Kristel Sleegers
Kristel Sleegers
VIB-Department of Molecular Genetics - University of Antwerp
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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
D Harold, R Abraham, P Hollingworth, R Sims, A Gerrish, ML Hamshere, ...
Nature genetics 41 (10), 1088-1093, 2009
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ...
Nature genetics 45 (12), 1452-1458, 2013
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ...
Nature genetics 43 (5), 429-435, 2011
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ...
Nature genetics 51 (3), 414-430, 2019
A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene …
I Gijselinck, T Van Langenhove, J van der Zee, K Sleegers, S Philtjens, ...
The Lancet Neurology 11 (1), 54-65, 2012
The genetic landscape of Alzheimer disease: clinical implications and perspectives
C Van Cauwenberghe, C Van Broeckhoven, K Sleegers
Genetics in Medicine 18 (5), 421-430, 2016
APOE and Alzheimer disease: a major gene with semi-dominant inheritance
E Genin, D Hannequin, D Wallon, K Sleegers, M Hiltunen, O Combarros, ...
Molecular psychiatry 16 (9), 903-907, 2011
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ...
Nature genetics 49 (9), 1373-1384, 2017
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
G Kleinberger, Y Yamanishi, M Suárez-Calvet, E Czirr, E Lohmann, ...
Science translational medicine 6 (243), 243ra86-243ra86, 2014
APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy
K Sleegers, N Brouwers, I Gijselinck, J Theuns, D Goossens, J Wauters, ...
Brain 129 (11), 2977-2983, 2006
Genetic insights in Alzheimer's disease
K Bettens, K Sleegers, C Van Broeckhoven
The Lancet Neurology 12 (1), 92-104, 2013
Molecular genetics of early-onset Alzheimer's disease revisited
R Cacace, K Sleegers, C Van Broeckhoven
Alzheimer's & dementia 12 (6), 733-748, 2016
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
J Chapuis, F Hansmannel, M Gistelinck, A Mounier, ...
Molecular psychiatry 18 (11), 1225-1234, 2013
Potent amyloidogenicity and pathogenicity of Aβ43
T Saito, T Suemoto, N Brouwers, K Sleegers, S Funamoto, N Mihira, ...
Nature neuroscience 14 (8), 1023-1032, 2011
Molecular genetics of Alzheimer's disease: an update
N Brouwers, K Sleegers, C Van Broeckhoven
Annals of medicine 40 (8), 562-583, 2008
ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study
MA Van Es, PW Van Vught, HM Blauw, L Franke, CG Saris, PM Andersen, ...
The Lancet Neurology 6 (10), 869-877, 2007
A Pan‐European Study of the C9orf72 Repeat Associated with FTLD: Geographic Prevalence, Genomic Instability, and Intermediate Repeats
J van der Zee, I Gijselinck, L Dillen, T Van Langenhove, J Theuns, ...
Human mutation 34 (2), 363-373, 2013
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
MA Van Es, PWJ Van Vught, HM Blauw, L Franke, CGJ Saris, ...
Nature genetics 40 (1), 29-31, 2008
sTREM 2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers
M Suárez‐Calvet, G Kleinberger, MÁ Araque Caballero, M Brendel, ...
EMBO molecular medicine 8 (5), 466-476, 2016
European Alzheimer’s Disease Initiative (EADI); Genetic and Environmental Risk in Alzheimer’s Disease; Alzheimer’s Disease Genetic Consortium; Cohorts for Heart and Aging …
JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ...
Nat Genet 45 (12), 1452-1458, 2013
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