F.J. Dekker
F.J. Dekker
Associate professor
Verified email at - Homepage
Cited by
Cited by
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis
G Siegel, G Obernosterer, R Fiore, M Oehmen, S Bicker, M Christensen, ...
Nature cell biology 11 (6), 705-716, 2009
Small-molecule inhibition of APT1 affects Ras localization and signaling
FJ Dekker, O Rocks, N Vartak, S Menninger, C Hedberg, R Balamurugan, ...
Nature chemical biology 6 (6), 449-456, 2010
Histone acetyl transferases as emerging drug targets
FJ Dekker, HJ Haisma
Drug discovery today 14 (19-20), 942-948, 2009
Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions
M Schmidt, FJ Dekker, H Maarsingh
Pharmacological reviews 65 (2), 670-709, 2013
Histone acetyltransferases: challenges in targeting bi-substrate enzymes
H Wapenaar, FJ Dekker
Clinical epigenetics 8 (1), 1-11, 2016
Inflammation, cancer and oxidative lipoxygenase activity are intimately linked
R Wisastra, FJ Dekker
Cancers 6 (3), 1500-1521, 2014
Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation
M Ghizzoni, HJ Haisma, H Maarsingh, FJ Dekker
Drug discovery today 16 (11-12), 504-511, 2011
Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases
FJ Dekker, T van den Bosch, NI Martin
Drug discovery today 19 (5), 654-660, 2014
Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras‐signaling modulators palmostatin B and M
M Rusch, TJ Zimmermann, M Bürger, FJ Dekker, K Görmer, G Triola, ...
Angewandte Chemie 123 (42), 10012-10016, 2011
Light‐controlled histone deacetylase (HDAC) inhibitors: towards photopharmacological chemotherapy
W Szymanski, ME Ourailidou, WA Velema, FJ Dekker, BL Feringa
Chemistry–A European Journal 21 (46), 16517-16524, 2015
6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site
M Ghizzoni, J Wu, T Gao, HJ Haisma, FJ Dekker, YG Zheng
European journal of medicinal chemistry 47, 337-344, 2012
HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 …
NGJ Leus, PE van der Wouden, T van den Bosch, WTR Hooghiemstra, ...
Biochemical pharmacology 108, 58-74, 2016
Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation
NGJ Leus, MRH Zwinderman, FJ Dekker
Current opinion in chemical biology 33, 160-168, 2016
Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative
M Ghizzoni, A Boltjes, C de Graaf, HJ Haisma, FJ Dekker
Bioorganic & medicinal chemistry 18 (16), 5826-5834, 2010
Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC)
R Balamurugan, FJ Dekker, H Waldmann
Molecular BioSystems 1 (1), 36-45, 2005
Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics
FJ Dekker, MA Koch, H Waldmann
Current opinion in chemical biology 9 (3), 232-239, 2005
Development of highly potent inhibitors of the Ras‐targeting human acyl protein thioesterases based on substrate similarity design
C Hedberg, FJ Dekker, M Rusch, S Renner, S Wetzel, N Vartak, ...
Angewandte Chemie International Edition 50 (42), 9832-9837, 2011
Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids
H Raj, W Szymański, J De Villiers, HJ Rozeboom, VP Veetil, CR Reis, ...
Nature Chemistry 4 (6), 478-484, 2012
Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras
J Xu, C Hedberg, FJ Dekker, Q Li, KM Haigis, E Hwang, H Waldmann, ...
Blood, The Journal of the American Society of Hematology 119 (4), 1032-1035, 2012
HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264. 7 macrophages and reduces cigarette smoke-induced airway inflammation in mice
NGJ Leus, T van den Bosch, PE van der Wouden, K Krist, ME Ourailidou, ...
Scientific reports 7 (1), 1-18, 2017
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