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Lucas Hoffman
Lucas Hoffman
Professor of Pediatrics and Microbiology, University of Washington
Verifierad e-postadress på u.washington.edu
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Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
EE Smith, DG Buckley, Z Wu, C Saenphimmachak, LR Hoffman, ...
Proceedings of the National Academy of Sciences 103 (22), 8487-8492, 2006
16042006
Aminoglycoside antibiotics induce bacterial biofilm formation
LR Hoffman, DA D'Argenio, MJ MacCoss, Z Zhang, RA Jones, SI Miller
Nature 436 (7054), 1171-1175, 2005
15902005
Virus-cell and cell-cell fusion
LD Hernandez, LR Hoffman, TG Wolfsberg, JM White
Annual review of cell and developmental biology 12 (1), 627-661, 1996
7791996
Failure to recover to baseline pulmonary function after cystic fibrosis pulmonary exacerbation
DB Sanders, RCL Bittner, M Rosenfeld, LR Hoffman, GJ Redding, ...
American journal of respiratory and critical care medicine 182 (5), 627-632, 2010
5642010
Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa
LR Hoffman, E Déziel, DA d'Argenio, F Lépine, J Emerson, S McNamara, ...
Proceedings of the National Academy of Sciences 103 (52), 19890-19895, 2006
5092006
Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients
DA D'Argenio, M Wu, LR Hoffman, HD Kulasekara, E Déziel, EE Smith, ...
Molecular microbiology 64 (2), 512-533, 2007
4172007
Restoring cystic fibrosis transmembrane conductance regulator function reduces airway bacteria and inflammation in people with cystic fibrosis and chronic lung infections
KB Hisert, SL Heltshe, C Pope, P Jorth, X Wu, RM Edwards, M Radey, ...
American journal of respiratory and critical care medicine 195 (12), 1617-1628, 2017
3522017
Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression
LR Hoffman, HD Kulasekara, J Emerson, LS Houston, JL Burns, ...
Journal of Cystic Fibrosis 8 (1), 66-70, 2009
3302009
Asymmetrical distribution of the second messenger c-di-GMP upon bacterial cell division
M Christen, HD Kulasekara, B Christen, BR Kulasekara, LR Hoffman, ...
Science 328 (5983), 1295-1297, 2010
3222010
LasR variant cystic fibrosis isolates reveal an adaptable quorum-sensing hierarchy in Pseudomonas aeruginosa
JB Feltner, DJ Wolter, CE Pope, MC Groleau, NE Smalley, EP Greenberg, ...
MBio 7 (5), 10.1128/mbio. 01513-16, 2016
2262016
Staphylococcus aureus Small-Colony Variants Are Independently Associated With Worse Lung Disease in Children With Cystic Fibrosis
DJ Wolter, JC Emerson, S McNamara, AM Buccat, X Qin, E Cochrane, ...
Clinical Infectious Diseases 57 (3), 384-391, 2013
1982013
Clinical effectiveness of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis: a clinical trial
DP Nichols, AC Paynter, SL Heltshe, SH Donaldson, CA Frederick, ...
American journal of respiratory and critical care medicine 205 (5), 529-539, 2022
1942022
Lung function and microbiota diversity in cystic fibrosis
L Cuthbertson, AW Walker, AE Oliver, GB Rogers, DW Rivett, ...
Microbiome 8, 1-13, 2020
1802020
The microbiota in bronchoalveolar lavage from young children with chronic lung disease includes taxa present in both the oropharynx and nasopharynx
RL Marsh, M Kaestli, AB Chang, MJ Binks, CE Pope, LR Hoffman, ...
Microbiome 4, 1-18, 2016
1782016
Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilience
FA Stressmann, GB Rogers, CJ Van Der Gast, P Marsh, LS Vermeer, ...
Thorax 67 (10), 867-873, 2012
1662012
Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?
FA Stressmann, GB Rogers, P Marsh, AK Lilley, TWV Daniels, MP Carroll, ...
Journal of Cystic Fibrosis 10 (5), 357-365, 2011
1582011
Return of FEV1 after pulmonary exacerbation in children with cystic fibrosis
DB Sanders, LR Hoffman, J Emerson, RL Gibson, M Rosenfeld, ...
Pediatric pulmonology 45 (2), 127-134, 2010
1502010
Nutrient Availability as a Mechanism for Selection of Antibiotic Tolerant Pseudomonas aeruginosa within the CF Airway
LR Hoffman, AR Richardson, LS Houston, HD Kulasekara, ...
PLoS pathogens 6 (1), e1000712, 2010
1502010
Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity
LR Hoffman, ID Kuntz, JM White
Journal of Virology 71 (11), 8808-8820, 1997
1431997
Pseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes
N Mayer-Hamblett, M Rosenfeld, RL Gibson, BW Ramsey, HD Kulasekara, ...
American journal of respiratory and critical care medicine 190 (3), 289-297, 2014
1342014
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