|Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels|
SA Heusser, RJ Howard, CM Borghese, MA Cullins, T Broemstrup, ...
Molecular pharmacology 84 (5), 670-678, 2013
|Structural basis for a bimodal allosteric mechanism of general anesthetic modulation in pentameric ligand-gated ion channels|
Z Fourati, RJ Howard, SA Heusser, H Hu, RR Ruza, L Sauguet, E Lindahl, ...
Cell reports 23 (4), 993-1004, 2018
|Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity|
SA Heusser, M Lycksell, X Wang, SE McComas, RJ Howard, E Lindahl
Proceedings of the National Academy of Sciences 115 (42), 10672-10677, 2018
|Functional characterization of neurotransmitter activation and modulation in a nematode model ligand‐gated ion channel|
SA Heusser, Ö Yoluk, G Klement, EA Riederer, E Lindahl, RJ Howard
Journal of neurochemistry 138 (2), 243-253, 2016
|Physicochemical determinants of alcohol binding in a model ligand-gated ion channel|
TB Voigt, S Heusser, G Klement, I Pouya, AR Mola, TMD Ruel, JR Trudell, ...
Alcohol and Alcoholism 50, 2015
|Allosteric modulation of pentameric ligand-gated ion channels by general anesthetics|
Department of Biochemistry and Biophysics, Stockholm University, 2018