| Quantifying the relationship between inhibition of VEGF receptor 2, drug‐induced blood pressure elevation and hypertension T Collins, K Gray, M Bista, M Skinner, C Hardy, H Wang, JT Mettetal, ... British Journal of Pharmacology 175 (4), 618-630, 2018 | 32 | 2018 |
| Modeling and simulation approaches for cardiovascular function and their role in safety assessment TA Collins, L Bergenholm, T Abdulla, JWT Yates, N Evans, MJ Chappell, ... CPT: pharmacometrics & systems pharmacology 4 (3), 175-188, 2015 | 31 | 2015 |
| Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors E Banks, M Grondine, D Bhavsar, E Barry, JG Kettle, VP Reddy, C Brown, ... Science Translational Medicine 12 (541), eaaz2481, 2020 | 24 | 2020 |
| Translational modeling of drug‐induced myelosuppression and effect of pretreatment myelosuppression for AZD5153, a selective BRD4 inhibitor TA Collins, MM Hattersley, JWT Yates, E Clark, M Mondal, JT Mettetal CPT: pharmacometrics & systems pharmacology 6 (6), 357-364, 2017 | 23 | 2017 |
| Understanding hematological toxicities using mathematical modeling C Fornari, LO O'Connor, JWT Yates, SYA Cheung, DI Jodrell, JT Mettetal, ... Clinical Pharmacology & Therapeutics 104 (4), 644-654, 2018 | 20 | 2018 |
| Quantifying drug‐induced bone marrow toxicity using a novel haematopoiesis systems pharmacology model C Fornari, L Oplustil O'Connor, C Pin, A Smith, JWT Yates, SYA Cheung, ... CPT: Pharmacometrics & Systems Pharmacology 8 (11), 858-868, 2019 | 15 | 2019 |
| Predicting QRS and PR interval prolongations in humans using nonclinical data L Bergenholm, J Parkinson, J Mettetal, ND Evans, MJ Chappell, T Collins British Journal of Pharmacology 174 (19), 3268-3283, 2017 | 12 | 2017 |
| Identity and visual literacy in South Africa J Brenner, D Andrew, T Collins Visual Communication 3 (2), 176-188, 2004 | 11 | 2004 |
| PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data L Bergenholm, T Collins, ND Evans, MJ Chappell, J Parkinson Journal of Pharmacological and Toxicological Methods 79, 34-44, 2016 | 7 | 2016 |
| Semi‐mechanistic modelling platform to assess cardiac contractility and haemodynamics in preclinical cardiovascular safety profiling of new molecular entities R Venkatasubramanian, TA Collins, LJ Lesko, JT Mettetal, MN Trame British Journal of Pharmacology 177 (15), 3568-3590, 2020 | 6 | 2020 |
| Current and future approaches to nonclinical cardiovascular safety assessment TA Collins, MG Rolf, A Pointon Drug Discovery Today 25 (7), 1129-1134, 2020 | 6 | 2020 |
| Systems modeling to quantify safety risks in early drug development: Using bifurcation analysis and agent-based modeling as examples C Pin, T Collins, M Gibbs, H Kimko The AAPS Journal 23 (4), 77, 2021 | 5 | 2021 |
| A tutorial on model informed approaches to cardiovascular safety with focus on cardiac repolarisation SYA Cheung, J Parkinson, U Wählby-Hamrén, CD Dota, ÅM Kragh, ... Journal of Pharmacokinetics and Pharmacodynamics 45, 365-381, 2018 | 5 | 2018 |
| A novel cardiovascular systems model to quantify drugs effects on the inter‐relationship between contractility and other hemodynamic variables Y Fu, H Taghvafard, MM Said, EI Rossman, TA Collins, ... CPT: Pharmacometrics & Systems Pharmacology 11 (5), 640-652, 2022 | 4 | 2022 |
| Safety and Preliminary Efficacy of Sabestomig (AZD7789), an Anti-PD-1 and Anti-TIM-3 Bispecific Antibody, in Patients with Relapsed or Refractory Classical Hodgkin Lymphoma … MG Mei, G Corazzelli, F Morschhauser, E Phillips, GP Collins, HJ Lee, ... Blood 142, 4433, 2023 | 1 | 2023 |
| 1313MO Safety and preliminary efficacy of AZD7789, a bispecific antibody targeting PD-1 and TIM-3, in patients (pts) with stage IIIB–IV non-small-cell lung cancer (NSCLC) with … B Besse, A Italiano, S Cousin, G Ruiter, E Felip, EC Alvarez, ... Annals of Oncology 34, S755, 2023 | 1 | 2023 |
| Importance of Stability Analysis When Using Nonlinear Semimechanistic Models to Describe Drug‐Induced Hematotoxicity C Fornari, C Pin, JWT Yates, JT Mettetal, TA Collins CPT: Pharmacometrics & Systems Pharmacology 9 (9), 498-508, 2020 | 1 | 2020 |
| Effects of Second-Generation Calcineurin Inhibitor, Voclosporin, on Calcineurin Isoform Activity and Nephrotoxicity in Comparison to Cyclosporine and Tacrolimus T Dang, XE Wang, A Staskiewicz, J Tong, R Saede, J Nish, T Collins, ... Journal of Pharmacology and Experimental Therapeutics 389 (S3), 2024 | | 2024 |
| Rationale and design of phase 1 FTIH study of FOXP3 antisense oligonucleotide AZD8701 in patients with selected advanced solid tumors. M Petruzzelli, S Postel-Vinay, E Garralda, JD Powderly, ML Johnson, ... Journal of Clinical Oncology 40 (16_suppl), TPS3166-TPS3166, 2022 | | 2022 |
| A phase 1 study to assess the effect of food on the gastrointestinal toxicity and pharmacokinetics of Selumetinib in adolescent with neurofibromatosis type 1-related plexiform … D Viskochil, A Burgess, S Oliver, S Collins, T Collins, N Wang, K So 2021 VIRTUAL NF CONFERENCE, JUNE 14 - 16, 2021, 2021 | | 2021 |
