Sanjay R. Kharche
Sanjay R. Kharche
Research Scientist, Western University
Verifierad e-postadress på lhsc.on.ca - Startsida
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Pro‐arrhythmogenic effects of atrial fibrillation‐induced electrical remodelling: insights from the three‐dimensional virtual human atria
MA Colman, OV Aslanidi, S Kharche, MR Boyett, C Garratt, JC Hancox, ...
The Journal of physiology 591 (17), 4249-4272, 2013
Atrial proarrhythmia due to increased inward rectifier current (IK1) arising from KCNJ2 mutation–a simulation study
S Kharche, CJ Garratt, MR Boyett, S Inada, AV Holden, JC Hancox, ...
Progress in biophysics and molecular biology 98 (2-3), 186-197, 2008
Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation—A simulation study
H Zhang, S Kharche, AV Holden, JC Hancox
Progress in biophysics and molecular biology 96 (1-3), 112-131, 2008
A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases
S Kharche, J Yu, M Lei, H Zhang
American Journal of Physiology-Heart and circulatory physiology 301 (3 …, 2011
Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle
FC Howarth, NJ Chandler, S Kharche, JO Tellez, ID Greener, ...
Molecular and cellular biochemistry 319 (1), 105-114, 2008
Pro‐arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation – insights from modelling
S Kharche, I Adeniran, J Stott, P Law, MR Boyett, JC Hancox, H Zhang
The Journal of physiology 590 (18), 4501-4514, 2012
Steering and visualization: Enabling technologies for computational science
H Wright, RH Crompton, S Kharche, P Wenisch
Future Generation Computer Systems 26 (3), 506-513, 2010
Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains
C Moreno, A de la Cruz, A Oliveras, SR Kharche, M Guizy, N Comes, ...
Cardiovascular Research 105 (2), 223-232, 2015
Virtual tissue engineering of the human atrium: Modelling pharmacological actions on atrial arrhythmogenesis
OV Aslanidi, M Al-Owais, AP Benson, M Colman, CJ Garratt, SH Gilbert, ...
European journal of pharmaceutical sciences 46 (4), 209-221, 2012
Computational assessment of the functional role of sinoatrial node exit pathways in the human heart
SR Kharche, E Vigmond, IR Efimov, H Dobrzynski
PloS one 12 (9), e0183727, 2017
Optimization of catheter ablation of atrial fibrillation: insights gained from clinically-derived computer models
J Zhao, SR Kharche, BJ Hansen, TA Csepe, Y Wang, MK Stiles, ...
International journal of molecular sciences 16 (5), 10834-10854, 2015
BeatBox—HPC simulation environment for biophysically and anatomically realistic cardiac electrophysiology
M Antonioletti, VN Biktashev, A Jackson, SR Kharche, T Stary, ...
PLoS One 12 (5), e0172292, 2017
Simulation of clinical electrophysiology in 3D human atria: a high‐performance computing and high‐performance visualization application
S Kharche, G Seemann, L Margetts, J Leng, AV Holden, H Zhang
Concurrency and Computation: Practice and Experience 20 (11), 1317-1328, 2008
Effects of human atrial ionic remodelling by β-blocker therapy on mechanisms of atrial fibrillation: a computer simulation
SR Kharche, T Stary, MA Colman, IV Biktasheva, AJ Workman, AC Rankin, ...
Europace 16 (10), 1524-1533, 2014
A computer simulation study of anatomy induced drift of spiral waves in the human atrium
SR Kharche, IV Biktasheva, G Seemann, H Zhang, VN Biktashev
BioMed research international 2015, 2015
Mechanisms underlying adaptation of action potential duration by pacing rate in rat myocytes
L Sallé, S Kharche, H Zhang, F Brette
Progress in biophysics and molecular biology 96 (1-3), 305-320, 2008
Simulating the effects of atrial fibrillation induced electrical remodeling: a comprehensive simulation study
S Kharche, H Zhang
2008 30th Annual International Conference of the IEEE Engineering in …, 2008
Endogenous driving and synchronization in cardiac and uterine virtual tissues: bifurcations and local coupling
AP Benson, RH Clayton, AV Holden, S Kharche, WC Tong
Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2006
Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis
M Zi, TE Kimura, W Liu, J Jin, J Higham, S Kharche, G Hao, Y Shi, W Shen, ...
Journal of Biological Chemistry 286 (20), 17821-17830, 2011
Scroll waves in 3D virtual human atria: a computational study
S Kharche, G Seemann, J Leng, AV Holden, CJ Garratt, H Zhang
International Conference on Functional Imaging and Modeling of the Heart …, 2007
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