Kathleen M. Giacomini
Kathleen M. Giacomini
Professor, UCSF
Verified email at - Homepage
Cited by
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Membrane transporters in drug development
Nature reviews Drug discovery 9 (3), 215-236, 2010
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
Y Shu, SA Sheardown, C Brown, RP Owen, S Zhang, RA Castro, ...
The Journal of clinical investigation 117 (5), 1422-1431, 2007
SLC transporters as therapeutic targets: emerging opportunities
L Lin, SW Yee, RB Kim, KM Giacomini
Nature reviews Drug discovery 14 (8), 543-560, 2015
Metformin pathways: pharmacokinetics and pharmacodynamics
L Gong, S Goswami, KM Giacomini, RB Altman, TE Klein
Pharmacogenetics and genomics 22 (11), 820-827, 2012
Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics
Y Shu, C Brown, RA Castro, RJ Shi, ET Lin, RP Owen, SA Sheardown, ...
Clinical pharmacology & therapeutics 83 (2), 273-280, 2008
Organic cation transporters are determinants of oxaliplatin cytotoxicity
S Zhang, KS Lovejoy, JE Shima, LL Lagpacan, Y Shu, A Lapuk, Y Chen, ...
Cancer research 66 (17), 8847-8857, 2006
The concentrative nucleoside transporter family, SLC28
JH Gray, RP Owen, KM Giacomini
Pflügers Archiv 447, 728-734, 2004
Cloning and functional expression of a human liver organic cation transporter
L Zhang, MJ Dresser, AT Gray, SC Yost, S Terashita, KM Giacomini
Molecular pharmacology 51 (6), 913-921, 1997
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene
DL Kroetz, C Pauli-Magnus, LM Hodges, CC Huang, M Kawamoto, ...
Pharmacogenetics and Genomics 13 (8), 481-494, 2003
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges
RA Wilke, DW Lin, DM Roden, PB Watkins, D Flockhart, I Zineh, ...
Nature reviews Drug discovery 6 (11), 904-916, 2007
Emerging transporters of clinical importance: an update from the International Transporter Consortium
KM Hillgren, D Keppler, AA Zur, KM Giacomini, B Stieger, CE Cass, ...
Clinical Pharmacology & Therapeutics 94 (1), 52-63, 2013
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects
LR Treviņo, N Shimasaki, W Yang, JC Panetta, C Cheng, D Pei, D Chan, ...
Journal of Clinical Oncology 27 (35), 5972, 2009
Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters
MJ Dresser, MK Leabman, KM Giacomini
Journal of pharmaceutical sciences 90 (4), 397-421, 2001
When good drugs go bad
KM Giacomini, RM Krauss, DM Roden, M Eichelbaum, MR Hayden, ...
Nature 446 (7139), 975-977, 2007
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1
Y Shu, MK Leabman, B Feng, LM Mangravite, CC Huang, D Stryke, ...
Proceedings of the National Academy of Sciences 100 (10), 5902-5907, 2003
Renal transporters in drug development
KM Morrissey, SL Stocker, MB Wittwer, L Xu, KM Giacomini
Annual review of pharmacology and toxicology 53, 503-529, 2013
Pharmacogenomics: challenges and opportunities
DM Roden, RB Altman, NL Benowitz, DA Flockhart, KM Giacomini, ...
Annals of internal medicine 145 (10), 749-757, 2006
The pharmacogenetics research network: from SNP discovery to clinical drug response
KM Giacomini, CM Brett, RB Altman, NL Benowitz, ME Dolan, ...
Clinical Pharmacology & Therapeutics 81 (3), 328-345, 2007
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition
LB Ramsey, GH Bruun, W Yang, LR Treviņo, S Vattathil, P Scheet, ...
Genome research 22 (1), 1-8, 2012
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin
Y Chen, S Li, C Brown, S Cheatham, RA Castro, MK Leabman, TJ Urban, ...
Pharmacogenetics and genomics 19 (7), 497-504, 2009
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