Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation B Drisaldi, RS Stewart, C Adles, LR Stewart, E Quaglio, E Biasini, L Fioriti, ... Journal of Biological Chemistry 278 (24), 21732-21743, 2003 | 284 | 2003 |
Essential role of coiled coils for aggregation and activity of Q/N-rich prions and PolyQ proteins F Fiumara, L Fioriti, ER Kandel, WA Hendrickson Cell 143 (7), 1121-1135, 2010 | 267 | 2010 |
The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3 L Fioriti, C Myers, YY Huang, X Li, JS Stephan, P Trifilieff, L Colnaghi, ... Neuron 86 (6), 1433-1448, 2015 | 227 | 2015 |
Neuralized1 activates CPEB3: a function for nonproteolytic ubiquitin in synaptic plasticity and memory storage E Pavlopoulos, P Trifilieff, V Chevaleyre, L Fioriti, S Zairis, A Pagano, ... Cell 147 (6), 1369-1383, 2011 | 206 | 2011 |
Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations L Fioriti, S Dossena, LR Stewart, RS Stewart, DA Harris, G Forloni, ... Journal of Biological Chemistry 280 (12), 11320-11328, 2005 | 138 | 2005 |
Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein A Orsi, L Fioriti, R Chiesa, R Sitia Journal of biological chemistry 281 (41), 30431-30438, 2006 | 137 | 2006 |
The CPEB3 protein is a functional prion that interacts with the actin cytoskeleton JS Stephan, L Fioriti, N Lamba, L Colnaghi, K Karl, IL Derkatch, ... Cell reports 11 (11), 1772-1785, 2015 | 136 | 2015 |
SUMOylation is an inhibitory constraint that regulates the prion-like aggregation and activity of CPEB3 B Drisaldi, L Colnaghi, L Fioriti, N Rao, C Myers, AM Snyder, DJ Metzger, ... Cell reports 11 (11), 1694-1702, 2015 | 129 | 2015 |
Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model S Dossena, L Imeri, M Mangieri, A Garofoli, L Ferrari, A Senatore, ... Neuron 60 (4), 598-609, 2008 | 124 | 2008 |
Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain S Nandi, D Chandramohan, L Fioriti, AM Melnick, JM Hébert, CE Mason, ... Proceedings of the National Academy of Sciences 113 (45), 12697-12702, 2016 | 94 | 2016 |
Proteasome inhibition and aggregation in Parkinson's disease: a comparative study in untransfected and transfected cells E Biasini, L Fioriti, I Ceglia, R Invernizzi, A Bertoli, R Chiesa, G Forloni Journal of neurochemistry 88 (3), 545-553, 2004 | 87 | 2004 |
CPEB3 inhibits translation of mRNA targets by localizing them to P bodies L Ford, E Ling, ER Kandel, L Fioriti Proceedings of the National Academy of Sciences 116 (36), 18078-18087, 2019 | 78 | 2019 |
The neurotoxicity of prion protein (PrP) peptide 106–126 is independent of the expression level of PrP and is not mediated by abnormal PrP species L Fioriti, E Quaglio, T Massignan, L Colombo, RS Stewart, M Salmona, ... Molecular and Cellular Neuroscience 28 (1), 165-176, 2005 | 75 | 2005 |
Liquid-liquid phase separation in physiology and pathophysiology of the nervous system Y Hayashi, LK Ford, L Fioriti, L McGurk, M Zhang Journal of Neuroscience 41 (5), 834-844, 2021 | 54 | 2021 |
Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor α (GDI)/Rab11 pathway T Massignan, E Biasini, E Lauranzano, P Veglianese, M Pignataro, ... Molecular & Cellular Proteomics 9 (4), 611-622, 2010 | 47 | 2010 |
Neurotoxic and gliotrophic activity of a synthetic peptide homologous to Gerstmann–Sträussler–Scheinker disease amyloid protein L Fioriti, N Angeretti, L Colombo, A De Luigi, A Colombo, C Manzoni, ... Journal of Neuroscience 27 (7), 1576-1583, 2007 | 45 | 2007 |
Analysis of the cerebellar proteome in a transgenic mouse model of inherited prion disease reveals preclinical alteration of calcineurin activity E Biasini, T Massignan, L Fioriti, V Rossi, S Dossena, M Salmona, ... Proteomics 6 (9), 2823-2834, 2006 | 25 | 2006 |
Super resolution microscopy of SUMO proteins in neurons L Colnaghi, L Russo, C Natale, E Restelli, A Cagnotto, M Salmona, ... Frontiers in Cellular Neuroscience 13, 486, 2019 | 22 | 2019 |
Cell type-specific neuroprotective activity of untranslocated prion protein E Restelli, L Fioriti, S Mantovani, S Airaghi, G Forloni, R Chiesa PLoS One 5 (10), e13725, 2010 | 22 | 2010 |
Coiled-coil motifs of RNA-binding proteins: dynamicity in RNA regulation LK Ford, L Fioriti Frontiers in cell and developmental biology 8, 607947, 2020 | 21 | 2020 |