Laura Greaves
Laura Greaves
Research Fellow, Newcastle University
Verifierad e-postadress på ncl.ac.uk - Startsida
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Mitochondrial DNA mutations in human colonic crypt stem cells
RW Taylor, MJ Barron, GM Borthwick, A Gospel, PF Chinnery, ...
The Journal of clinical investigation 112 (9), 1351-1360, 2003
5502003
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
D Jurk, C Wilson, JF Passos, F Oakley, C Correia-Melo, L Greaves, ...
Nature communications 5, 4172, 2014
4632014
Mitochondria are required for pro‐ageing features of the senescent phenotype
C Correia‐Melo, FDM Marques, R Anderson, G Hewitt, R Hewitt, J Cole, ...
The EMBO journal 35 (7), 724-742, 2016
2962016
Mitochondrial DNA and disease
LC Greaves, AK Reeve, RW Taylor, DM Turnbull
The Journal of pathology 226 (2), 274-286, 2012
2932012
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission
LC Greaves, SL Preston, PJ Tadrous, RW Taylor, MJ Barron, D Oukrif, ...
Proceedings of the National Academy of Sciences 103 (3), 714-719, 2006
2842006
Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells
SAC McDonald, LC Greaves, L Gutierrez–Gonzalez, M Rodriguez–Justo, ...
Gastroenterology 134 (2), 500-510, 2008
2342008
Locating the stem cell niche and tracing hepatocyte lineages in human liver
TG Fellous, S Islam, PJ Tadrous, G Elia, HM Kocher, S Bhattacharya, ...
Hepatology 49 (5), 1655-1663, 2009
1662009
Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies
SC Wilkinson, WJM Maas, JB Nielsen, LC Greaves, JJM van de Sandt, ...
International archives of occupational and environmental health 79 (5), 405-413, 2006
1072006
The ageing mitochondrial genome
KJ Krishnan, LC Greaves, AK Reeve, D Turnbull
Nucleic acids research 35 (22), 7399-7405, 2007
1042007
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
R Anderson, A Lagnado, D Maggiorani, A Walaszczyk, E Dookun, ...
The EMBO journal 38 (5), e100492, 2019
962019
Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing
LC Greaves, M Nooteboom, JL Elson, HAL Tuppen, GA Taylor, ...
PLoS Genet 10 (9), e1004620, 2014
922014
Mitochondrial DNA mutations and aging
KJ Krishnan, LC Greaves, AK Reeve, DM Turnbull
Annals of the New York Academy of Sciences 1100 (1), 227-240, 2007
782007
A methodological approach to tracing cell lineage in human epithelial tissues
TG Fellous, SAC McDonald, J Burkert, A Humphries, S Islam, ...
Stem Cells 27 (6), 1410-1420, 2009
722009
In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells
JK Blackwood, SC Williamson, LC Greaves, L Wilson, AC Rigas, ...
The Journal of pathology 225 (2), 181-188, 2011
662011
A phenotype-driven approach to generate mouse models with pathogenic mtDNA mutations causing mitochondrial disease
JHK Kauppila, HL Baines, A Bratic, ML Simard, C Freyer, A Mourier, ...
Cell reports 16 (11), 2980-2990, 2016
612016
Mitochondrial DNA defects and selective extraocular muscle involvement in CPEO
LC Greaves, P Yu-Wai-Man, EL Blakely, KJ Krishnan, NE Beadle, J Kerin, ...
Investigative ophthalmology & visual science 51 (7), 3340-3346, 2010
602010
Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point …
LC Greaves, JL Elson, M Nooteboom, JP Grady, GA Taylor, RW Taylor, ...
PLoS Genet 8 (11), e1003082, 2012
592012
Quantification of mitochondrial DNA mutation load
LC Greaves, NE Beadle, GA Taylor, D Commane, JC Mathers, K Khrapko, ...
Aging cell 8 (5), 566-572, 2009
592009
Age‐associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts
M Nooteboom, R Johnson, RW Taylor, NA Wright, RN Lightowlers, ...
Aging cell 9 (1), 96-99, 2010
582010
Mitochondrial DNA mutations and ageing
LC Greaves, DM Turnbull
Biochimica et Biophysica Acta (BBA)-General Subjects 1790 (10), 1015-1020, 2009
572009
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Artiklar 1–20