Laurent Hoffer
Laurent Hoffer
Cancer Research Centre of Marseille (CRCM)
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Cited by
Cited by
Integrated strategy for lead optimization based on fragment growing: the diversity-oriented-target-focused-synthesis approach
L Hoffer, YV Voitovich, B Raux, K Carrasco, C Muller, AY Fedorov, ...
Journal of medicinal chemistry 61 (13), 5719-5732, 2018
Fragment-based drug design: computational and experimental state of the art
L Hoffer, JP Renaud, D Horvath
Combinatorial chemistry & high throughput screening 14 (6), 500-520, 2011
S4MPLE–sampler for multiple protein–ligand entities: Simultaneous docking of several entities
L Hoffer, D Horvath
Journal of chemical information and modeling 53 (1), 88-102, 2013
In silico fragment-based drug discovery: setup and validation of a fragment-to-lead computational protocol using S4MPLE
L Hoffer, JP Renaud, D Horvath
Journal of chemical information and modeling 53 (4), 836-851, 2013
Chemistry‐driven hit‐to‐lead optimization guided by structure‐based approaches
L Hoffer, C Muller, P Roche, X Morelli
Molecular Informatics 37 (9-10), 1800059, 2018
S4MPLE—sampler for multiple protein-ligand entities: methodology and rigid-site docking benchmarking
L Hoffer, C Chira, G Marcou, A Varnek, D Horvath
Molecules 20 (5), 8997-9028, 2015
Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo
R Leblanc, R Kashyap, K Barral, AL Egea‐Jimenez, D Kovalskyy, ...
Journal of extracellular vesicles 10 (2), e12039, 2020
Fr-PPIChem: An academic compound library dedicated to protein–protein interactions
N Bosc, C Muller, L Hoffer, D Lagorce, S Bourg, C Derviaux, ME Gourdel, ...
ACS chemical biology 15 (6), 1566-1574, 2020
Synthesis and evaluation of the antibacterial activities of 13-substituted berberine derivatives
H Olleik, T Yacoub, L Hoffer, SM Gnansounou, K Benhaiem-Henry, ...
Antibiotics 9 (7), 381, 2020
In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor
J Ariey‐Bonnet, K Carrasco, M Le Grand, L Hoffer, S Betzi, M Feracci, ...
Molecular Oncology 14 (12), 3083-3099, 2020
Discovery of nanomolar DCAF1 small molecule ligands
ASM Li, S Kimani, B Wilson, M Noureldin, H González-Álvarez, A Mamai, ...
Journal of Medicinal Chemistry 66 (7), 5041-5060, 2023
Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors
J Hernandez, L Hoffer, B Coutard, G Quérat, P Roche, X Morelli, ...
European journal of medicinal chemistry 161, 323-333, 2019
CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy
L Hoffer, M Saez-Ayala, D Horvath, A Varnek, X Morelli, P Roche
Journal of Chemical Information and Modeling 59 (4), 1472-1485, 2019
Développement et validation du logiciel S4MPLE: application au docking moléculaire et à l'optimisation de fragments assistée par ordinateur dans le cadre du fragment-based drug …
L Hoffer
Université de Strasbourg, 2013
Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread
M Garcia, L Hoffer, R Leblanc, F Benmansour, M Feracci, C Derviaux, ...
European Journal of Medicinal Chemistry 223, 113601, 2021
From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia
M Saez-Ayala, L Hoffer, S Abel, K Ben Yaala, B Sicard, GP Andrieu, ...
Nature Communications 14 (1), 3079, 2023
Rational design of PDZ domain inhibitors: discovery of small organic compounds targeting PDZ domains
L Hoffer, P Roche, X Morelli
PDZ Mediated Interactions: Methods and Protocols, 277-289, 2021
Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer
L Ganier, S Betzi, C Derviaux, P Roche, C Dessaux, C Muller, L Hoffer, ...
ACS Chemical Biology 17 (5), 1061-1072, 2022
CRCM5484: A BET-BDII selective compound with differential anti-leukemic drug modulation
K Carrasco, C Montersino, C Derviaux, M Saez-Ayala, L Hoffer, ...
Journal of Medicinal Chemistry 65 (7), 5660-5674, 2022
Discovery of Conformationally Constrained ALK2 Inhibitors
H González-Álvarez, D Ensan, T Xin, JF Wong, CA Zepeda-Velázquez, ...
Journal of Medicinal Chemistry, 2024
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