| Discovery of a potent and selective protein kinase CK2 inhibitor by high-throughput docking E Vangrevelinghe, K Zimmermann, J Schoepfer, R Portmann, D Fabbro, ... Journal of medicinal chemistry 46 (13), 2656-2662, 2003 | 289 | 2003 |
| A small-molecule dengue virus entry inhibitor QY Wang, SJ Patel, E Vangrevelinghe, HY Xu, R Rao, D Jaber, W Schul, ... Antimicrobial agents and chemotherapy 53 (5), 1823-1831, 2009 | 239 | 2009 |
| Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition O Weigert, AA Lane, L Bird, N Kopp, B Chapuy, D van Bodegom, ... Journal of experimental medicine 209 (2), 259-273, 2012 | 170 | 2012 |
| Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805 F Baffert, CH Régnier, A De Pover, C Pissot-Soldermann, GA Tavares, ... Molecular cancer therapeutics 9 (7), 1945-1955, 2010 | 144 | 2010 |
| Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent R Andraos, Z Qian, D Bonenfant, J Rubert, E Vangrevelinghe, C Scheufler, ... Cancer discovery 2 (6), 512-523, 2012 | 143 | 2012 |
| Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics J Schoepfer, H Fretz, B Chaudhuri, L Muller, E Seeber, L Meijer, O Lozach, ... Journal of medicinal chemistry 45 (9), 1741-1747, 2002 | 134 | 2002 |
| Activity of the type II JAK2 inhibitor CHZ868 in B cell acute lymphoblastic leukemia SC Wu, LS Li, N Kopp, J Montero, B Chapuy, A Yoda, AL Christie, H Liu, ... Cancer cell 28 (1), 29-41, 2015 | 114 | 2015 |
| Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family G Thoma, F Nuninger, R Falchetto, E Hermes, GA Tavares, ... Journal of medicinal chemistry 54 (1), 284-288, 2011 | 111 | 2011 |
| 3D-QSAR CoMFA study on imidazolinergic I2 ligands: a significant model through a combined exploration of structural diversity and methodology N Baurin, E Vangrevelinghe, L Morin-Allory, JY Mérour, P Renard, ... Journal of medicinal chemistry 43 (6), 1109-1122, 2000 | 66 | 2000 |
| Discovery and SAR of potent, orally available 2, 8-diaryl-quinoxalines as a new class of JAK2 inhibitors C Pissot-Soldermann, M Gerspacher, P Furet, C Gaul, P Holzer, ... Bioorganic & Medicinal Chemistry Letters 20 (8), 2609-2613, 2010 | 44 | 2010 |
| 2, 6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes MJ van Eis, JP Evenou, P Floersheim, C Gaul, SW Cowan-Jacob, ... Bioorganic & medicinal chemistry letters 21 (24), 7367-7372, 2011 | 43 | 2011 |
| Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension D Shaw, G Hollingworth, N Soldermann, E Sprague, W Schuler, ... Bioorganic & medicinal chemistry letters 24 (20), 4812-4817, 2014 | 41 | 2014 |
| New scoring functions for virtual screening from molecular dynamics simulations with a quantum-refined force-field (QRFF-MD). Application to cyclin-dependent kinase 2 P Ferrara, A Curioni, E Vangrevelinghe, T Meyer, T Mordasini, ... Journal of chemical information and modeling 46 (1), 254-263, 2006 | 41 | 2006 |
| An activating janus kinase-3 mutation is associated with cytotoxic T lymphocyte antigen-4-dependent immune dysregulation syndrome H Sic, M Speletas, V Cornacchione, M Seidl, M Beibel, B Linghu, F Yang, ... Frontiers in Immunology 8, 1824, 2017 | 31 | 2017 |
| Discovery and profiling of a selective and efficacious Syk inhibitor G Thoma, AB Smith, MJ van Eis, E Vangrevelinghe, J Blanz, R Aichholz, ... Journal of Medicinal Chemistry 58 (4), 1950-1963, 2015 | 29 | 2015 |
| Optimizing a weakly binding fragment into a potent RORγt inverse agonist with efficacy in an in vivo inflammation model DA Carcache, A Vulpetti, J Kallen, H Mattes, D Orain, R Stringer, ... Journal of medicinal chemistry 61 (15), 6724-6735, 2018 | 26 | 2018 |
| A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P3–P1 Pharmacophore N Ostermann, S Ruedisser, C Ehrhardt, W Breitenstein, A Marzinzik, ... Journal of medicinal chemistry 56 (6), 2196-2206, 2013 | 24 | 2013 |
| 2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors M Gerspacher, P Furet, C Pissot-Soldermann, C Gaul, P Holzer, ... Bioorganic & Medicinal Chemistry Letters 20 (5), 1724-1727, 2010 | 22 | 2010 |
| Computational approaches for fragment optimization E Vangrevelinghe, S Rudisser Current Computer-Aided Drug Design 3 (1), 69-83, 2007 | 22 | 2007 |
| Syk inhibitors with high potency in presence of blood G Thoma, J Blanz, P Bühlmayer, P Drückes, M Kittelmann, AB Smith, ... Bioorganic & Medicinal Chemistry Letters 24 (10), 2278-2282, 2014 | 21 | 2014 |
