1343	2012
High burden and pervasive positive selection of somatic mutations in normal human skin I Martincorena, A Roshan, M Gerstung, P Ellis, P Van Loo, S McLaren, ... Science 348 (6237), 880-886, 2015	1273	2015
The evolutionary history of lethal metastatic prostate cancer G Gundem, P Van Loo, B Kremeyer, LB Alexandrov, J Tubio, ... Nature 520 (7547), 353-357, 2015	1132	2015
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution EC De Bruin, N McGranahan, R Mitter, M Salm, DC Wedge, L Yates, ... Science 346 (6206), 251-256, 2014	1028	2014
Deciphering signatures of mutational processes operative in human cancer LB Alexandrov, S Nik-Zainal, DC Wedge, PJ Campbell, MR Stratton Cell reports 3 (1), 246-259, 2013	957	2013
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing J Zhang, J Fujimoto, J Zhang, DC Wedge, X Song, J Zhang, S Seth, ... Science 346 (6206), 256-259, 2014	851	2014
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma N Bolli, H Avet-Loiseau, DC Wedge, P Van Loo, LB Alexandrov, ... Nature communications 5 (1), 1-13, 2014	790	2014
Clock-like mutational processes in human somatic cells LB Alexandrov, PH Jones, DC Wedge, JE Sale, PJ Campbell, ... Nature genetics 47 (12), 1402-1407, 2015	716	2015
Subclonal diversification of primary breast cancer revealed by multiregion sequencing LR Yates, M Gerstung, S Knappskog, C Desmedt, G Gundem, P Van Loo, ... Nature medicine 21 (7), 751-759, 2015	672	2015
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone S Behjati, PS Tarpey, N Presneau, S Scheipl, N Pillay, P Van Loo, ... Nature genetics 45 (12), 1479-1482, 2013	587	2013
Effect of mutation order on myeloproliferative neoplasms CA Ortmann, DG Kent, J Nangalia, Y Silber, DC Wedge, J Grinfeld, ... New England Journal of Medicine 372 (7), 601-612, 2015	479	2015
The evolutionary history of 2,658 cancers M Gerstung, C Jolly, I Leshchiner, SC Dentro, S Gonzalez, D Rosebrock, ... Nature 578 (7793), 122-128, 2020	472	2020
Genomic evolution of breast cancer metastasis and relapse LR Yates, S Knappskog, D Wedge, JHR Farmery, S Gonzalez, ... Cancer cell 32 (2), 169-184. e7, 2017	470	2017
Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue CS Cooper, R Eeles, DC Wedge, P Van Loo, G Gundem, LB Alexandrov, ... Nature genetics 47 (4), 367-372, 2015	396	2015

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