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Nigel J Gooderham
Nigel J Gooderham
Verifierad e-postadress på imperial.ac.uk
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CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans
AR Boobis, AM Lynch, S Murray, R de la Torre, A Solans, M Farré, ...
Cancer research 54 (1), 89-94, 1994
3221994
Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and …
C Sachse, U Bhambra, G Smith, TJ Lightfoot, JH Barrett, J Scollay, ...
British journal of clinical pharmacology 55 (1), 68-76, 2003
2582003
Metabolic surgery and cancer: protective effects of bariatric procedures
H Ashrafian, K Ahmed, SP Rowland, VM Patel, NJ Gooderham, E Holmes, ...
Cancer 117 (9), 1788-1799, 2011
1752011
Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer
C Maihöfner, MP Charalambous, U Bhambra, T Lightfoot, G Geisslinger, ...
Carcinogenesis 24 (4), 665-671, 2003
171*2003
Early events in the mammalian response to DNA double-strand breaks
LC Riches, AM Lynch, NJ Gooderham
Mutagenesis 23 (5), 331-339, 2008
1442008
Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) in humans
DG Walters, PJ Young, C Agus, MG Knize, AR Boobis, NJ Gooderham, ...
Carcinogenesis 25 (9), 1659-1669, 2004
1392004
Intra-and interindividual variability in systemic exposure in humans to 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine …
AM Lynch, MG Knize, AR Boobis, NJ Gooderham, DS Davies, S Murray
Cancer Research 52 (22), 6216-6223, 1992
1351992
Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man
S Murray, BG Lake, S Gray, AJ Edwards, C Springall, EA Bowey, ...
Carcinogenesis 22 (9), 1413-1420, 2001
1332001
Quantification of the carcinogens 2-amino-3, 8-dimethyl-and 2-amino-3, 4, 8-trimethylimidazo [4, 5-f] quinoxaline and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine in food …
S Murray, AM Lynch, MG Knize, NJ Gooderham
Journal of Chromatography B: Biomedical Sciences and Applications 616 (2 …, 1993
1311993
Investigation of interaction between N -acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer
JH Barrett, G Smith, R Waxman, N Gooderham, T Lightfoot, RC Garner, ...
Carcinogenesis 24 (2), 275-282, 2003
1222003
Detection and measurement of MeIQx in human urine after ingestion of a cooked meat meal
S Murray, NJ Gooderham, AR Boobis, DS Davies
Carcinogenesis 10 (4), 763-765, 1989
1201989
Identification of human urinary biomarkers of cruciferous vegetable consumption by metabonomic profiling
WMB Edmands, OP Beckonert, C Stella, A Campbell, BG Lake, JC Lindon, ...
Journal of proteome research 10 (10), 4513-4521, 2011
1192011
Nucleosomes bind to cell surface proteoglycans
K Watson, NJ Gooderham, DS Davies, RJ Edwards
Journal of Biological Chemistry 274 (31), 21707-21713, 1999
1141999
Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I …
D Kirkland, E Zeiger, F Madia, N Gooderham, P Kasper, A Lynch, T Morita, ...
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 775, 55-68, 2014
1112014
Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles
MBH Abdul Rahim, J Chilloux, L Martinez-Gili, AL Neves, A Myridakis, ...
Acta diabetologica 56, 493-500, 2019
1102019
Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-κB and IκB kinase-α in human colorectal cancer epithelial cells
MP Charalambous, C Maihöfner, U Bhambra, T Lightfoot, NJ Gooderham
British journal of cancer 88 (10), 1598-1604, 2003
1092003
The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity
SN Lauber, S Ali, NJ Gooderham
Carcinogenesis 25 (12), 2509-2517, 2004
1082004
Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phnylimidazo (4, 5-b) pyridine (PhIP) by human liver microsomes
K Zhao, S Murray, DS Davies, AR Boobis, NJ Gooderham
Carcinogenesis 15 (6), 1285-1288, 1994
1061994
Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3
SAA Patel, U Bhambra, MP Charalambous, RM David, RJ Edwards, ...
British journal of cancer 111 (12), 2287-2296, 2014
1042014
Measurement of MeIQx and DiMeIQx in fried beef by capillary column gas chromatography electron capture negative ion chemical ionisation mass spectrometry
S Murray, NJ Gooderham, AR Boobis, DS Davies
Carcinogenesis 9 (2), 321-325, 1988
1041988
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Artiklar 1–20