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Kurt Piepenbrink
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T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility
OY Borbulevych, KH Piepenbrink, BE Gloor, DR Scott, RF Sommese, ...
Immunity 31 (6), 885-896, 2009
2302009
Conformational changes and flexibility in T-cell receptor recognition of peptide–MHC complexes
KM Armstrong, KH Piepenbrink, BM Baker
Biochemical Journal 415 (2), 183-196, 2008
1732008
A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice
Z Yang, D Schmidt, W Liu, S Li, L Shi, J Sheng, K Chen, H Yu, ...
The Journal of infectious diseases 210 (6), 964-972, 2014
1072014
Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics
OY Borbulevych, KH Piepenbrink, BM Baker
The Journal of Immunology 186 (5), 2950-2958, 2011
972011
Disparate degrees of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism
DR Scott, OY Borbulevych, KH Piepenbrink, SA Corcelli, BM Baker
Journal of molecular biology 414 (3), 385-400, 2011
892011
Type IV pili promote early biofilm formation by Clostridium difficile
GA Maldarelli, KH Piepenbrink, AJ Scott, JA Freiberg, Y Song, ...
FEMS Pathogens and Disease 74 (6), ftw061, 2016
842016
Structural diversity in the type IV pili of multidrug-resistant Acinetobacter
KH Piepenbrink, E Lillehoj, CM Harding, JW Labonte, X Zuo, CA Rapp, ...
Journal of Biological Chemistry 291 (44), 22924-22935, 2016
772016
Motility and adhesion through type IV pili in Gram-positive bacteria
KH Piepenbrink, EJ Sundberg
Biochemical Society Transactions 44 (6), 1659-1666, 2016
762016
Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains
DH Aggen, AS Chervin, TM Schmitt, B Engels, JD Stone, SA Richman, ...
Gene therapy 19 (4), 365-374, 2012
762012
Structure-based design of hepatitis C virus vaccines that elicit neutralizing antibody responses to a conserved epitope
BG Pierce, EN Boucher, KH Piepenbrink, M Ejemel, CA Rapp, ...
Journal of virology 91 (20), 10.1128/jvi. 01032-17, 2017
642017
The basis for limited specificity and MHC restriction in a T cell receptor interface
KH Piepenbrink, SJ Blevins, DR Scott, BM Baker
Nature communications 4 (1), 1948, 2013
632013
Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors
DH Aggen, AS Chervin, FK Insaidoo, KH Piepenbrink, BM Baker, ...
Protein Engineering, Design & Selection 24 (4), 361-372, 2011
612011
Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain
W Piao, LW Ru, KH Piepenbrink, EJ Sundberg, SN Vogel, VY Toshchakov
Proceedings of the National Academy of Sciences 110 (47), 19036-19041, 2013
602013
Structural and evolutionary analyses show unique stabilization strategies in the type IV pili of Clostridium difficile
KH Piepenbrink, GA Maldarelli, CFM De La Peņa, TC Dingle, GL Mulvey, ...
Structure 23 (2), 385-396, 2015
572015
The structure of PilA from Acinetobacter baumannii AB5075 suggests a mechanism for functional specialization in Acinetobacter type IV pili
LA Ronish, E Lillehoj, JK Fields, EJ Sundberg, KH Piepenbrink
Journal of Biological Chemistry 294 (1), 218-230, 2019
562019
How an alloreactive T-cell receptor achieves peptide and MHC specificity
Y Wang, NK Singh, TT Spear, LM Hellman, KH Piepenbrink, ...
Proceedings of the National Academy of Sciences 114 (24), E4792-E4801, 2017
522017
DNA uptake by type IV filaments
KH Piepenbrink
Frontiers in Molecular Biosciences 6, 1, 2019
502019
Structure of Clostridium difficile PilJ exhibits unprecedented divergence from known type IV pilins
KH Piepenbrink, GA Maldarelli, CFM De La Peņa, GL Mulvey, GA Snyder, ...
Journal of Biological Chemistry 289 (7), 4334-4345, 2014
492014
Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner
KH Piepenbrink, OY Borbulevych, RF Sommese, J Clemens, ...
Biochemical Journal 423 (3), 353-361, 2009
422009
The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo
SW Hyun, A Liu, Z Liu, AS Cross, AC Verceles, S Magesh, Y Kommagalla, ...
Glycobiology 26 (8), 834-849, 2016
392016
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