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David Shorthouse
David Shorthouse
Lecturer, UCL School of Pharmacy
Verifierad e-postadress på ucl.ac.uk
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Lipid clustering correlates with membrane curvature as revealed by molecular simulations of complex lipid bilayers
H Koldsø, D Shorthouse, J Hélie, MSP Sansom
PLoS computational biology 10 (10), e1003911, 2014
2262014
Tumor-induced stromal reprogramming drives lymph node transformation
A Riedel, D Shorthouse, L Haas, BA Hall, J Shields
Nature immunology 17 (9), 1118-1127, 2016
1592016
Nothing to sneeze at: a dynamic and integrative computational model of an influenza A virion
T Reddy, D Shorthouse, DL Parton, E Jefferys, PW Fowler, M Chavent, ...
Structure 23 (3), 584-597, 2015
1092015
Selection of oncogenic mutant clones in normal human skin varies with body site
JC Fowler, C King, C Bryant, MWJ Hall, R Sood, SH Ong, E Earp, ...
Cancer discovery 11 (2), 340-361, 2021
762021
Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity
FK Turrell, EM Kerr, M Gao, H Thorpe, GJ Doherty, J Cridge, ...
Genes & development 31 (13), 1339-1353, 2017
642017
Free energy landscape of lipid interactions with regulatory binding sites on the transmembrane domain of the EGF receptor
G Hedger, D Shorthouse, H Koldsø, MSP Sansom
The Journal of Physical Chemistry B 120 (33), 8154-8163, 2016
572016
The NALCN channel regulates metastasis and nonmalignant cell dissemination
EP Rahrmann, D Shorthouse, A Jassim, LP Hu, M Ortiz, B Mahler-Araujo, ...
Nature genetics 54 (12), 1827-1838, 2022
352022
Molecular simulations of glycolipids: Towards mammalian cell membrane models
D Shorthouse, G Hedger, H Koldsø, MSP Sansom
Biochimie 120, 105-109, 2016
352016
Exploring the role of stromal osmoregulation in cancer and disease using executable modelling
D Shorthouse, A Riedel, E Kerr, L Pedro, D Bihary, S Samarajiwa, ...
Nature Communications 9 (1), 3011, 2018
212018
Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance
M Lee, D Shorthouse, R Mahen, BA Hall, AR Venkitaraman
Nucleic Acids Research 49 (10), 5588-5604, 2021
202021
Tumor-derived lactic acid modulates activation and metabolic status of draining lymph node stroma
A Riedel, M Helal, L Pedro, JJ Swietlik, D Shorthouse, W Schmitz, L Haas, ...
Cancer immunology research 10 (4), 482-497, 2022
132022
SARS-CoV-2 variants are selecting for spike protein mutations that increase protein stability
D Shorthouse, BA Hall
Journal of Chemical Information and Modeling 61 (9), 4152-4155, 2021
132021
Computational saturation screen reveals the landscape of mutations in human fumarate hydratase
D Shorthouse, MWJ Hall, BA Hall
Journal of Chemical Information and Modeling 61 (4), 1970-1980, 2021
122021
Heterogeneity of the cancer cell line metabolic landscape
D Shorthouse, J Bradley, SE Critchlow, C Bendtsen, BA Hall
Molecular Systems Biology 18 (11), e11006, 2022
102022
A toolbox for discrete modelling of cell signalling dynamics
YZ Paterson, D Shorthouse, MW Pleijzier, N Piterman, C Bendtsen, ...
Integrative Biology 10 (6), 370-382, 2018
82018
HOXA9 has the hallmarks of a biological switch with implications in blood cancers
L Talarmain, MA Clarke, D Shorthouse, L Cabrera-Cosme, DG Kent, ...
Nature Communications 13 (1), 5829, 2022
72022
Hé lie, J., and Sansom, MSP (2014). Lipid clustering correlates with membrane curvature as revealed by molecular simulations of complex lipid bilayers
H Koldsø, D Shorthouse
PLoS Comput. Biol 10, e1003911, 0
6
Mutations observed in somatic evolution reveal underlying gene mechanisms
MWJ Hall, D Shorthouse, R Alcraft, PH Jones, BA Hall
Communications Biology 6 (1), 753, 2023
42023
Investigating structure function relationships in the NOTCH family through large-scale somatic DNA sequencing studies
MWJ Hall, D Shorthouse, PH Jones, BA Hall
bioRxiv, 2020.03. 31.018325, 2020
22020
The Role of Potassium Channels in the Pathogenesis of Gastrointestinal Cancers and Therapeutic Potential
D Shorthouse, JL Zhuang, EP Rahrmann, C Kosmidou, KW Rahrmann, ...
22020
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Artiklar 1–20