| AND-gate contrast agents for enhanced fluorescence-guided surgery JC Widen, M Tholen, JJ Yim, A Antaris, KM Casey, S Rogalla, A Klaassen, ... Nature biomedical engineering 5 (3), 264-277, 2021 | 80 | 2021 |
| The endolysosomal cysteine cathepsins L and K are involved in macrophage‐mediated clearance of Staphylococcus aureus and the concomitant cytokine induction S Müller, A Faulhaber, C Sieber, D Pfeifer, T Hochberg, M Gansz, ... The FASEB Journal 28 (1), 162-175, 2014 | 60 | 2014 |
| Optimization of a protease activated probe for optical surgical navigation JJ Yim, M Tholen, A Klaassen, J Sorger, M Bogyo Molecular Pharmaceutics 15 (3), 750-758, 2017 | 54 | 2017 |
| Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome S Tholen, ML Biniossek, M Gansz, A Gomez-Auli, F Bengsch, A Noel, ... Molecular & Cellular Proteomics 12 (3), 611-625, 2013 | 43 | 2013 |
| Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis S Tholen, ML Biniossek, M Gansz, TD Ahrens, M Schlimpert, ... Cellular and molecular life sciences 71, 899-916, 2014 | 39 | 2014 |
| The clinical drug ebselen attenuates inflammation and promotes microbiome recovery in mice after antibiotic treatment for CDI M Garland, AJ Hryckowian, M Tholen, KO Bender, WW Van Treuren, ... Cell Reports Medicine 1 (1), 2020 | 33 | 2020 |
| Stress-resistant translation of cathepsin L mRNA in breast cancer progression M Tholen, J Wolanski, B Stolze, M Chiabudini, M Gajda, P Bronsert, ... Journal of Biological Chemistry 290 (25), 15758-15769, 2015 | 28 | 2015 |
| Design of Optical‐Imaging Probes by Screening of Diverse Substrate Libraries Directly in Disease‐Tissue Extracts M Tholen, JJ Yim, K Groborz, E Yoo, BA Martin, NS van den Berg, M Drag, ... Angewandte Chemie International Edition 59 (43), 19143-19152, 2020 | 20 | 2020 |
| The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis TW Bilverstone, M Garland, RJ Cave, ML Kelly, M Tholen, DM Bouley, ... PLoS pathogens 16 (9), e1008852, 2020 | 20 | 2020 |
| Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo M Tholen, LE Hillebrand, S Tholen, O Sedelmeier, SJ Arnold, ... Nature Communications 5 (1), 4931, 2014 | 19 | 2014 |
| Formalin-fixed, paraffin-embedded tissues (FFPE) as a robust source for the profiling of native and protease-generated protein amino termini ZW Lai, J Weisser, L Nilse, F Costa, E Keller, M Tholen, JN Kizhakkedathu, ... Molecular & Cellular Proteomics 15 (6), 2203-2213, 2016 | 17 | 2016 |
| Short-wave infrared fluorescence chemical sensor for detection of otitis media JJ Yim, SP Singh, A Xia, R Kashfi-Sadabad, M Tholen, DM Huland, ... ACS sensors 5 (11), 3411-3419, 2020 | 15 | 2020 |
| Low‐level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus T Reinheckel, M Tholen FEBS Open bio 12 (4), 694-707, 2022 | 12 | 2022 |
| Chemical tools for selective activity profiling of endogenously expressed MMP-14 in multicellular models N Amara, M Tholen, M Bogyo ACS chemical biology 13 (9), 2645-2654, 2018 | 11 | 2018 |
| Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression FC Sigloch, M Tholen, A Gomez-Auli, ML Biniossek, T Reinheckel, ... Journal of Cancer 8 (19), 4065, 2017 | 10 | 2017 |
| Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis E Neuwirt, G Magnani, T Ćiković, S Wöhrle, L Fischer, A Kostina, ... Science Signaling 16 (768), eabh1083, 2023 | 9 | 2023 |
| Methods for analysis of near-infrared (NIR) quenched-fluorescent contrast agents in mouse models of cancer JC Widen, M Tholen, JJ Yim, M Bogyo Methods in enzymology 639, 141-166, 2020 | 9 | 2020 |
| Exploring systemic functions of lysosomal proteases: the perspective of genetically modified mouse models M Gansz, U Kern, C Peters, T Reinheckel Proteases: structure and function, 217-233, 2013 | 4 | 2013 |
| Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome E Neuwirt, G Magnani, T Ćiković, A Kostina, S Wöhrle, S Flemming, ... bioRxiv, 2022.02. 19.480941, 2022 | 2 | 2022 |
| Multivariate AND-gate substrate probes as enhanced contrast agents for fluorescence-guided surgery JC Widen, M Tholen, JJ Yim, A Antaris, KM Casey, S Rogalla, A Klaassen, ... bioRxiv, 695403, 2019 | 1 | 2019 |
